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Preparation method and uses of carboxymethyl chitosan and sodium alginate blend microcapsule

A technology of carboxymethyl chitosan and sodium alginate, which is applied in the direction of microcapsule preparation, microsphere preparation, capsule delivery, etc., can solve the problem of low solubility, and achieve the effect of simple production process and good drug sustained release function

Inactive Publication Date: 2004-11-17
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the low solubility of chitosan in the in vivo environment (pH 7.4) limits its application as an absorption-enhancing carrier, such as an oronasal drug delivery system

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1: 5% carboxymethyl chitosan aqueous solution and 5% sodium alginate aqueous solution were mixed at a mass ratio of 1:1 to obtain a blend I. Then 0.5g of bovine serum albumin (BSA) was dissolved in 20mL of the above-mentioned blend solution I and mixed uniformly to obtain blend II, and then the blend II was dispersed in 40mL of liquid paraffin containing 1% emulsifier by volume. The emulsifier is composed of sorbitan monolaurate (Span-20) and polyoxyethylene sorbitan monolaurate (Tween-20) in a mass ratio of 1:1. Stir mechanically at high speed for 1.5 hours. Then CaCl 2 Coagulation solution (mass percentage is 5% CaCl 2 The aqueous solution and absolute ethanol are mixed in a volume ratio of 1:1) 60 mL is dropped into the above system within 0.5 hours, stirred for 2 hours, and finally 20 mL of isopropanol is added to solidify the microcapsules. Collect the microcapsules by filtration with a mass ratio of 5% CaCl 2 The microcapsules were washed with aqueous ...

Embodiment 2

[0008] Example 2: A 1% carboxymethyl chitosan aqueous solution and an 8% sodium alginate aqueous solution were mixed at a mass ratio of 1:3 to obtain a blend I. Then 0.1 g of bovine serum albumin (BSA) was dissolved in 40 mL of blend solution I and mixed uniformly to obtain blend II, and then the blend II was dispersed in 30 mL of liquid paraffin containing an emulsifier with a volume ratio of 0.5%. The emulsifier is composed of sorbitan monolaurate (Span-20) and polyoxyethylene sorbitan monolaurate (Tween-20) in a mass ratio of 1:1.5. Stir mechanically at high speed for 0.5 h. Then CaCl 2 Coagulation solution (mass percentage is 20% CaCl 2 Aqueous solution and absolute ethanol (mixed at a volume ratio of 1:1.5) 20 mL was added dropwise to the above system within 1 hour, stirred for 0.5 hour, and finally 10 mL of isopropanol was added to solidify the microcapsules. The microcapsules were collected by centrifugation, and then the mass ratio was 3% CaCl 2 The microcapsules a...

Embodiment 3

[0009] Example 3: 8% carboxymethyl chitosan aqueous solution and 1% sodium alginate aqueous solution were mixed at a mass ratio of 1:8 to obtain a blend I. Then 1 g of bovine serum albumin (BSA) was dissolved in 60 mL of the above-mentioned blend solution and mixed uniformly to obtain blend II, which was then dispersed in 60 mL of liquid paraffin containing 3% emulsifier by volume. The emulsifier is composed of sorbitan monolaurate (Span-20) and polyoxyethylene sorbitan monolaurate (Tween-20) in a mass ratio of 1:2. Stir mechanically for 2 hours. Then CaCl 2 Coagulation solution (mass percentage is 15% CaCl 2 Aqueous solution and absolute ethanol are mixed at a volume ratio of 1:2) 40 mL is added dropwise to the above system within 1.5 hours, stirred for 2 hours, and finally 30 mL of isopropanol is added to solidify the microcapsules. Collect the microcapsules by filtration, and then use the mass ratio of 4.5% CaCl 2 The microcapsules were washed with aqueous solution, dis...

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PUM

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Abstract

The invention discloses the preparation method and uses of carboxymethyl chitosan and sodium alginate blend microcapsule wherein the method comprises, using water as solvent to blend the water solution of carboxymethyl chitosan and sodium alginate into blending liquid I, dissolving the contained medicament bovine serum albumin into the blended solvent I and mixing homogeneously, obtaining blended liquid II, dispersing the blended liquid II into fluid wax containing emulsifying agent, dropping CaCl2 coagulated liquid into the system, charging 10-30 mL alcohol isopropylicum and hardening to obtain micro-encapsulation, which exhibits sensitive response function to the pH changes.

Description

technical field [0001] The invention relates to a preparation method and application of carboxymethyl chitosan and sodium alginate blended microcapsules. Background technique [0002] In recent years, controlled-release microspheres or microcapsules based on natural polymer materials have attracted increasing attention. Natural polymers have many advantages such as non-toxicity, degradability and biocompatibility, and are widely used as biomedical materials. They can mask the peculiar smell of drugs, improve drug stability and gastrointestinal absorption of drugs, and at the same time prolong the time after oral administration. drug release time. Chitosan has been widely used in the field of biomedical materials (Int. J. Pharm. 194, 1) due to its ability to stimulate immune activity, anticoagulation, antifungal and promote wound healing. In addition, chitosan has the ability to open the tight combination of epidermal cells and improve the penetration of macromolecular drug...

Claims

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Application Information

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IPC IPC(8): A61K9/48B01J13/02C08L5/00
Inventor 张俐娜彭湘红郭继
Owner WUHAN UNIV
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