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Absorbable polymeric blend compositions based on copolymers prepared from mono- and di-functional polymerization initiators, processing methods, and medical devices therefrom

一种医疗装置、聚合物的技术，应用在机械设备、医药科学、外科固定钉等方向

Inactive Publication Date: 2016-10-12
ETHICON INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, due to the nature of commonly employed synthetic absorbent polyesters, this treatment often needs to be above their glass transition temperature, such that deformation is almost impossible to avoid

Method used

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  • Absorbable polymeric blend compositions based on copolymers prepared from mono- and di-functional polymerization initiators, processing methods, and medical devices therefrom
  • Absorbable polymeric blend compositions based on copolymers prepared from mono- and di-functional polymerization initiators, processing methods, and medical devices therefrom
  • Absorbable polymeric blend compositions based on copolymers prepared from mono- and di-functional polymerization initiators, processing methods, and medical devices therefrom

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0064]

[0065] Problem to be solved I :

[0066] Many absorbent resins have relatively low glass transition temperatures, resulting in low deflection temperatures unless the formed part crystallizes to a sufficient extent. From an economic standpoint [part / hour produced], the rate at which crystallinity develops to form a given part during the injection molding process is very important as the cycle time is increased to allow sufficient crystallization to occur in the mold. But perhaps more importantly from a performance standpoint, a long cycle time will result in a long residence time in the cylinder, leading to degradation of the resin. This degradation reduces the molecular weight of the resin, resulting in lower mechanical properties and possibly faster loss of mechanical properties over time after implantation.

[0067] Therefore, it is desired to increase the crystallization rate of absorbent resins to aid in the development of dimensional stability of molded par...

Embodiment 1

[0116] 85 / 15 poly(L(-)-lactide-co-glycolide): Synthesis of polymers with standard molecular weight distribution

[0117] Into a suitable conventional 15 gallon stainless steel oil-jacketed reactor equipped with an agitator was added 43.778 kg of L(-)-lactide and 6.222 kg of glycolide, along with 121.07 g of dodecanol and 9.02 mL of 0.33M stannous octoate Toluene solution. The reactor was closed and the purge cycle was started while stirring at a rotational speed of 12 RPM in an upward direction. The reactor was evacuated to a pressure of less than 200 mTorr, then nitrogen was introduced to achieve a pressure slightly in excess of one atmosphere. This cycle was repeated several times to ensure a dry atmosphere.

[0118] At the end of the last nitrogen introduction, the pressure was adjusted to slightly above one atmosphere. Heat the vessel at a rate of 180°C / hour until the oil temperature reaches about 130°C. The vessel was maintained at 130°C until the monomers were comp...

Embodiment 2

[0124] Poly(p-dioxanone): Synthesis of Standard Molecular Weight Polymers

[0125] Into a suitable conventional 65 gallon stainless steel oil-jacketed reactor equipped with an agitator was charged 164.2 kg of p-dioxanone monomer (PDO), along with 509 grams of dodecanol, 164 grams of D&C Violet No. 2 dye, and 100 grams of 0.33M stannous octoate in toluene. The reactor was closed and the purge cycle was started while stirring at a rotational speed of 12 RPM in an upward direction. The reactor was evacuated to a pressure of less than 500 mTorr, and then nitrogen gas was introduced. Repeat this cycle several times to ensure a dry atmosphere.

[0126] At the end of the last nitrogen introduction, the pressure was adjusted to slightly above one atmosphere. Heat the vessel at a rate of 180°C / hour until the oil temperature reaches about 100°C. The oil temperature was maintained at 100°C until the batch temperature reached 50°C, at which point the agitator rotation was changed to...

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Abstract

Novel absorbable polymeric blends made from components wherein at least one of the components is synthesized using mixtures of mono- and di-functional initiators are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is either poly(p-dioxanone) homopolymer, or a poly(p-dioxanone-co-glycolide) copolymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.

Description

technical field [0001] The technical field to which the present invention relates is absorbent polymers, in particular absorbent polymer blends made from absorbent polylactone copolymers using mono- and difunctional polymerization initiators prepared from blends of absorbent polymers that are useful in the manufacture of dimensionally stable, implantable medical devices and medical devices prepared from such blends. Background technique [0002] Absorbent polymers and medical devices made from such polymers are known in the art. Conventional absorbent polymers include polylactic acid, poly(p-dioxanone), polyglycolic acid, copolymers of lactide, glycolide, p-dioxanone, trimethylene carbonate, ε-caprolactone, various combinations thereof, and the like. Absorbent polymers are designed to have chemical properties such that the polymer breaks down in vivo by, for example, hydrolysis, and is metabolized or otherwise broken down from the patient's body and excreted. The advantag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L29/06A61L31/06A61L17/12C08G63/664C08L67/04A61B17/064
CPCA61L27/18A61L29/06A61L31/06A61L17/12C08L67/04A61B17/0642A61B2017/00004A61B2017/00889A61B2017/00893A61B17/064C08G63/664C08L2205/03C08L2205/025A61L31/041A61L31/148
Inventor S.安杰里D.D.贾米奥科维斯基B.M.凯利C.德弗里塞D.斯泰格
Owner ETHICON INC
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