246 results about "Micro-encapsulation" patented technology

A tablet that rapidly disintegrates in the oral cavity comprising a compressed blend of rapidly dispersing microgranules prepared by granulating a sugar alcohol or a saccharide or a mixture thereof having an average particle size less than about 30 microns and a disintegrant, and a taste-masked microcapsule containing at least one drug, the microcapsule being prepared by granulating a pharmaceutically acceptable formulation comprising at least one drug in a therapeutically effective amount and at least one polymeric binder that improves resilience of the microgranules, wet milling the granulated mass, and microencapsulating the milled granules to provide microcapsules.

There is provided an orally-administrable formulation for the controlled release or stable storage of a granulated isoflavone-enriched fraction or mixture of such fractions, comprising at least one granulated isoflavone-enriched fraction and at least one carrier, diluent or excipient therefor. Preferably, the formulation is characterized in that the total in vitro dissolution time of said formulation required for release of 75% of the active ingredients available from the formulation is between about 4 and about 18 hours, as determined by the U.S.P. XXIII paddle method at a paddle speed of 75 rpm, using simulated intestinal fluid without the digestive enzymes normally found in intestinal fluid, at pH 6.8, and a temperature of 37° C. A process for the preparation of such a formulation is also provided.

A probiotic composition essentially comprises 15 to 20 wt % of milk powder, 25 to 30 wt % of corn starch, 8 to 15 wt % of modified starch (capsul), 10 to 15 wt % of ethylcellulose, 5 to 15 wt % of bacterial broth, and 10 to 15 wt % of talc. The probiotic composition is microencapsulated to form a plurality of microencapsule coated with an acid-resistant enteric coating for improving the enteric acid-resistance, the probiotic survival rate, the antimicrobial property, the stability, the moisture-proof property, and the mobility of the probiotic composition preventing from coagulation in a moist environment and for being used as an additive applied to livestock feed.

The invention relates to a preparation method for a photochromic micro encapsulant, belonging to technical field of functional macromolecular materials, which comprises following steps: dissolving the photochromic micro encapsulant in organic solvent to obtain photochromic solution; completely dissolving emulsifier, adding the photochromic solution, then emulsion is obtained after the emulsification of mixed solution; adding melamine resin prepolymer in emulsion; adjusting the pH value 3 to 6; adding dispersing agent, then the photochromic micro encapsulant is obtained through cleaning and drying. The preparation method for the photochromic micro encapsulant has the advantages of ability to greatly reduced harm to the health of human body and environmental pollution, simple operation process, improved acid and alkaline resistance and fatigue resistance of chromic material, prolonged service life, good photochromic properties and fast discoloration and decoloration of the prepared micro encapsulant, and wide application prospect in anti-counterfeit and textile field.

The invention relates to a suspension seed coating which comprises an insecticide and a bactericide. In the suspension seed coating, active ingredients with insecticidal and bactericidal activity exist in a microcapsule. After the seeds coated by the microencapsulated seed coating are sown, the active ingredients can be slowly released, thus prolonging the effect lasting period of the active ingredients.

The invention discloses a fruit and vegetable micro encapsulated fresh-keeping agent, which is prepared from chitosan, propolis and beta-cyclodextrin which are used as wall materials and cassia oil, rosemary oil and lemon oil which are used as core materials. The fruit and vegetable micro encapsulated fresh-keeping agent is prepared by the following steps of: adding the beta-cyclodextrin and water in a three-port bottle; electrically stirring and heating to 60-70DEG C for dissolving the beta-cyclodextrin into the water; continuously stirring and cooling to 40-45DEG C; adding the core materials of the cassia oil, the rosemary oil and the lemon oil to ensure that the mixed essential oil is uniformly dispersed in solution; then slowly cooling to the room temperature to obtain a beta-cyclodextrin-essential oil microcapsule; adding the mixed wall material of the chitosan and the propolis; adding glycerol and tween-80; and continuously stirring for 30 minutes to form the micro encapsulated fresh-keeping agent. in the invention, the beta-cyclodextrin-essential oil microcapsule is smeared on the surface of the fruit and vegetable by the film forming characteristics of the chitosan and the propolis and an essential oil fresh-keeping agent is continuously released under the action of the microcapsule, so that the aim of keeping the quality of the fruit and vegetable can be achieved.

The invention discloses a bifunctional micro-encapsulation phase-change energy storage material with a photo-catalysis property and a preparation method thereof. A core material of the bifunctional micro-encapsulation phase-change energy storage material is a phase-change material such as high-grade aliphatic alkane, alcohol, acid, acid ester and the like, and a wall material of the bifunctional micro-encapsulation phase-change energy storage material is crystalline titanium dioxide or element-doped crystalline titanium dioxide with the photo-catalysis property. The preparation method comprises the steps of mixing and stirring 2.0-3.4wt.% of surfactant, 79.0-80.0wt.% of solvent, 6.0-10.0wt.% of phase-change energy storage material and 4.5-8.5wt.% of titanium source in percentage by weight to form a stable emulsion; adding mixed liquid of the solvent and water to initiate reaction; then adding 0.0-3.0wt% of crystallization induction additive in percentage by weight to obtain the micro-encapsulation phase-change energy storage material of a crystalline titanium dioxide coated organic phase-change material. The micro-encapsulation phase-change energy storage material of an element-doped crystalline titanium dioxide coated organic phase-change material can be obtained by adding a product into a metal solution or non-metal solution while stirring.

Microencapsulated delivery vehicles comprising an active agent are disclosed. In one embodiment, the microencapsulated delivery vehicles are heat delivery vehicles capable of generating heat upon activation. The microencapsulated heat delivery vehicles may be introduced into wet wipes such that, upon activation, the wet wipe solution is warmed resulting in a warm sensation on a user's skin. Any number of other active ingredients, such as cooling agents and biocides, can also be incorporated into a microencapsulated delivery vehicle.

The present invention provides a method of imparting flavor enhancers, (flavorings) flavor or aroma masking agents, medicinal additives, fragrances, vitamins, colorants, homeopathic and herbal remedies, appearance and characteristic modifiers and other ingredients to a brewed or steeped beverage such as coffee or tea by means of a microencapsulated delivery system incorporated onto a substrate or filter material such as those used in drip coffee makers or tea bags. The microcapsules are “printed” or laminated to the substrate filter paper in a pattern that allows water to pass through while the microcapsules filled with a flavoring liquid or solid is dissolved thus releasing the contents into the water stream resulting in a flavor-enhanced beverage. Alternative delivery may also be achieved by means of:

• • a) A microcapsule coated paper disc that may simply be immersed in the hot beverage or;
  • b) A microcapsule coated interior wall of a disposable container or cup (A paper coffee cup for example) until such time the hot fluid within the container dissolves the microcapsules thus releasing the latent additive ingredient or a primary formulation of ingredients constituting the entire beverage solution or mixture.

Several variations of this technology may be adapted for use with hot, cold or ambient temperature beverage preparation methods. Further aspects of the invention will become apparent from consideration of the drawings and the ensuing description of preferred embodiments of the invention. A person skilled in the art will realize that other embodiments of the invention are possible and that the details of the invention can be modified in a number of respects, all without departing from the inventive concept. Thus, the following drawings, photos and description are to be regarded as illustrative in nature and not restrictive.

The invention discloses the preparation method and uses of carboxymethyl chitosan and sodium alginate blend microcapsule wherein the method comprises, using water as solvent to blend the water solution of carboxymethyl chitosan and sodium alginate into blending liquid I, dissolving the contained medicament bovine serum albumin into the blended solvent I and mixing homogeneously, obtaining blended liquid II, dispersing the blended liquid II into fluid wax containing emulsifying agent, dropping CaCl2 coagulated liquid into the system, charging 10-30 mL alcohol isopropylicum and hardening to obtain micro-encapsulation, which exhibits sensitive response function to the pH changes.

A tobaccoless nicotine delivery device permits delivery of nicotine in a manner similar to a cigarette. The device may include an impermeable outer layer surrounding a micro-encapsulated nicotine layer that includes a measured amount of nicotine in a form that allows nicotine vapor to be released upon rupture of the micro-encapsulation. A permeable membrane may be disposed adjacent to the micro-encapsulated nicotine layer that allows pressure to be applied to the micro-encapsulated nicotine layer while permitting permeation of released nicotine into a central channel for inhalation by a user. A mouthpiece may be disposed at an open end of the central channel in order to provide air resistance to simulate the inhalation effect of a cigarette.

The invention discloses a method for producing a controlled/slow release starch derivative with hypoglycemia response characteristics, and belongs to the technical field of the production of functional food additives. The method utilizes a conventional industrial natural polymer to obtain the controlled/slow release starch derivative with the hypoglycemia response characteristics through micro-encapsulation embedding technology. The method adopts emulsification/internal gelatination technology, takes commercialized starch with different sources as a core material, and takes a compound of canageenen or sodium alginate and chitosan as a wall material to obtain a starch derivative with a particle size of between 10 and 150mu m through micro-encapsulation embedding treatment. The content of temperature-resistant slowly digestible starch (SDS) is remarkably improved (more than or equal to 15 percent) relative to native starch in the starch derivative, and the change range of the content thereof does not exceed 3 percent after high-pressure cooking treatment. A glycemic index (GI) is lower than 55 percent. The starch derivative not only can be taken as a functional ingredient to be added to develop novel slowly digestible hypoglycemia food, but also can be taken as a carrier material of stabilization and targeted controlled/slow release of functional factors such as probiotics, active polypeptide, protein, grease, vitamin and the like.

The invention discloses a production method of lycopene microcapsule, providing a production method for realizing lycopene encapsulated emulsion by spray drying on the basis of the physical and chemical properties of lycopene. The method comprises the following steps: blending wall material solution, blending core material solution, homogenizing after the core material solution is mixed with the wall material solution, carrying out spray drying on emulsion, measuring lycopene microcapsule solubility, carrying out stability test and the like. Preferably, the preparation step of the lycopene microcapsule also comprises: an ultrasound assisted high-pressure homogenizing method is adopted to prepare the emulsion; and homogenized emulsion is performed with spray drying to obtain the lycopene microcapsule which has high solubility and favorable stability for light, heat and oxygen.

This invention provide novel compositions, methods and devices for sustained drug delivery. The microencapsulated sustained drug delivery compositions are deposited using oscillating needle apparatus oscillating at 10-12000 minutes per minutes. The injected compositions may undergo variety of physical chemical changes upon deposition. The physical and chemical changes enables improved drug encapsulation and sustained drug release. Also described are new methods to form polymer microparticles or polymer films/implants in situ inside the tissue. The invention also describes colored biodegradable microparticle based compositions wherein the compositions comprise drug encapsulated microparticles and coloring agent encapsulated microparticles mixed in any proportion. Medical applications of the compositions and methods described in this invention are also described.

The invention relates to a method and device for obtaining micro and nanometric particles in a controlled, reproducible manner. The aforementioned particles have a spherical shape and a very narrow, uniform size distribution. More specifically, the invention relates to a novel method of forming emulsions and to the application thereof in micro and nanoencapsulation techniques involving the extraction/evaporation of the solvent. In particular, the invention relates to the encapsulation of the fluorescent compounds and the subsequent application thereof.

Systems are provided for preventing post harvest fungal diseases of food systems, such as but not limited to fresh produce, such as but not limited to berries (e.g., blueberries). For example, various anti-fungal compounds can incorporated or encapsulated into cyclodextrins, such as but not limited to α, β and/or γ cyclodextrins. The encapsulated anti-fungal materials can be used alone (e.g., brought into proximity to the produce) or incorporated into film and/or packaging materials that are used in the packing and/or storing of produce. By way of a non-limiting example, the anti-fungal compounds can include volatile compounds such as but not limited to acetaldehyde, hexanal and 2E-hexenal. The cyclodextrins provide controlled release of the volatiles over a period of at least several days such that they prevent or inhibit fungal growth, including but not limited to several species of the Colletotrichum, Altermaria, Botrytis, Penicillium and/or Aspergillus genera.

A micro encapsulation material for use with storage unstable, therapeutic and nutritional agents which release the therapeutic and nutritional agents in predetermined locations in the gastro intestinal tract in which the microencapsulation material is formed by combining a food grade treated carbohydrate with a water soluble food grade protein. The therapeutic and nutritional agents form an oil phase which is emulsified with the water dispersed or dissolved encapsulant to encapsulate the therapeutic and nutritional agents. These agents may be oils or oil soluble or oil dispersible. The agents that may be encapsulated Include lipids (oils Including oxygen sensitive oils, fatty acids, triglycerides) and oil soluble and oil dispersible ingredients (including pharmaceuticals, probiotics, protein therapeutics and bioactives). The protein used may include any film forming water soluble protein or hydrolysed protein and includes milk proteins such as casein and its derivatives or whey proteins. The carbohydrate component may be those containing reducing sugar groups, oligosaccharides and starches (raw, modified, resistant, acetylated, proprionated and butyrated starches).

The present invention release to a suspend seed-coat agent which is prepared by following steps of encapsulizting triazole fungicides, and making the micro-capsule coved with active components into suspend seed-coat agent. The micro-capsule suspend seed-coat agent has slowly-releasing function and can prevent triazole fungicides seed coat from generating drug misadventures, specially, the drug misadventure under low temperature stress.

The invention relates to a method for preparing microencapsulation glucose oxidase, which belongs to the technical field of food processing. The invention aims at improving the quality of flour to researche a method for preparing new flour modifying agent, namely, the microencapsulation glucose oxidase, chitose-calcium alginate-glucose oxidase microcapsule which is obtained through the method is copolymer hydrogel which is obtained through double cross-linking, both amidogen and carboxyl group are fixed, and the whole system is a reticular formation. The method controls the catalytic speed of the microencapsulation glucose oxidase through adjusting the molecular weight and the degree of deacetylation of microcapsule exine chitose, thereby the method is beneficial for oxidation-linking of gluten protein and for increasing the quality of the flour and flour products, simultaneously, the glucose oxidase after microencapsulation avoids the contact between enzyme and the flour and improves storage and the stability, and the microencapsulation glucose oxidase is excellent flour modifying agent and accords with practical production and application. The process of the method is simple, safe and convenient, and accords with the requirements of environmental protection and utility.

Methods and compositions are provided for generating and applying long-lasting therapeutic nitric oxide (NO) gas from the reaction of water-soluble chemical reactants microencapsulated in polymer matrices. In some applications the microencapsulated reactants are introduced in an aqueous gel, and in other applications they are introduced to the area of therapy either directly or in a medical device such as a therapeutic pad or dressing. In some applications, the microencapsulated chemical precursors are maintained in close physical proximity to one another in a limited volume, and using a limited amount of solvent residing within that same volume to extract and process the chemical precursors to form NO.

The invention discloses a stable method for microencapsulating carotenoid. The method comprises 1) a step of completely dissolving a protecting colloid, sucrose or glucose, ascorbyl palmitate and EDTA into water, and adjusting pH to 10-11 to obtain a water phase A; 2) a step of completely dissolving carotenoid and an antioxidant into a solvent to obtain an oil phase B; 3) a step of adding the oil phase B into the water phase A under a condition of high-speed shearing and high-speed stirring; emulsifying the mixture to form an initial emulsion by stirring at a high speed; and heating and removing the solvent to obtain a microemulsion; and 4) a step of adding the obtained microemulsion into a spray drying system; and obtaining carotenoid particles or powder after spray drying. The carotenoid particles or powder prepared by the method have advantages of good dispersibility, high stability, good light permeability and small particle sizes.