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Application of alfacalcidol in preparing external preparation for intervening in skin light injury

A technology for alfacalcidol and external preparations, which is applied in skin diseases, medical preparations containing active ingredients, drug delivery, etc., to achieve broad clinical application prospects, reduce degradation, and improve the effects of proliferation activity

Inactive Publication Date: 2020-10-09
南通华山药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there is no report on the use of alfacalcidol to repair skin photodamage

Method used

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  • Application of alfacalcidol in preparing external preparation for intervening in skin light injury
  • Application of alfacalcidol in preparing external preparation for intervening in skin light injury
  • Application of alfacalcidol in preparing external preparation for intervening in skin light injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A representative external preparation for intervening skin photodamage, which is composed of the following ingredients: 3.5% alfacalcidol, 49% purified water, 10% 1,2-propylene glycol, 5% ethanol, polydimethylformaldehyde Silicone 7%, PEG 8000 25%, Methylparaben 0.5%. The percentages of the above substances are mass ratios.

[0026] The preparation method is as follows:

[0027] (1) Heating alfacalcidol, 1,2-propanediol, ethanol and methylparaben in the prescribed amount to 50° C. fully dissolves into a clear and transparent solution, which is mixture A;

[0028] (2) After heating the purified water, polydimethylsiloxane and PEG 8000 to 50°C, fully homogenize with mechanical stirring, and obtain mixture B;

[0029] (3) Slowly add mixture A to mixture B while stirring at a high speed while it is hot, stir evenly and then cool down to room temperature to obtain the external preparation described in this example.

[0030] How to use: Take an appropriate amount and apply...

Embodiment 2

[0032] A representative external preparation for intervening skin photodamage, which is composed of the following ingredients: 3.5% alfacalcidol, 44% purified water, 9% 1,2-propanediol, 6% ethanol, polydimethylformaldehyde Silicone 7%, glyceryl monostearate 15%, polyoxyethylene castor oil (Cremophor EL) 15%, methylparaben 0.5%. The percentages of the above substances are mass ratios.

[0033] The preparation method is as follows:

[0034] (1) Heating alfacalcidol, 1,2-propanediol, ethanol and methylparaben in the prescribed amount to 50° C. fully dissolves into a clear and transparent solution, which is mixture A;

[0035] (2) After heating purified water, polydimethylsiloxane, glyceryl monostearate, and polyoxyethylene castor oil (CremophorEL) to 50°C, mechanically stir and fully homogenize to form mixture B;

[0036] (3) Slowly add mixture A to mixture B while stirring at a high speed while it is hot, stir evenly and then cool down to room temperature to obtain the externa...

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PUM

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Abstract

The invention discloses an application of alfacalcidol in preparing an external medicine for preventing and / or treating skin light injury. The alfacalcidol in the invention can improve the proliferation activity of fibroblasts; the expression of MMP-1 and MMP-3 can be inhibited, and the degradation of an extracellular matrix is reduced; the skin light injury symptom can be obviously relieved; thecompound can be used for preparing external medicines for intervening in skin light injury, and has a wide clinical application prospect.

Description

technical field [0001] The invention specifically relates to an application of alfacalcidol in the preparation of an external preparation for intervening skin photodamage. Background technique [0002] On a daily basis, parts of the human body are exposed to sunlight. Due to different lifestyles and work types, excessive sun exposure can cause a series of damage to the skin, which is mainly caused by excessive exposure to ultraviolet rays in the sun, especially medium-wave ultraviolet (UVB). The wavelength of UVB is 290-320nm, with medium penetrating power. Most of the UVB contained in sunlight is absorbed by the ozone layer, and less than 2% can reach the surface of the earth, which is particularly strong in summer and afternoon. UVB has an erythema effect on the human body. Although it can promote mineral metabolism and the formation of vitamin D in the body, long-term or excessive exposure can induce skin erythema, blisters, inflammation, roughness, thickening, pigmentat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/593A61P17/16
CPCA61K9/0014A61K31/593A61P17/16
Inventor 施建飞钱建
Owner 南通华山药业有限公司
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