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Preparation method of nanogold-containing antibacterial agent

A technology of nano gold and antibacterial agent, applied in the field of medicine and health, can solve the problems of complex method, unsuitable antibacterial agent, strong toxicity of sodium borohydride, etc., and achieve the effect of simple process

Active Publication Date: 2018-01-19
重庆和其美科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, sodium borohydride is mostly used as a reducing agent to prepare nano gold. The method is complicated, the reaction conditions are not easy to control, and sodium borohydride itself has strong toxicity, so it is not suitable as an antibacterial agent for human body.

Method used

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  • Preparation method of nanogold-containing antibacterial agent
  • Preparation method of nanogold-containing antibacterial agent
  • Preparation method of nanogold-containing antibacterial agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A. Centrifuge 10mL egg white at 3000rpm for 10min, take the supernatant, and obtain reactant A;

[0028] B. Under the temperature condition of 20°C, add distilled water to dilute the reactant A obtained in step A to a mass fraction of 1%, and adjust the pH to 9 with a mass concentration of 0.4% sodium hydroxide solution, and mix well to obtain a mixed solution ;

[0029] C, under the temperature condition of 80 DEG C, the mass concentration is that 0.1% chloroauric acid solution is added to the mixed solution obtained in step B, after reacting for 20min, obtain the solution containing nano-gold, wherein the chloroauric acid solution is mixed with the solution obtained in step B The volume ratio of liquid is 1:20;

[0030] D, under the temperature condition of 80 ℃, mass fraction is that 0.1% methimazole solution is added in the containing nano-gold solution obtained in step C, after stirring and mixing, react 20min to obtain containing nano-gold antibacterial agent, in...

Embodiment 2

[0032] A. Centrifuge 5mL egg white at 4000rpm for 12min, take the supernatant, and obtain reactant A;

[0033] B. Under the temperature condition of 25°C, add distilled water to dilute the reactant A obtained in step A to a mass fraction of 3%, and adjust the pH to 10 with a mass concentration of 0.7% sodium hydroxide solution, and mix well to obtain a mixed solution ;

[0034] C, under the temperature condition of 90 DEG C, the mass concentration is that 0.5% chloroauric acid solution is added to the mixed solution obtained in step B, after reacting for 25min, obtain the mixed solution containing nano-gold, the chloroauric acid solution and the mixed solution obtained in step B The volume ratio is 1:30;

[0035] D, under the temperature condition of 90 DEG C, massfraction is that 0.5% methimazole solution is added in the containing nano-gold solution obtained in step C, after stirring and mixing, react 25min to obtain containing nano-gold antibacterial agent, in step C The ...

Embodiment 3

[0037] A. Centrifuge 20mL egg white at 5000rpm for 15min, take the supernatant, and obtain reactant A;

[0038] B. At a temperature of 30°C, add distilled water to dilute the reactant A obtained in step A to a mass fraction of 5%, and adjust the pH to 11 with a mass concentration of 1% sodium hydroxide solution, and mix well to obtain a mixed solution ;

[0039] C, under the temperature condition of 100 DEG C, mass concentration is that 1% chloroauric acid solution is added to the mixed solution obtained in step B, after reacting for 30min, obtain the mixed solution containing nano-gold, the chloroauric acid solution and the mixed solution obtained in step B The volume ratio is 1:50;

[0040] D, under the temperature condition of 100 DEG C, mass fraction is that 1% methimazole solution is added in the containing nano-gold solution obtained in step C, after stirring and mixing, react 30min to obtain containing nano-gold antibacterial agent, in step C The volume ratio of chlor...

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Abstract

The invention belongs to the technical field of medicine and health and relates to a preparation method of a nanogold-containing antibacterial agent. The preparation method comprises the following steps that A, egg white is centrifuged, liquid supernatant is taken, and a reactant A is obtained; B, under the temperature condition of 20-30 DEG C, distilled water is added in the reactant A obtained in the step A to dilute till the mass fraction is 1-5%, a sodium hydroxide solution is used for adjusting the pH to be 9-11, uniform mixing is conducted, and a mixed solution is obtained; C, under thetemperature condition of 80-100 DEG C, a chloroauric acid solution is added in the mixed solution obtained in the step B to react for 20-30 min, and then a nanogold-containing solution is obtained; and D, under the temperature condition of 80-100 DEG C, a methimazole solution is added in the nanogold-containing solution obtained in the step C, stirring and mixing are conducted, and after reaction,the nanogold-containing antibacterial agent is obtained. The nanogold-containing antibacterial agent has the excellent antibacterial property and biocompatibility, the safety and reliability are achieved, and the preparation method of the nanogold-containing antibacterial agent is simple.

Description

technical field [0001] The invention belongs to the technical field of medicine and hygiene, and in particular relates to a preparation method of an antibacterial agent containing nano-gold. Background technique [0002] With the widespread use of antibacterial drugs, the treatment of infectious diseases has faced new challenges, and bacteria have developed resistance to antibiotics. Moreover, with the continued use of antibiotics, the problem of bacterial resistance will continue to increase. On the one hand, the drug resistance of bacteria will cause all kinds of antibiotics to lose their effect, and the growth and reproduction of bacteria will become more and more difficult to control; on the other hand, it will seriously endanger human health and even threaten human survival. [0003] In 2014, China CHINET monitored the susceptibility and drug resistance of clinically isolated bacteria to commonly used antibacterial drugs in major domestic areas, showing that bacterial ...

Claims

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Application Information

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IPC IPC(8): B22F9/24B22F1/00A61K33/24A61P17/02A61P17/00A61P31/10A61P31/04A61P31/02B82Y30/00B82Y40/00
Inventor 蓝广芊卢必涛陆飞
Owner 重庆和其美科技有限公司
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