Application of alfacalcidol in preparing external preparation for intervening in skin light injury

A technology for alfacalcidol and external preparations, which is applied in skin diseases, medical preparations containing active ingredients, drug delivery, etc., to achieve broad clinical application prospects, reduce degradation, and improve the effects of proliferation activity
CN111743906AInactive Publication Date: 2020-10-09南通华山药业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
南通华山药业有限公司
Publication Date
2020-10-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an application of alfacalcidol in preparing an external medicine for preventing and / or treating skin light injury. The alfacalcidol in the invention can improve the proliferation activity of fibroblasts; the expression of MMP-1 and MMP-3 can be inhibited, and the degradation of an extracellular matrix is reduced; the skin light injury symptom can be obviously relieved; thecompound can be used for preparing external medicines for intervening in skin light injury, and has a wide clinical application prospect.
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Description

technical field

[0001] The invention specifically relates to an application of alfacalcidol in the preparation of an external preparation for intervening skin photodamage. Background technique

[0002] On a daily basis, parts of the human body are exposed to sunlight. Due to different lifestyles and work types, excessive sun exposure can cause a series of damage to the skin, which is mainly caused by excessive exposure to ultraviolet rays in the sun, especially medium-wave ultraviolet (UVB). The wavelength of UVB is 290-320nm, with medium penetrating power. Most of the UVB contained in sunlight is absorbed by the ozone layer, and less than 2% can reach the surface of the earth, which is particularly strong in summer and afternoon. UVB has an erythema effect on the human body. Although it can promote mineral metabolism and the formation of vitamin D in the body, long-term or excessive exposure can induce skin erythema, blisters, inflammation, roughness, thickening, pigmentat...

Claims

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