The invention relates to novel ceftriaxone sodium for injection and a preparation method thereof, and belongs to the technical field of medicines. The novel ceftriaxone sodium for injection consists of 1 part of ceftriaxone sodium, 0.30 to 0.33 part of ethyecellulose, 0.60 to 0.72 part of a stabilizer, 0.80 to 0.90 part of a surfactant, 70 to 80 parts of liquid paraffin and 0.27 to 0.30 part of ananti-sticking agent. The stabilizer p-dioxanone-lactide copolymer is a copolymer with a specific proportion, and plays an important role in preparation stability. According to the injection, the drugdelivery application twice every day becomes once administration through slow-release effect of a micro-capsule, the dosing interval is shortened, the injection is convenient to use, the biological availability is improved, the using amount of medicine is reduced, the curative effect is improved since the blood concentration is smooth, and the untoward effect is reduced. The novel ceftriaxone sodium for injection, provided by the invention, is simple in preparation technology and low in cost, is applicable for large-scale production, and is a product with very good market prospects.