Pharmaceutical application of rapamycin in refractory graves disease

A rapamycin, refractory technology, applied in the field of pharmaceutical application of rapamycin in refractory Graves disease, can solve the problems such as the unreported therapeutic application of rapamycin, and achieve the improvement of plasma level. Effect

Active Publication Date: 2021-12-07
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the application of rapamycin in the treatment of refractory Graves disease has not been reported

Method used

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  • Pharmaceutical application of rapamycin in refractory graves disease
  • Pharmaceutical application of rapamycin in refractory graves disease
  • Pharmaceutical application of rapamycin in refractory graves disease

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Embodiment Construction

[0028] In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0029] It should be noted that the terms "first" and "second" in the description and claims of the present invention and the above drawings are used to distinguish similar objects, but not necessarily used to describe a specific sequence or sequence. It is to be understood that the data so used are interchangeable under appropriate ...

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Abstract

The present invention discloses for the first time the pharmaceutical application of rapamycin in the treatment of refractory GD. The combined treatment of rapamycin + methimazole can improve the TSH and TRAb levels of patients with refractory GD; and, the Treg / CD4+ in patients The ratio of T increased, the ratio of Th17 / CD4+T and the ratio of Th17 / Treg decreased; at the same time, the plasma levels of Th17 and Treg cell-related cytokines, including IL-17A, IL-6 and TGF-β1, were significantly improved. The dose of rapamycin for refractory GD is 0.5 mg / day, and the trough concentration of the drug is 2-4 ng / mL. There were no obvious adverse reactions in the combined treatment group of rapamycin + methimazole. Therefore, the experimental results of the present invention fully support the new application of rapamycin in the treatment of refractory GD, and the combined treatment of rapamycin + methimazole is a new direction for the treatment of refractory GD worth exploring.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to the pharmaceutical application of rapamycin in refractory Graves' disease. Background technique [0002] Graves' disease (GD) is a common organ-specific autoimmune disease and the most common cause of hyperthyroidism. The annual incidence of GD is (20-50) / 100,000, and about 3% of women and 0.5% of men suffer from GD for life. Among them, GD patients who received antithyroid drug therapy for more than 5 years, and those with normal or mild hyperthyroidism were defined as refractory GD. Based on our previous studies, refractory and regulatory T cells (Treg) / CD4+T, Th17 / CD4+T ratio, and Th17 / Treg ratio in GD compared with GD group in remission and healthy control group Moreover, the expression levels of Th17 and Treg cell-related cytokines IL-17A, IL-6, TGF-β1, IL-1β and IL-10 in plasma of refractory GD patients were significantly higher than those of healthy controls. At presen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/436A61K31/4164A61P37/02A61P5/14
CPCA61K31/4164A61K31/436A61P5/14A61P37/02A61K2300/00
Inventor 施秉银王悦陈子怡胡诗倩
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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