94 results about "P-dioxanone" patented technology

Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymers or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.

The invention relates to a micro-needle patch containing a biodegradable polymer and a preparation method thereof. The biodegradable polymer is a poly(p-dioxanone) having the molecular weight of 1,000 to 1,000,000 Daltons or copolymer containing a p-dioxanone, such as copolymer of the p-dioxanone and a lactide, copolymer of the p-dioxanone and a glycolide, and the like. The micro-needle patch has no limitation on hydrophilic and hydrophobic property and molecular weight of the medicine, and does not cause any pain and stimulation, thereby improving the medicine bioavailability and the adaptability to the patient.

The invention is directed to a polishing pad for use in chemical-mechanical polishing comprising a biodegradable polymer. The biodegradable polymer comprises a repeat unit selected from the group consisting of glycolic acid, lactic acid, hydroxyalkanoic acids, hydroxybutyric acid, hydroxyvaleric acid, caprolactone, p-dioxanone, trimethylene carbonate, butylene succinate, butylene adipate, monosaccharides, dicarboxylic acid anhydrides, enantiomers thereof, and combinations thereof. The invention is further directed to methods of its use.

The invention is directed to a polishing pad for use in chemical-mechanical polishing comprising a biodegradable polymer. The biodegradable polymer comprises a repeat unit selected from the group consisting of glycolic acid, lactic acid, hydroxyalkanoic acids, hydroxybutyric acid, hydroxyvaleric acid, caprolactone, p-dioxanone, trimethylene carbonate, butylene succinate, butylene adipate, monosaccharides, dicarboxylic acid anhydrides, enantiomers thereof, and combinations thereof. The invention is further directed to methods of its use.

The present invention discloses one kind of hemostatic ligating clip of absorbable material for surgical abdominoscope operation. The hemostatic ligating clip includes one outer layer of polyglycolide and one inner layer of poly-p-dioxanone or p-dioxanone-lactide copolymer. The hemostatic ligating clip made of materials with high hydrophilicity and flexibility has high compatibility to skin and tissue, no injury to the tissue of human body and the degradation speed determined by the outer layer.

Novel semi-crystalline, epsilon-caprolactone-rich block copolymers of epsilon-caprolactone and p-dioxanone for long term absorbable medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, and other medical devices. Also disclosed are compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease.

The invention relates to a biodegradable medical polymer tubing and a preparation method thereof. The invention provides a biodegradable medical polymer tubing with adjustable diameter and controllable wall thickness and a preparation method thereof. The tubing is made from biodegradable medical polymer material, and has inner diameter of 0.5-20 mm and thickness of 0.05-10 mm; and the biodegradable medical polymer material is one of a homopolymer, a copolymer, a star-shaped polymer and a crosslinking polymer of trimethylene carbonate, p-dioxanone, lactide, caprolactone and glycollide.

The invention is directed to a polishing pad for use in chemical-mechanical polishing comprising a biodegradable polymer. The biodegradable polymer comprises a repeat unit selected from the group consisting of glycolic acid, lactic acid, hydroxyalkanoic acids, hydroxybutyric acid, hydroxyvaleric acid, caprolactone, p-dioxanone, trimethylene carbonate, butylene succinate, butylene adipate, monosaccharides, dicarboxylic acid anhydrides, enantiomers thereof, and combinations thereof. The invention is further directed to methods of its use.

The invention discloses a spinning solution, nuclear shell nanofiber as well as a preparation method and application thereof. A hydrophobic drug and polyvinyl alcohol (PVA) / polyethylene glycol-b-poly(p-dioxanone) (PEG-b-PPDO) are blended to obtain a spinning solution system, and the nuclear shell nanofiber is directly formed by utilizing a single-axis spinneret under a high-voltage electrostatic effect. The preparation method disclosed by the invention has the advantages of simple equipment, mild conditions, simple flow and low energy consumption, can be used for achieving the aims of high-efficiency embedding of the hydrophobic drug, controllable drug release speed and long sustained release time, and is very suitable for industrial production.

Novel semi-crystalline, epsilon-caprolactone-rich block copolymers of epsilon-caprolactone and p-dioxanone for long term absorbable medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, and other medical devices. Also disclosed are compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease.

The invention belongs to the field of biological suture lines, and particularly relates to a preparation method of a degradable suture line with barbs. The preparation method of the degradable sutureline with the barbs comprises the following steps of (1) preparing of a spinning solution, dissolving poly(p-dioxanone) into anhydrous dimethyl sulfoxide, and fully stirring, so as to obtain a poly(p-dioxanone) solution; treating for 2 to 8h by ultrasonic waves at the temperature of 60 to 80 DEG C, and filtering; removing air bubbles under the vacuum condition, so as to obtain the spinning solution; (2) preparing of a barb solution, mixing PCL (polycaprolactone) and PLGA (poly lactic-glycolic acid), dissolving into an organic solution, filtering, and removing air bubbles under the vacuum condition, so as to obtain the barb solution; (3) spinning; (4) preparing of the barbs: placing poly(p-dioxanone) wires into a barbed die, adding the barb solution, and shaping; (5) post-treatment. The preparation method has the advantages that the poly(p-dioxanone) wires are used for enhancing the tensile strength and elasticity; the exterior of each poly(p-dioxanone) wire is coated with one layer ofbarb solution; besides the function of enhancing the biological solubility and elasticity, the barbs are more uniform.

The present invention discloses polymers of poly(p-dioxanone having an inherent viscosity in the range of from 2.3 dL / g to about 8 dL / g, as determined at a concentration of 0.1 g / dL in hexafluoroisopropanol at 25 DEG C. This invention also describes improved surgical devices and filaments made from poly(p-dioxanone) with an inherent viscosity in the range of from 2.3 dL / g to about 8 dL / g, determined at a concentration of 0.1 g / dL in hexafluoroisopropanol at 25 DEG C. Additionally, disclosed are processes for manufacturing poly(p-dioxanone) with an inherent viscosity in the range of from 2.3 dL / g to about 8 dL / g, as determined at a concentration of 0.1 g / dL in hexafluoroisopropanol at 25 DEG C., as well as, processes for molding surgical articles and extruding surgical filaments from these polymers.

Novel absorbable polymeric blends made from components wherein at least one of the components is synthesized using mixtures of mono- and di-functional initiators are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is either poly(p-dioxanone) homopolymer, or a poly(p-dioxanone-co-glycolide) copolymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.

The invention relates to the technical field of contraceptive drugs, in particular to a biodegradation type long-acting subdermal contraceptive implant containing gestodene which uses the biodegradable polymer materials as the carrier for preparation and the preparation. The invention consists of the drug gestodene and the polymer biodegradable materials which are taken as a carrier (such as, trimethylene carbonate / p-Dioxanone copolymer (P(TMC-co-PDO))), a bar-shaped drug core is prepared by mixing the drug and the carrier, then the carrier materials are prepared into a drug delivery tube, then the drug core is arranged in the drug delivery tube, and the both ends are blocked by adhesives. The average daily drug delivery amount of the drug gestodene in the body is 10 to 30 micrograms. The implantation of one implant can be contraceptive for 1 to 2 years. The carrier materials can be degraded into small molecules after the release of the drug, the invention does not need to be taken out by the operation method, and the using cost is greatly reduced.

Novel absorbable polymeric blends made from components wherein at least one of the components is synthesized using mixtures of mono- and di-functional initiators are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is either poly(p-dioxanone) homopolymer, or a poly(p-dioxanone-co-glycolide) copolymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.

The invention relates to a medicinal gullet scaffold fiber capable of being absorbed by a human body and a manufacturing method thereof. A poly(p-dioxanone) (PPDO) fiber in accordance with the requirements is prepared by melt spinning. The method comprises the following preparation processes of: drying PPDO slices at the temperature of between 70 and 80 DEG C, and spinning the dried PPDO slices in a spinning beam by screw extrusion, wherein the spinning temperature is between 135 and 160 DEG C; extruding through a spinneret plate, and then cooling, curing and molding in a cooling tank, wherein the cooling solution contains 1,2-propylene glycol and absolute ethanol, the mass ratio of the 1,2-propylene glycol to the absolute ethanol is 3-5:1, and the temperature is between 35 and 40 DEG C; then cleaning the PPDO fiber by using the anhydrous ethanol, and controlling the temperature to be between 30 and 40 DEG C; performing hot plate drawing on the obtained fiber by 2 to 10 times, whereinthe drawing temperature is between 60 and 80 DEG C; and performing heat setting at the temperature of between 60 and 90 DEG C, and coiling. The fiber prepared by the method has good uniformity; the stability of the PPDO fiber during processing is ensured; and the fiber has no toxicity or stimulus, and has high mechanical support strength and good biodegradability, biocompatibility and machinability.

The invention relates to novel ceftriaxone sodium for injection and a preparation method thereof, and belongs to the technical field of medicines. The novel ceftriaxone sodium for injection consists of 1 part of ceftriaxone sodium, 0.30 to 0.33 part of ethyecellulose, 0.60 to 0.72 part of a stabilizer, 0.80 to 0.90 part of a surfactant, 70 to 80 parts of liquid paraffin and 0.27 to 0.30 part of ananti-sticking agent. The stabilizer p-dioxanone-lactide copolymer is a copolymer with a specific proportion, and plays an important role in preparation stability. According to the injection, the drugdelivery application twice every day becomes once administration through slow-release effect of a micro-capsule, the dosing interval is shortened, the injection is convenient to use, the biological availability is improved, the using amount of medicine is reduced, the curative effect is improved since the blood concentration is smooth, and the untoward effect is reduced. The novel ceftriaxone sodium for injection, provided by the invention, is simple in preparation technology and low in cost, is applicable for large-scale production, and is a product with very good market prospects.

The invention discloses an absorbable hemostatic ligating clip and a preparation method thereof. The absorbable hemostatic ligating clip is prepared from the following material components in parts by weight: 5 to 70 parts of polyglycolic acid composite particles and 30 to 95 parts of polyethylene glycol modified poly(p-dioxanone), wherein the polyglycolic acid composite particles consist of polyglycolic acid and cell factors according to the weight ratio of (40-45):1; the cell factors are blood coagulation factors or growth factors. According to the absorbable hemostatic ligating clip disclosed by the invention, the polyglycolic acid composite particles can be quickly decomposed in the early stage by adjusting the molecular weight and the use amount of polyglycolic acid, to assist damaged tissues in hemostasis or recovery; furthermore, the structure of the ligating clip is complete within two weeks to achieve an effective closing effect; after two weeks, the polyglycolic acid is gradually completely degraded, and then the cell factors are completely released, so that the ligating clip can be decomposed quickly within 2 to 4 weeks and fall off and is completely absorbed within 4 months; therefore, the clinical requirement is met, and the postoperative potential risk is reduced. The preparation method of the absorbable hemostatic ligating clip has simple technological conditions, the operation is easy, the requirement on equipment is low, and the absorbable hemostatic ligating clip and the preparation method thereof are suitable for large-scale industrial production.

The invention discloses a composite material of poly(p-dioxanone) / inorganic nano-fiber. The composite material is prepared by mixing a poly(p-dioxanone) matrix material and the inorganic nano-fiber based on the weight ratio of 0.5-10:100, wherein, the Young modulus of the composite material is 364-942MPa. The invention further discloses a preparation method of the composite material. In the invention, the inorganic nano-fiber contained in the composite material of the invention has high length-diameter ratio and weak aggregation force among the fibers, and the fiber is dispersed in the composite material in a nanometer size, thus significantly enhancing the melt strength of the material, improving the processability, and obviously increasing the strength of the composite material; and the preparation method is mature, simple, feasible and easily popularized.

The invention relates to a tear drainage reconstruction system that can be regularly degraded. The reconstruction system is made by adopting polydioxanone (PDO) that is a degradable polymeric biomaterial. The system comprises an upper lacrimal duct part, a lower lacrimal dust part, a main lacrimal duct, a concave dacryocyst part and a nasolacrimal duct part. The system has good flexibility, certain elasticity, extensibility, breaking strength and compression strength performance and is a lamella micro-porous tubular structure that integrates stable nasolacrimal duct supporting function, 'tears pump' function, dacryocyst drainage function, 'drug control-release' function, the function of accelerating the fade-away of chronic inflammation of a lacrimal duct and the repairing function of mucous membrane injury of the lacrimal duct together. The reconstruction system has the advantages that an implanting method is a simple and convenient, the fixation in the lacrimal duct is the stable and reliable and the iatrogenic lacrimal duct injury can not appear, the regular degradation can be realized without secondary take-out and the reconstruction system is suitable for various lacrimal duct obstruction diseases and has high curative ratio of the lacrimal duct obstruction, especially, the reconstruction system has the stable and reliable medium-to-long term effect. The tears drainage reconstruction system currently is the only perfect material for high-degree lacrimal duct reconstruction that combines the physiological drainage of the tears with the pathological mechanism of lacrimal injury repair.

The invention discloses a bioabsorbable antioxidant pulling beautifying line which comprises a suture needle and a line body; the line body comprises the following components: a substrate and an antioxidant; the substrate comprises at least one of poly(p-dioxanone), polycaprolactone and poly-L-lactic acid; the antioxidant comprises at least one of vitamin E, glutathione and rosemary extract. The bioabsorbable antioxidant pulling beautifying line has the characteristics of bio-absorbability and decomposition, has excellent antioxidation effect and ageing resistance and is capable of keeping proper toughness for a long time. The invention also discloses a line-burying method for removing under-eye puffiness. The effects of eliminating fat and removing under-eye puffiness can be achieved in the manner of adopting a specific line paving method for burying the pulling beautifying line in an orbital fat layer and an orbital diaphragmatic ligament, keeping the line body in full contact with adipose tissue, boosting fat metabolism absorption and enhancing the fastening and fixing effects of the orbital diaphragmatic ligament to the orbital fat. The line-burying method for removing under-eye puffiness requires no fat removal, is high in safety and is capable of achieving an excellent beautifying effect.

The invention discloses an electrostatic flocking adhesive and a preparation method thereof. The electrostatic flocking adhesive is prepared from ethyl acrylate, amyl acrylate, p-dioxanone, methyl tert butyl acrylate, ethyl ethyl acrylate, ethylacrylic acid-2-hydroxy butyl ester, ethyl methacrylate, dodecane phenol plyoxyethylene, sodium persulfate, sodium bicarbonate, nanometer titania and nano-zinc oxide. The invention further discloses the preparation method of the electrostatic flocking adhesive. The raw materials are subjected to emulsion copolymerization, and the electrostatic flocking adhesive is obtained. The electrostatic flocking adhesive prepared through cross-linking of all the raw materials has abrasion resistance and good hand feeling, and the electrostatic flocking adhesive has good antibacterial and bacteriostatic effects due to introduction of nanometer titania and nano-zinc oxide.

The invention relates to a hydroxyl telechelic polyester material based on piperazine block and a preparation method thereof. Piperazine serves as an assistant initiator, and stannous octoate serves as an initiator; at the temperature of 130-170 DEG C, an annular esters monomer (annular diester such as lactide, glycolide, epsilon-caprolactone, ixoxanone and the like or lactone) is initiated for fusion and ring-opening polymerization to obtain the hydroxyl telechelic polyester material. The main chain of the hydroxyl telechelic polyester material based on the piperazine block of the invention is inserted with piperazine micromolecule rigid rings, and the mechanical property of the material is correspondingly improved; piperzaine is a common drug intermediate, has a certain bioactivity and can fill up the deficiency of insufficient polyester material activity; meanwhile, the molar ratio of the piperaztine and the annular esters monomer is controlled to control the molecular weight of the polyester material, so that the hydroxyl telechelic polyester material is convenient to apply in different areas; in addition, the polyester has biodegradability and favourable biocompatibility, has important application value on the aspect of drug slow release carriers and tissue engineering biological materials and can serve as the ultra high molecular weight polymers or the prepolymers of the polyester biological materials.

The invention relates to POM (polyoxymethylene)-PLA (polylactic acid)-poly(p-dioxanone) ternary composite fibers and a preparation method thereof. The composite fibers comprise components including POM, PLA and poly(p-dioxanone), and the mass ratio of POM to PLA to poly(p-dioxanone) is (60-80):(12-30):(3-15). The preparation method comprises steps as follows: the three polymers are dried to reach constant weights, extruded by a screw, pass a pre-filter, a box body and an assembly, cooled in a spinning channel and wound, as-spun fibers are subjected to backend heat drawing and heat setting, and the composite fibers are obtained. The composite fibers have good mechanical performance, heat resistance and proper degradability and have a good application prospect.

The invention discloses a shape memory oviduct contraception device for realizing contraception. The device comprises a contraceptive suppository and a placer, wherein the contraceptive suppository is made of a macromolecular polymer material with shape memory effect; the shape memory polymer material is a polymer material of multistage polyurethane based on lactide and 1,4-p-dioxanone; the contraceptive suppository comprises a front section, a middle section and a tail section; the front section comprises a front part and a middle rear part, wherein the front part is of shuttle shape with smooth surface, and the middle rear part is a cylinder of which the surface is provided with a plurality of undulations; and the placer comprises an outer sleeve and an inner sheath. The device places the contraceptive suppository which maintains small diameter before placing in a perfect position inside the oviduct through a hysteroscope, and the contraceptive suppository is gradually deformed by the action of human body temperature and is restored to the initial shape of the contraceptive suppository, thereby completely blocking the oviduct to achieve the aim of contraception. The device has the advantages of convenience, high efficiency, safety, reliable contraception effect, non toxic or side effect and the like, and is applicable to popularization and application on a large scale.

The invention discloses a PBT material for automobile door handles, and a preparation method thereof. The PBT material comprises, by weight, 100 parts of PBT, 28-35 parts of ABS, 30-40 parts of EMA, 25-32 parts of a Ag<+> / SiO2 / TiO2 composite material, 6-12 parts of poly(p-dioxanone), 14-19 parts of sepiolite fibers, 1-2 parts of polyethylene glycol monooctadecyl ether, 9-11 parts of a compatilizer, 11-17 parts of a toughener, 8-15 parts of a filler, 2-7 parts of acoupling agent and 1-2 parts of an antioxidant. The PBT material prepared in the invention has the advantages of good mechanical properties, high rigidity and good antibacterial property, and is very suitable for being used as an automobile door handle material.

The invention discloses a micro-block-polymer used for a long-acting slow-releasing preparation and a preparation method thereof. The micro-block-polymer includes a glycolides block and a component Ablock according to weight ratio of 1-5:4-8, wherein the component A is lactide, caprolactone, trimethylene carbonate or p-dioxanone; the molecular weight of the micro-block-polymer is 5,000-500,000; in the glycolides block, the average sequence length of glycolides is 3-5. According to the invention, by adjusting the microstructures, such as length and distribution, of the sequence of the glycolides block, the degradation speed and dissolubility of the polymer can be adjusted, thus adjusting the medicine slow-releasing function of the long-acting slow-releasing preparation. In the application,the selected polymer is 3-5 in LGG, has regular structure and moderated degradation speed, so that burst release of the medicine is avoided. In addition, the block property of the polymer is moderated, so that the polymer has high solubility in most of organic solvents, so that the micro-block-polymer is suitable for majority of preparation processes for medicine preparations.

The invention relates to core-shell double-layer microspheres employing poly(p-dioxanone) as cores and a preparation method and application of the core-shell double-layer microspheres, belongs to the technical field of biological medicines, and provides core-shell double-layer microspheres employing poly(p-dioxanone) as cores and a preparation method of the core-shell double-layer microspheres. The method mainly comprises preparation of poly(p-dioxanone) microspheres and preparation of the double-layer microspheres with a core-shell structure by using the poly(p-dioxanone) microspheres. The method is simple in operation, good in repeatability and low in cost, and the preparation process is friendly to environment. The prepared microspheres are uniform and controllable are in particle size, safe, biodegradable, good in histocompatibility and slow in degradation; the degradation time can be regulated and controlled according to the type of a shell material and the adding ratios of core-shell materials. The microspheres can be widely applied to the fields of sustained release or controlled release drugs, and bioactive substance, cosmetic and soft tissue filling and repairing.

Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymers or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.