Preparation method of degradable suture line with barbs

A technology of suture and silk thread, which is applied in the field of biological suture, can solve the problems of not being suitable for the development of suture technology, high manufacturing cost, and insufficient economy, and achieve the effects of enhancing biosolubility and elasticity, convenient operation, and uniform barbs

Inactive Publication Date: 2018-07-13
程光起
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current method of forming barbs on the existing sutures is to use physical cutting methods. This method has low cutting efficiency and has obvious shortcomings in economy. The existing methods have high manufacturing costs and are no longer suitable for the current suture technology. development of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Include the following steps:

[0020] (1) Preparation of spinning solution: Preparation of spinning solution: dissolve polydioxanone in anhydrous dimethyl sulfoxide, stir well to obtain polydioxanone solution, and heat at 60-80°C Ultrasonic treatment for 2 to 8 hours, after filtration, remove air bubbles under vacuum conditions to obtain spinning solution;

[0021] (2) Preparation of barb solution: mix PCL and PLGA, dissolve in organic solution, stir well to obtain a mixed solution, ultrasonically treat at 60-80°C for 2-8 hours, filter and remove air bubbles under vacuum condition, Obtain barbed solution; Wherein, the mass ratio of PCL and PLGA is: 1:2; The mass ratio of PCL and PLGA to the organic solution after mixing is: 3-5; The organic solution is dichloromethane;

[0022] (3) Spinning: The spinning solution is fed into the spinneret with a metering pump, and the spinning solution is squeezed into the coagulation bath and stretched while coagulating to obtain poly...

Embodiment 2

[0026] Include the following steps:

[0027] (1) Preparation of spinning solution: Preparation of spinning solution: dissolve polydioxanone in anhydrous dimethyl sulfoxide, stir well to obtain polydioxanone solution, and heat at 60-80°C Ultrasonic treatment for 2 to 8 hours, after filtration, remove air bubbles under vacuum conditions to obtain spinning solution;

[0028] (2) Preparation of barb solution: mix PCL and PLGA, dissolve in organic solution, stir well to obtain a mixed solution, ultrasonically treat at 60-80°C for 2-8 hours, filter and remove air bubbles under vacuum condition, Obtain barbed solution; Wherein, the mass ratio of PCL and PLGA is: 1:2; The mass ratio of PCL and PLGA after mixing with the organic solution is: 3-5; The organic solution is acetone;

[0029] (3) Spinning: The spinning solution is fed into the spinneret with a metering pump, and the spinning solution is squeezed into the coagulation bath and stretched while coagulating to obtain polydioxan...

Embodiment 3

[0033] Include the following steps:

[0034] (1) Preparation of spinning solution: Preparation of spinning solution: dissolve polydioxanone in anhydrous dimethyl sulfoxide, stir well to obtain polydioxanone solution, and heat at 60-80°C Ultrasonic treatment for 2 to 8 hours, after filtration, remove air bubbles under vacuum conditions to obtain spinning solution;

[0035] (2) Preparation of barb solution: mix PCL and PLGA, dissolve in organic solution, stir well to obtain a mixed solution, ultrasonically treat at 60-80°C for 2-8 hours, filter and remove air bubbles under vacuum condition, Obtain barbed solution; Wherein, the mass ratio of PCL and PLGA is: 1:2; The mass ratio of PCL and PLGA after mixing with the organic solution is: 3-5; The organic solution is dimethylformamide;

[0036] (3) Spinning: The spinning solution is fed into the spinneret with a metering pump, and the spinning solution is squeezed into the coagulation bath and stretched while coagulating to obtain ...

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Abstract

The invention belongs to the field of biological suture lines, and particularly relates to a preparation method of a degradable suture line with barbs. The preparation method of the degradable sutureline with the barbs comprises the following steps of (1) preparing of a spinning solution, dissolving poly(p-dioxanone) into anhydrous dimethyl sulfoxide, and fully stirring, so as to obtain a poly(p-dioxanone) solution; treating for 2 to 8h by ultrasonic waves at the temperature of 60 to 80 DEG C, and filtering; removing air bubbles under the vacuum condition, so as to obtain the spinning solution; (2) preparing of a barb solution, mixing PCL (polycaprolactone) and PLGA (poly lactic-glycolic acid), dissolving into an organic solution, filtering, and removing air bubbles under the vacuum condition, so as to obtain the barb solution; (3) spinning; (4) preparing of the barbs: placing poly(p-dioxanone) wires into a barbed die, adding the barb solution, and shaping; (5) post-treatment. The preparation method has the advantages that the poly(p-dioxanone) wires are used for enhancing the tensile strength and elasticity; the exterior of each poly(p-dioxanone) wire is coated with one layer ofbarb solution; besides the function of enhancing the biological solubility and elasticity, the barbs are more uniform.

Description

(1) Technical field [0001] The invention belongs to the field of biological sutures, in particular to a method for preparing degradable sutures with barbs. (2) Background technology [0002] Surgical suture is a sterile thread used for wound closure, tissue ligation and fixation. Non-biodegradable sutures cannot be absorbed by the body, and there are different degrees of tissue reactions. The sutured epidermis, especially the local skin, will leave scars; while biodegradable sutures are easily absorbed or excreted after degradation in body tissues, avoiding secondary The pain caused by the first operation reduces the chance of wound infection and the scar is small. Therefore, biodegradable medical sutures have attracted more and more attention. [0003] The current method of forming barbs on the existing sutures is to use physical cutting methods. This method has low cutting efficiency and has obvious shortcomings in economy. The existing methods have high manufacturing co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/14A61L17/10
CPCA61L17/10A61L17/145A61L2420/02
Inventor 程光起谢圣超李传圣程庭润刘畅
Owner 程光起
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