27 results about "Hyperthyroids" patented technology

Provided are a fully human TSH receptor (TSHR) blocking monoclonal antibody for treating hyperthyroidism, and a preparation method therefor and a use thereof. The method comprises the following steps: using flow cytometry to sort plasma cells and memory single B cells specifically recognizing a TSHR in the peripheral blood of patients having high titers of TSHR blocking antibody (TSH-stimulating blocking antibody, TBAb), performing in vitro cloning of antibody light and heavy chains and performing recombinant expression, and using hTSHR-CHO cells for antibody property screening and validation, to obtain a blocking monoclonal antibody specifically targeting human TSHR. The fully human TSHR blocking monoclonal antibody can specifically bind to the TSHR, has good inhibitory activity in vitro and in vivo experiments, and has broad application prospects in the development of treatment of Graves' diseases.

The invention relates to the technical field of medical instruments, in particular to a cornea protection eyeshade for a patient with hyperthyroidism eye disease, which comprises an eyeshade main body, the eyeshade main body comprises a support frame, a protection cover and a fitting layer are mounted on two sides of the support frame, and a self-adaptive fitting adjusting assembly, a multifunctional linkage module and a magnetic suction buffer assembly are further mounted on the support frame. The self-adaptive fitting adjusting assembly is used for driving the fitting layer to adapt to eye contours of different patients, the multifunctional linkage module is used for achieving switching of eye moisturizing and one-way light transmission of the patients, the magnetic attraction buffering assembly is used for relieving compression during wearing and fixing, and the monitoring assembly is installed on the fitting layer and used for monitoring state information of the eye contours of the patients. The monitoring assembly is in signal connection with a controller, and the controller is used for manually adjusting the moisturizing amount and the light transmission mode of the multifunctional linkage module according to the state information. According to the method, full-scene and personalized cornea protection is provided for a patient with hyperthyroidism synophthalmia, and the cornea is prevented from being damaged by exposure, dryness, strong light or compression.

The utility model discloses a cornea protection eyeshade structure for a patient suffering from hyperthyroidism eye diseases in the endocrinology department. The protection eyeshade aims to solve the technical problems that in the prior art, functionality is poor, the patient cannot be conveniently assisted in eye ice compress, and the wearing comfort is poor. Comprise a glasses frame, glasses legs, a first assembling plate and a second assembling plate, the glasses legs are movably connected to the glasses frame, connecting pieces are arranged between the first assembling plate and the glasses frame and between the second assembling plate and the glasses frame, a connecting plate is arranged on one side of the first assembling plate, an elastic assembly is arranged between the connecting plate and the first assembling plate, and a cotton bag is assembled on the side wall of the connecting plate; according to the multifunctional nursing bed, different functional assemblies are arranged, a patient can use the multifunctional nursing bed in different states, the protection effect can be improved, and the nursing effect can be achieved.

The invention discloses a traditional Chinese medicine composition for treating hyperthyroidism and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating hyperthyroidism is prepared from cyclodextrin grafted modified hollow mesoporous organic silicon nanoparticles, traditional Chinese medicine ferment powder and a traditional Chinese medicine extracting solution, the cyclodextrin-grafted modified hollow mesoporous organic silicon nano-particles are used as a carrier, traditional Chinese medicine ferment powder and a traditional Chinese medicine extracting solution are loaded, the medicine concentration of a focus part is increased, traditional Chinese medicine ingredients are rapidly released through rapid response fracture of tetrasulfide bond functional groups, and the traditional Chinese medicine composition is prepared in an active targeting and fixed-point blasting mode. The bioavailability and the onset time of the medicine are improved, the leakage risk of the medicine is jointly reduced through the gating effect of cyclodextrin and responsive release of tetrasulfide bonds, synthesis of thyroid hormone is more thoroughly inhibited under the precise effect of high-concentration medicine and multi-target immunoregulation of traditional Chinese medicine, and the recurrence rate of hyperthyroidism is reduced.

The invention discloses a novel application of a kudzuvine root powder-based iodine complex in preparation of a medicine for preventing or treating hyperthyroidism. Experimental research shows that compared with a traditional iodine preparation, the radix puerariae powder-based iodine compound can achieve effective loading and stable wrapping of iodine and can effectively reduce the concentration of free iodine, so that the direct stimulation and injury risk of iodine to gastrointestinal mucosa is greatly reduced, the tolerance and compliance of patients taking medicine for a long time are remarkably improved, and the curative effect is good. The medicine is suitable for long-term health management of hyperthyroidism patients, and a novel treatment choice which is safe, stable, convenient and good in tolerance is provided for long-term medicine intervention of hyperthyroidism.

The invention relates to the technical field of biological medicines, in particular to application of N-acetylcysteine in preparation of a medicine for improving intestinal injuries caused by diabetic hyperthyroidism complicated diseases, and the N-acetylcysteine is used for preparing the medicine for improving the intestinal injuries caused by the diabetic hyperthyroidism complicated diseases. The traditional Chinese medicine composition can effectively relieve abnormal blood glucose rise of diabetic hyperthyroidism complications, and improve excessive ingestion and drinking conditions and intestinal injury.

The utility model provides an eyeshade for a patient with hyperthyroidism exophthalmos, which relates to the technical field of medical instruments and comprises a pair of eyeshade bodies, a connecting mechanism is mounted on the adjacent sides of the pair of eyeshade bodies, and a primary binding belt and a secondary binding belt are respectively arranged on the outer walls, far away from the connecting mechanism, of the pair of eyeshade bodies. The binding mother belt comprises a first belt body, a belt penetrating box, a cavity, conveniently-torn belts and hook-and-loop fasteners, the two sides of the first belt body are connected with the conveniently-torn belts respectively, the adjacent sides of the two conveniently-torn belts are connected with the hook-and-loop fasteners respectively, the cavity is formed in the first belt body, one end of the cavity is communicated with the belt penetrating box, and the other end of the cavity is communicated with the hook-and-loop fasteners. The binding sub-band comprises a second band body and magic sub-tapes, the two sides of the outer wall of the second band body are connected with the magic sub-tapes respectively, and the connecting mechanism comprises a first connecting seat, a second connecting seat and a pin shaft. The device is simple and reasonable in structure, novel in design, simple and convenient to operate and high in practical value.

The invention discloses an anti-thyroid stimulating hormone monoclonal antibody and a preparation method and application thereof, and relates to the technical field of monoclonal antibody preparation, comprising: heavy chain variable region amino acid sequences SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4; light chain variable region amino acid sequences SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8; the rabbit monoclonal antibody involved in the invention is used as an important raw material for diagnosis, has higher affinity than traditional mouse monoclonal antibodies, can greatly improve the sensitivity of detection reagents, has a higher clinical compliance rate, and has important clinical significance for the diagnosis and treatment of diseases such as primary hyperthyroidism, thyroid cancer, and thyroid nodules.

The invention discloses a traditional Chinese medicine patch for conditioning yin deficiency constitution and preparation and application of the traditional Chinese medicine patch, the traditional Chinese medicine patch comprises, by weight, 5-10 g of chrysanthemum, 6-9 g of folium mori and other medicinal materials which are compatible with one another, and the effects of nourishing yin and clearing heat are achieved together. The preparation method comprises the steps of medicinal material screening treatment, low-temperature crushing, mixing and stirring, packaging and the like, so that effective components of medicinal materials are scientifically and rigorously reserved. During use, 2-6 patches are selected to be applied to corresponding acupuncture points according to symptoms, about 6 hours are taken each time, and 5 days are taken as a course of treatment. The traditional Chinese medicine patch can be used for preparing medicines for treating insomnia, constipation, hyperthyroidism and other diseases, and clinical cases show that the traditional Chinese medicine patch can effectively improve yin deficiency related symptoms. The external application mode avoids the defect of oral administration, and a new effective way is provided for conditioning the constitution with yin deficiency.

Hyperthyroid diarrhea refers to hyperthyroid diarrhea, which is mostly intractable diarrhea, due to excessive thyroid hormone causing increased intestinal peristalsis excitability and diarrhea when the thyroid function is increased, which is caused by endocrine metabolic disorder leading to gastrointestinal function disorder. The present application studies and observes the treatment effect of kaempferol coupling derivative JC-1 on diarrhea of hyperthyroid model mice, and provides a new drug treatment option for diarrhea type colon dysfunction.

The utility model discloses an eye nursing device for a patient with hyperthyroidism synapse. The eye nursing device comprises an eyeshade frame body, a toothed plate and an elastic band, a nylon lens is arranged in the eyeshade frame body, and a lens belt is connected to one side of the eyeshade frame body; the toothed plate is arranged on one side of the nylon lens, and the surface of the toothed plate is engaged with a first gear; the rotary knob drives the polish rod to rotate, the polish rod rotates to wind an elastic band on the surface of the polish rod, the elastic band is tightened, a pull plate is rotated reversely, a threaded rod drives a semicircular toothed plate to move downwards, the semicircular toothed plate is meshed with a second gear, the polish rod can be fixed, and the elastic band is prevented from running out; the eye nursing device can be effectively protected by tightening the elastic band, and the falling of the eye nursing device is reduced; the rotating disc drives the rotating rod and the first gear to rotate, so that the nylon lens can be driven to move upwards, the nylon lens is exposed out of the surface of the empty groove, and an operator takes out the nylon lens so as to clean or replace the nylon lens.

The utility model aims to provide a tightness-adjustable hyperthyroidism eye protection device, and relates to the technical field of medical instruments, a telescopic cylinder is fixedly arranged on a mirror frame, so that wind and sand around eyes can be blocked, and a flexible sleeve attached to an eye structure is arranged at one end of the telescopic cylinder, so that the telescopic cylinder can be well attached to the periphery of an eye socket, and the safety of the eye is improved. The distance between the lenses and the eyes can be adjusted according to the eye protrusion condition of a patient through stretching and retracting of the telescopic cylinders and stretching and retracting of the glasses legs, so that contact between the lenses and the eyes is avoided, the distance between the glasses frames can be adjusted according to the distance between the two eyes of different patients through the design of the telescopic connecting beams at the two ends, and the glasses can better adapt to different patients; and the positions of the nose pads can be adjusted according to the stretching of the telescopic cylinders through the stretching of the telescopic rods of the support frame, so that the nose pads can be supported on the nose bridge.

The invention discloses a traditional Chinese medicine compound composition for treating hyperthyroidism as well as a preparation method and application of the traditional Chinese medicine compound composition. The traditional Chinese medicine compound composition is prepared from the following raw materials: 3-17 parts of cortex moutan, 6-26 parts of polygonum cuspidatum, 3-17 parts of radix curcumae, 6-26 parts of fried rhizoma atractylodis macrocephalae, 8-32 parts of parched white paeony root, 4-20 parts of rhizoma pinellinae praeparata, 3-17 parts of fried szechwan chinaberry fruit, 6-26 parts of oriental wormwood, 1-11 parts of honey-fried polygala tenuifolia, 8-32 parts of selfheal, 3-17 parts of fructus forsythiae, 6-26 parts of radix scrophulariae, 13-47 parts of calcined oyster shell and 8-32 parts of kelp. The composition is screened and determined under the guidance of traditional Chinese medicine theories in combination with modern research progress (especially the latest research conclusion of treating the disease by iodine-containing drugs), and clinical experiment results show that the composition has better effects of reducing TSH and the like and improving symptoms of patients, and is good in safety. And compared with methimazole for treating hyperthyroidism, the composition has better effects of reducing TRAb and FT3 and improving symptoms of patients.

The present disclosure relates to a method and related products for training a model for identifying hyperthyroidism. The method is implemented by a computing device and includes: acquiring healthy fundus images and fundus images of patients with hyperthyroidism; performing quality screening on the healthy and hyperthyroid fundus images to obtain a first training set of fundus images without auxiliary information and a second training set of fundus images containing the auxiliary information; and training a model for identifying hyperthyroidism based on fundus images based on the first and second training sets. Using the disclosed solution, hyperthyroidism can be efficiently identified based on fundus images.

An oral non-aqueous solution of carbimazole comprising carbimazole or pharmaceutically acceptable salts thereof in an amount of 1 mg / mL to 10 mg / mL is provided. The solution may further comprise an an

The invention discloses a traditional Chinese medicine acupoint application with a thyroid function improving function, a preparation method and application of the traditional Chinese medicine acupoint application with the thyroid function improving function. The traditional Chinese medicine composition is prepared from 2g of radix angelicae, 2g of angelica sinensis, 2g of honeycomb, 2g of tangerine seed, 2g of lychee seed, 2g of mirabilite, 2g of selfheal, 2g of spina gleditsiae, 2g of thunberg fritillary bulb, 2g of radix semiaquilegiae and 1g of borneol. The bonding layer is used for fixing the traditional Chinese medicine composition on the substrate material and making contact with the skin, and the substrate material is an air-permeable non-woven fabric material; the traditional Chinese medicine acupoint application has a good thyroid improving effect, can be used for patients with hashimoto thyroid gland, subacute thyroiditis, hypothyroidism, goiter and nodule and hyperthyroidism and is convenient to use clinically, and the important acupoint application provided by the invention has the advantages that in the experiment process, part of patients are allergic to components or dressings, and the traditional Chinese medicine can be applied to the traditional Chinese medicine acupoint application. No obvious toxic or side effect is found, so that the safety is better.

The invention relates to application of cannabidiol in preparation of a medicine for adjuvant therapy of hyperthyroidism, and belongs to the technical field of biological medicine. The invention aims to provide novel medical application of cannabidiol, namely application of cannabidiol in preparation of a medicine for adjuvant therapy of hyperthyroidism. Animal model in-vivo experiments prove that cannabidiol has a sedative effect on hyperthyroidism mice, can inhibit hyperactivity caused by hyperthyroidism and effectively relieve symptoms such as easy excitation, dysphoria and insomnia, is beneficial to emotion stabilization and creates favorable conditions for treatment of hyperthyroidism. Cell in-vitro experiments prove that cannabidiol can effectively block a stress signal channel triggered by corticosterone, relieve the stress reaction degree of liver cells, relieve the liver burden and promote liver function recovery, and a new intervention thought is provided for adjuvant therapy of hyperthyroidism liver injury.

This invention provides the application of NDV in the preparation of drugs for treating hyperthyroidism, belonging to the field of pharmaceutical technology. This invention discovers that the cytotoxic effect of NDV is significantly time-dependent, with the killing effect gradually increasing with prolonged culture time. Furthermore, this invention is the first to discover that NDV can significantly enhance the cytotoxic ability of JAK inhibitors against thyroid follicular epithelial cells, effectively inhibit the growth of overactive thyroid cells, and induce apoptosis. This not only overcomes the limitation of JAK inhibitors alone in killing thyroid epithelial cells, but also reduces the cells' natural resistance to NDV by inhibiting the JAK-STAT pathway, thus strengthening the lytic effect of oncolytic viruses on hyperactive thyroid cells, providing a novel drug combination strategy with a synergistic mechanism for the treatment of hyperthyroidism.

The invention discloses a bone loss comprehensive prevention and control system in hyperthyroidism treatment, and relates to the technical field of intelligent medical treatment, and the system collects hormone indexes, bone metabolism indexes, bone density imaging data and parathyroid hormone related indexes of a patient through a multi-modal perception input module, and carries out normalization and vector coding to form multi-modal perception data. The system generates a ternary atlas through a graph structure construction module, introduces a graph attention mechanism to optimize node weight, and constructs a hyperthyroidism treatment atlas. The graph neural network prediction module predicts a fracture risk value and a bone mineral density change trend based on a graph convolutional network. The endocrine regulation and control feedback module combines the multi-mode data and the prediction parameters to calculate the bone conversion rate and generate individualized blocking control signals. And the intervention path optimization module generates an optimal drug combination, nutritional supplement and behavior intervention path through a reinforcement learning model. The system has the advantages of high-precision prediction capability and intelligent intervention decision, and is suitable for dynamic management of hyperthyroidism-related osteoporosis.

The invention relates to the technical field of photophobic nursing, in particular to a photophobic device for hyperthyroidism eye nursing, which comprises a box body, connecting rods are symmetrically and fixedly connected to the bottom of the box body, and spectacle lenses are fixedly connected to the ends, away from the box body, of the connecting rods. And a fixing assembly is arranged on the box body. A storage assembly is arranged in the box body. Each spectacle lens is provided with a shielding assembly, a sealing assembly, an adjusting assembly, a pressurizing assembly and a spraying assembly. The shielding assembly comprises a first shielding piece which is fixedly connected to the inner side of the spectacle lens. Sliding blocks are in sliding fit with the spectacle lenses in the circumferential direction, second shielding pieces are fixedly connected to the sliding blocks, sliding columns are fixedly connected to the sides, away from the sliding blocks, of the second shielding pieces, and the sliding columns are in sliding fit with the adjusting assembly. A patient is helped to perform basic shading through the first shading piece, and the patient can adjust the position of the second shading piece through the poke rod according to the intensity of light, so that the shading effect on the light is enhanced, and the situation that inflammation of the eyes of the patient is aggravated is reduced.

The invention relates to the technical field of medical treatment and public health, and discloses a decoction and a hot compress bag for dredging treatment of a whole-body clogging point, and a corresponding pushing and pressing technology. The decoction is composed of the following raw materials by weight: 40 g of dried ginger slices, 3 g of licorice, 3 g of red dates, 3 g of Chinese wolfberry, 5 g of ginseng, and 2.5 L of water. The hot compress bag comprises a bag body and a traditional Chinese medicine bag placed in the bag body, and the bag body is filled with ores and / or red beans. According to the decoction and the hot compress bag for dredging treatment of the whole body clogging point, the decoction for oral administration and the hot compress bag for external application are combined with corresponding pushing and pressing methods for combined use, various diseases caused by clogging of organs and tissues of a patient can be effectively treated, and three highs (hyperlipidemia, hyperglycemia and hypertension), leukemia, rheumatoid arthritis and lupus erythematosus can be effectively improved and cured; , hyperthyroidism, hypothyroidism, andrology and gynecology diseases. The traditional Chinese medicine composition has the advantages of obvious effect, high cure rate, rapid improvement of immune function of patients, improvement of disease resistance, safety, effectiveness and no toxic or side effect.

This invention discloses a method and system for microwave ablation therapy of refractory hyperthyroidism based on structure-function bimodal imaging guidance. The method includes: fusing preoperative contrast-enhanced ultrasound images of the thyroid gland with radionuclide imaging of its functional metabolic components using a deep learning registration network to output an individualized ablation plan containing the ablation target area and safety boundaries; performing the first microwave ablation under real-time ultrasound guidance according to the individualized ablation plan, generating sites and energy parameters requiring supplementary ablation during the procedure; performing postoperative SPECT / CT dynamic imaging on patients after supplementary ablation to obtain the technetium uptake distribution and three-dimensional anatomical localization of residual thyroid tissue, outputting functional active area localization data; and performing targeted supplementary ablation on the residual active tissue area based on the functional active area localization data. Using this invention, the effectiveness and safety of ablation therapy for refractory hyperthyroidism can be improved, and the recurrence rate and incidence of hypothyroidism can be reduced.

The invention discloses a medical hyperthyroidism protrusion eye nursing device which structurally comprises a mirror frame, a disassembly and assembly frame, a shell and a timing mechanism, the disassembly and assembly frame is installed in the upper end of the mirror frame in an inserted connection mode, the shell is fixedly installed between the two disassembly and assembly frames, and the timing mechanism is further arranged between the two disassembly and assembly frames. A power supply is started at regular time through a timer to provide power for a micro motor, so that the micro motor drives a driving shaft and a worm to rotate at regular time, a lifting plate descends at regular time, a lifting pressing plate presses downwards at regular time, and eye drops stored in two liquid storage pipes flow downwards from liquid guide pipes at regular time to drop the two eyes of a patient; discomfort caused by dry eyes of a patient can be effectively prevented; the sunglasses lenses are inserted and mounted in the glasses frame, the clamping rods are connected with the interiors of the side connecting plates in a clamped mode, the sunglasses lenses can conduct sunscreen protection on the eyes of a patient, and discomfort of the eyes of the patient caused by dazzling sunlight is avoided.

The invention provides a hyperthyroidism patient nursing bed which comprises a nursing bed body, universal wheels are installed at the bottom of the nursing bed body, a front bed baffle is installed on the front side of the upper surface of the nursing bed body, a universal metal pipe is installed on the top side of the front bed baffle, and a massage piece is installed on the top of the universal metal pipe. A sliding groove is formed in the rear surface of the nursing bed, and a rear bed baffle is slidably connected into the sliding groove. According to the device, the lying posture of a patient lying on the side is achieved through the arranged adjusting piece, the upper body of the patient can be adjusted by a certain angle through the lifting piece, the patient can semi-sit and lie through the adjusting rod, the third screw, the front sliding disc and the outer protruding cylinder, the shoulders can be massaged through the arranged massage piece, and the massage effect is good. And through a rotating handle arranged in the supporting plate, the wrist developer can be used for rehabilitation training.

This invention relates to the field of protective eyewear technology, specifically a light-shielding device for the care of Graves' ophthalmopathy. It includes a fixing component for securing to the head and a light-shielding component for blocking light from the eyes. The light-shielding component and the fixing component are connected by a first connecting structure. The fixing component includes an arc-shaped fixing plate and connecting straps at both ends of the arc-shaped fixing plate, with the ends of the two connecting straps connected by Velcro. Two sets of light-shielding components are provided, each including a fixing sleeve and multiple mounting sleeves. The multiple mounting sleeves are connected to each other and to the fixing sleeves via a second connecting structure. The inner and outer diameters of the mounting sleeves and the fixing sleeves are equal. A light-shielding plate is disposed inside each mounting sleeve. By installing or removing the mounting sleeves, the number of light-shielding plates can be adjusted, allowing for rapid adjustment of the overall light-shielding effect, making it suitable for different patients.

The utility model relates to an eyeshade, in particular to an endocrinology department hyperthyroidism cornea protection eyeshade. The utility model discloses an endocrinology department hyperthyroidism cornea protection eyeshade with a long-time moisturizing function. A hyperthyroidism cornea protection eyeshade for the endocrinology department comprises an eyeshade body, a liquid storage bottle, a filling pipe, an eyeshade protection patch, a catheter and the like, a groove used for containing protruding eyeballs is formed in the inner side of the eyeshade body, the liquid storage bottle is arranged in the middle of the inner side of the eyeshade body, and the upper portion of the liquid storage bottle is connected and communicated with the filling pipe. Eye protection patches used for moisturizing the eyes are attached to the interiors of the two grooves respectively, and the eye protection patches are connected and communicated with the liquid storage bottle through guide pipes. A proper amount of liquid is injected into the liquid storage bottle, and under the communication action of the guide pipe, the liquid in the liquid storage bottle can permeate into the eye protection patch, so that when a patient wears the eye protection patch, the eye of the patient can be moisturized for a long time, and the eye of the patient can be effectively prevented from being dry or uncomfortable.