Methimazole detection method

A technology for the detection of methimazole and its detection method, which is applied in the field of detection of methimazole, can solve the problems of high cost, complicated operation, and restrictions on the wide use of the detection field, and achieve the effect of simple operation and low cost
CN107525791BActive Publication Date: 2020-04-03NANKAI UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
NANKAI UNIV
Publication Date
2020-04-03

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Abstract

The invention provides a methimazole detection method, which comprises the following steps of mixing methimazole with a first AuNPs solution to obtain a mixed solution; irradiating a first mixed solution formed by mixing the mixed solution with a first fluorescent N / S-CQDs solution with ultraviolet light to obtain a fluorescence spectrogram of the first mixed solution; irradiating a second mixed solution formed by mixing a second AuNPs solution and a second fluorescent N / S-CQDs solution with ultraviolet light to obtain a fluorescence spectrogram of the second mixed solution; obtaining the content of the methimazole according to the fluorescence spectrogram of the first mixed solution and the fluorescence spectrogram of the second mixed solution. The methimazole detection method provided by the invention uses the fluorescent N / S-CQDs as energy donors and AuNPs as energy receptors to construct a complex fluorescent probe, and the methimazole is detected by using the complex fluorescent probe. Compared with high performance liquid chromatography, flow injection spectrophotometry and the like, the cost is low, and the operation is easy.
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Description

technical field

[0001] The invention relates to the technical field of biological detection, in particular to a detection method of methimazole. Background technique

[0002] Methimazole is an anti-thyroid drug, which can reduce the synthesis of thyroid hormones and alleviate immune disorders, but overdose of methimazole can cause a series of diseases such as neutropenia and impaired visceral function; methimazole It is often illegally used for animal feeding to increase production and weight, increase meat production, and seek economic benefits. Through this method, methimazole will enter the food chain and pose a major hazard to human life and health. Therefore, the detection of methimazole is particularly important.

[0003] At present, the methods for determining the content of methimazole include several common methods such as spectrophotometry, supercritical fluid chromatography, chemiluminescence, and high performance gas-liquid chromatography. However, these method...

Claims

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