The invention relates to a preparation method of electronic grade
hypoxanthine, which comprises the following steps: taking a
hypoxanthine crude product synthesized by an enzymic method as a
raw material, mixing the
hypoxanthine crude product with high-purity water at the temperature of 30-60 DEG C, adjusting the pH value to 7-9, adding 0.1%-2% of neutral or
alkaline protease to hydrolyze
protein to react for 0.5-3 hours, cooling to 5-30 DEG C, and performing suction
filtration to obtain the electronic grade hypoxanthine. Dissolving the wet product with an alkaline
aqueous solution at 50-80 DEG C, removing impurities with
activated carbon, performing hot
filtration, adjusting the pH value of the filtrate to 6.5-7.5 with electronic-grade acid, cooling to 5-30 DEG C, crystallizing, performing suction
filtration, washing the wet product with
purified water for 3-5 times, and
drying to obtain the product. Organic impurities,
metal ions and environmental particles are systematically removed, and finally the ultra-high-purity electronic-grade hypoxanthine is prepared. The
chemical purity of the prepared product is larger than or equal to 99.99%, the total
metal ion content is smaller than or equal to 100 ppb, the
moisture content is smaller than or equal to 0.1%, and the product has the advantages of being concentrated in
particle size distribution and uniform in
crystal form and completely meets the harsh requirements of
OLED and other high-end photoelectric devices for key organic materials.