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Pharmaceutical composition for treating hyperthyroidism, including its preparation and its preparation method and application

A composition and medicine technology, applied in the field of medicine, can solve the problems of lifelong hypothyroidism, slow effect of traditional Chinese medicine treatment, easy to appear poisoning symptoms, etc., and achieve the effects of shortening the course of treatment, alleviating the pain of patients, and low cost

Active Publication Date: 2020-04-07
蚌埠丰原涂山制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] ④ When taking lithium carbonate, the blood lithium concentration is high, which is prone to poisoning symptoms, such as encephalopathy syndrome, shock, renal function damage, etc.; when the blood lithium concentration is too high, it may be life-threatening
[0014] ⑤ The recurrence rate of hyperthyroidism is high in the treatment of antithyroid drugs, the adverse reactions are large, and patients cannot tolerate it
Surgery and radioactive iodine may lead to lifelong hypothyroidism
[0015] ⑥The effect of traditional Chinese medicine treatment is slow and the treatment time is long

Method used

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  • Pharmaceutical composition for treating hyperthyroidism, including its preparation and its preparation method and application
  • Pharmaceutical composition for treating hyperthyroidism, including its preparation and its preparation method and application
  • Pharmaceutical composition for treating hyperthyroidism, including its preparation and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: the pharmaceutical composition for the treatment of hyperthyroidism

[0057] 1. Raw materials:

[0058] raw material Weight (kg) weight percentage (%) Methimazole 0.09 0.02 kelp 40 8.89 Fritillaria 40 8.89 Job's tears 50 11.11 Eucommia 50 11.11 dogwood 50 11.11 Chuanxiong 40 8.89 Xanthogonia 50 11.11 angelica 70 15.55 light tempeh 60 13.33 total 450.09 100

[0059] 2. Preparation method:

[0060] 1) Weigh each raw material according to the proportion.

[0061] 2) Extract Fritillaria fritillaria, Eucommia ulmoides, and Chrysanthemum officinalis with 60% ethanol once, add ethanol 6 times the weight of medicinal materials each time, and extract for 3 hours each time, combine the extracts, filter, and recover ethanol under reduced pressure to obtain Alcoholic extract, spare.

[0062] 3) Extract kelp, coix seed, dogwood, chuanxiong, angelica, and tempeh with water t...

Embodiment 2

[0064] Embodiment 2: the pharmaceutical composition for the treatment of hyperthyroidism

[0065] 1. Raw materials:

[0066] raw material Weight (kg) weight percentage (%) Methimazole 0.06 0.02 kelp 28 7.23 Fritillaria 40 10.33 Job's tears 35 9.04 Eucommia 50 12.92 dogwood 35 9.04 Chuanxiong 40 10.33 Xanthogonia 50 12.92 angelica 49 12.66 light tempeh 60 15.50 total 387.06 100

[0067] 2. Preparation method:

[0068] 1) Weigh each raw material according to the proportion.

[0069] 2) Extract Fritillaria fritillaria, Eucommia ulmoides, and Chrysanthemum officinalis 2 times with 70% ethanol, add ethanol 7 times the weight of the medicinal materials each time, and extract for 2 hours each time, combine the extracts, filter, and recover ethanol under reduced pressure to obtain Alcoholic extract, spare.

[0070] 3) Extract kelp, coix seed, dogwood, chuanxiong, angelica, and tempeh with ...

Embodiment 3

[0072] Embodiment 3: the pharmaceutical composition for the treatment of hyperthyroidism

[0073] 1. Raw materials:

[0074]

[0075]

[0076] 2. Preparation method:

[0077] 1) Weigh each raw material according to the proportion.

[0078] 2) Extract Fritillaria fritillaria, Eucommia ulmoides, and Chrysanthemum officinalis 3 times with 80% ethanol, add ethanol 8 times the weight of the medicinal materials each time, and extract for 1 hour each time, combine the extracts, filter, and recover ethanol under reduced pressure to obtain Alcoholic extract, spare.

[0079] 3) Extract kelp, coix seed, dogwood, chuanxiong, angelica, and tempeh with water 4 times, add water 10 times the weight of the medicinal materials each time, decoct for 1 hour, combine the decoction, filter, and concentrate under reduced pressure , to obtain the water extract, and set aside.

[0080] 4) Methimazole, the above-mentioned ethanol extract, and the above-mentioned water extract are prepared int...

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Abstract

The invention relates to a pharmaceutical composition for treating hyperthyroidism, a preparation containing the same, a preparation method and application thereof. The pharmaceutical composition contains the following active components in parts by weight: 6-12 parts of methimazole, 2800-5200 parts of kelp, 2800-5200 parts of thunberg fritillary bulb, 3500-6500 parts of coix seeds, 3500-6500 parts of cortex eucommiae, 3500-6500 parts of dogwood, 2800-5200 parts of hemlock parsley, 3500-6500 parts of airpotato yam, 4900-9100 parts of angelica sinensis and 4200-7800 parts of fermented soybeans. The pharmaceutical composition for treating hyperthyroidism provided by the invention adopts a method with combination of Chinese traditional and western medicine, gives full play to the synergistic effect of Chinese traditional and western medicine, reduces adverse reaction of the pharmaceutical composition, enhances the curative effect, shortens the course of treatment and increases tolerance of patients.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a medicine composition for treating hyperthyroidism, including its preparation and its preparation method and application. Background technique [0002] Western medicine believes that a group of clinical syndromes mainly manifested as increased excitability and hypermetabolism in the nervous, circulatory, and digestive systems caused by excessive thyroid hormone in the blood circulation is called thyrotoxicosis; due to the hyperfunction of the thyroid gland itself, the thyroid Thyrotoxicosis caused by increased hormone synthesis and secretion is called hyperthyroidism, referred to as hyperthyroidism. [0003] Thyroid disease has a certain genetic predisposition, and the incidence rate is higher in women, people with family history, mental trauma and infection. The causes of hyperthyroidism include: infection; trauma, trauma; mental stimulation; excessive fatigue; e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61P5/16A61K31/4164
CPCA61K31/4164A61K36/03A61K36/232A61K36/236A61K36/40A61K36/46A61K36/48A61K36/8945A61K36/8966A61K36/8994A61K2236/331A61K2236/333A61K2300/00
Inventor 马其胜李保琴孙鹏
Owner 蚌埠丰原涂山制药有限公司
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