33results about How to "Good bioabsorbability" patented technology

The invention relates to a gelatin-based micro-nanofiber membrane material, preparation method and utilization thereof and an electrostatic spinning machine used for processing the gelatin-based micro-nanofiber membrane material. The gelatin-based micro-nanofiber membrane material is composed of micro-nanofiber composed of 2-98 wt% of gelatin, 2-98 wt% of other biomolecule, 0-40 wt% of additive, 0-40 wt% of emulgator and 0-40 wt% of medicine. According to the arrangement, the conventional electrostatic spinning machine is modified, and a spiral-plate electrostatic spinning machine, a spring-type electrostatic spinning machine, a drum-type electrostatic spinning machine, a screw-type electrostatic spinning machine, a rotary-shaft electrostatic spinning machine or a gear-type electrostatic spinning machine used for processing the gelatin-based micro-nanofiber membrane material is achieved.

The invention discloses an absorbable endocranium healing patch and a preparation method thereof. The preparation method comprises: firstly processing a degradable high molecular material into a film impervious layer; at the same time weaving the degradable high molecular material into a netted sheet layer; then performing heat sealing processing on the film impervious layer and the netted sheet layer to prepare a double-layer composite material containing the impervious layer and the netted layer; and finally coating a bioactive component on the surface of the netted layer of the double-layer composite material to prepare the absorbable endocranium healing patch. The absorbable endocranium healing patch has excellent biodegradability, biocompatibility, biological absorbability, excellent flexibility, no repulsion reaction, and no toxicity, no carcinogenic and teratogenic effects, and can be completely absorbed after cambium is generated, and thus the absorbable endocranium healing patch can be more safely and more effectively applied to endocranium healing correlated medical operations.

This invention relates to an instrument for regenerating a living organism tissue or organ, characterized in that a support (A) formed from a biodegradable material or a bioabsorbable material includes a sponge-like fine matrix (B) formed from a biodegradable material or a bioabsorbable material and a linear guide channel (C) for a living organism tissue or organ.

A coenzyme Q10-containing composition comprising a coenzyme Q10 and a hydrophilic fatty acid ester of a polyhydric alcohol; a coenzyme Q10-containing composition comprising a coenzyme Q10, a lipophilic fatty acid ester of a polyhydric alcohol and a hydrophilic fatty acid ester of a polyhydric alcohol; and a food or beverage comprising the coenzyme Q10-containing composition as defined above.

The invention relates to a fiber compact double-layered composite film, which consists of two layers including a smooth compact film and a nano fiber film. The two films are combined tightly and cannot be separated. A preparation method of the fiber compact double-layered composite film includes mixing and dissolving polylactic-co-glycolic acid and polylactide-b-polyethylene glycol into N, N-dimethylformamide or acetone or mixture of the N, N- dimethylformamide and the acetone so as to obtain uniform polymer solution; then knifing the polymer solution on a roller or realizing electrostatic spinning on the roller and then drying the roller after heating the roller so as to obtain the compact film layer; and finally realizing electrostatic spinning on the compact film to obtain a fiber film layer, and accordingly obtaining the fiber compact double-layered composite film. The fiber compact double-layered composite film has excellent biocompatibility, biodegradation and biological absorption, and simultaneously has the advantages of light weight and softness. Besides, mechanical property and degradation period of the fiber compact double-layered composite film can be flexibly adjusted according to service needs.

The invention relates to a biodegradable graphene oxide biocomposite fibrous membrane and a preparation method and uses thereof. The composite fibrous membrane comprises biodegradable graphene oxide biocomposite fibers, each fiber has an outer layer consisting of graphene oxide-biodegradable polymer nanofibers and an inner layer consisting of sodium alginate / polyvinyl alcohol nanocomposite fibers. The biodegradable graphene oxide biocomposite fibrous membrane of the invention has the advantages of good biocompatibility, biodegradability, swellability, bacteriostasis and good mechanical properties and chemical stability.

An object of the present invention is to provide an internal composition capable of exerting various physiological functions such as a brain-function improving function. That is, the present invention provides an internal composition including docosahexaenoic acid and capsanthin, or docosahexaenoic acid, capsanthin, lutein, and zeaxanthin as active ingredients.

A low-molecular-weight hyaluronic acid and / or its salt has an average molecular weight of 5000 to 20,000, and has a molecular weight distribution in which the proportion of components having a molecular weight of 10,000 or less is 40 wt % or more and the proportion of components having a molecular weight of 50,000 or more is 5 wt % or less.

Provided is a composition for hot melt extrusion including a drug and hypromellose acetate succinate (HPMCAS) having a hydroxypropoxy molar substitution of 0.40 or more and a mole ratio of an acetyl group to a succinyl group of less than 1.6. Further, provided is a method for producing a hot melt extrudate including the step of hot melt-extruding a composition for hot melt extrusion including a drug and hypromellose acetate succinate having a molar hydroxypropoxy substitution of 0.40 or more and a mole ratio of an acetyl group to a succinyl group of less than 1.6, at a hot melt temperature of not lower than a melting temperature of the hypromellose acetate succinate or of not lower than a temperature at which both the hypromellose acetate succinate and the drug are melted.

The present invention provides a method for preparing a composition comprising porous ceramic, comprising the following steps: (a) synthesizing poly(N-isopropylacrylamide-co-methacrylic acid) (p(NIPAAM-MAA)) or similar thermo-response compound thereof; (b)mixing a dispersant with hydroxyapatite or calcium phosphate salt; (c) mixing the p(NIPAAM-MAA) of the step (a) or similar thermo-response compound thereof with water to obtain a hydrogel solution; (d) mixing the hydrogel solution of the step (c) and product of the step (b) to produce a mixture; (e) adding macromolecular particles to the mixture of the step (d) and stirring to produce a slurry; (f) filling the slurry of the step (e) into a template slot; and disposing the template slot filling with the slurry of the step (f) on a crucible, then proceeding high temperature sinter in a furnace to form the composition comprising porous ceramic.

The present invention provides a method for preparing a composition comprising porous ceramic, comprising the following steps: (a) synthesizing poly(N-isopropylacrylamide-co-methacrylic acid) (p(NIPAAM-MAA)) or similar thermo-response compound thereof; (b) mixing a dispersant with hydroxyapatite or calcium phosphate salt; (c) mixing the p(NIPAAM-MAA) of the step (a) or similar thermo-response compound thereof with water to obtain a hydrogel solution; (d) mixing the hydrogel solution of the step (c) and product of the step (b) to produce a mixture; (e) adding macromolecular particles to the mixture of the step (d) and stirring to produce a slurry; (f) filling the slurry of the step (e) into a template slot; and disposing the template slot filling with the slurry of the step (f) on a crucible, then proceeding high temperature sinter in a furnace to form the composition comprising porous ceramic.

A low-molecular-weight hyaluronic acid and / or its salt has an average molecular weight of 5000 to 20,000, and has a molecular weight distribution in which the proportion of components having a molecular weight of 10,000 or less is 40 wt % or more and the proportion of components having a molecular weight of 50,000 or more is 5 wt % or less.

The invention belongs to the technical field of biomaterials, and particularly relates to a preparation method and an application of a high-biocompatibility biodegradable bone filling material. The bone filling material is composed of polyurethane urea having phosphorylcholine at the end of a flexible side chain, and polyurethane urea is prepared from a single-ended dihydroxy polyethylene glycol phosphorylcholine compound, double-ended hydroxypolydioxanone and L-lysine diisocyanate-1,4-dibutyl diamine-L-lysine diisocyanate. The phosphorylcholine group located at the end of the flexible polyethylene glycol side chain is easily enriched on the surface of the material in order to greatly improve the hydrophilicity of the material, hinder the deposition of platelets and proteins and avoid theformation of thrombus, so the material has high biocompatibility, solves the problems of low biocompatibility and poor mechanical performances of polyurethane with the side chain simply being polyethylene glycol or phosphorylcholine, especially used a long-term implant material, in the biomedical field, and has widened applications in fields of tissue engineering, drug controlled release, gene therapy and cosmetics.

The present invention relates to a composition including S-adenosyl-L-methionine; and at least one kind of additive selected from carboxymethylcellulose, hydroxypropylcellulose, soybean polysaccharide, casein sodium, and zein, in which S-adenosyl-L-methionine is extracted from S-adenosyl-L-methionine-containing cells obtained by culturing a microorganism having an ability to produce SAMe, and the content of the additive in the composition falls within the range of 0.05 to 15 times by mass of S-adenosyl-L-methionine in the composition. The present invention provides a composition containing a high concentration of S-adenosyl-L-methionine, which is useful as a water-soluble physiologically active substance, and being excellent in storage stability and bioabsorbability. The present invention also relates to a molded article formed by using the composition and a method of producing the composition.

A novel A1-B-A2 polymer having a number average molecular weight of 10000 to 100000 is provided that has excellent bioabsorbability so as to disappear in a predetermined period of time even when embedded in a large amount in the body, has good kinetic properties, and is useful for preparing tissue anti-adhesion films. This polymer is composed of segments A1 and A2 each having at least either of modified and unmodified amino acid groups, and segment B composed of PEG having a number average molecular weight of 8000 to 50000. The polymer contains both the modified and unmodified amino acid groups, the content of the modified amino acids is 20 to 85 mol % of all the amino acids in the polymer, and segment A1 is bonded to one end of segment B and segment A2 is bonded to the other end of segment B.

The invention relates to core-shell double-layer microspheres employing poly(p-dioxanone) as cores and a preparation method and application of the core-shell double-layer microspheres, belongs to the technical field of biological medicines, and provides core-shell double-layer microspheres employing poly(p-dioxanone) as cores and a preparation method of the core-shell double-layer microspheres. The method mainly comprises preparation of poly(p-dioxanone) microspheres and preparation of the double-layer microspheres with a core-shell structure by using the poly(p-dioxanone) microspheres. The method is simple in operation, good in repeatability and low in cost, and the preparation process is friendly to environment. The prepared microspheres are uniform and controllable are in particle size, safe, biodegradable, good in histocompatibility and slow in degradation; the degradation time can be regulated and controlled according to the type of a shell material and the adding ratios of core-shell materials. The microspheres can be widely applied to the fields of sustained release or controlled release drugs, and bioactive substance, cosmetic and soft tissue filling and repairing.

The present invention relates to a mineral composition, characterized in that the mineral composition comprises 100 parts by weight of a metal salt having a solubility product in water at 25° C. of 1.0×10−7 or less and 0.5 to 50 parts by weight of an emulsifier having an HLB of 6 to 10, wherein the metal salt comprises fine particles having an average particle size of 0.05 to 1 μm.

A novel A1-B-A2 polymer having a number average molecular weight of 10000 to 100000 is provided that has excellent bioabsorbability so as to disappear in a predetermined period of time even when embedded in a large amount in the body, has good kinetic properties, and is useful for preparing tissue anti-adhesion films. This polymer is composed of segments A1 and A2 each having at least either of modified and unmodified amino acid groups, and segment B composed of PEG having a number average molecular weight of 8000 to 50000. The polymer contains both the modified and unmodified amino acid groups, the content of the modified amino acids is 20 to 85 mol % of all the amino acids in the polymer, and segment A1 is bonded to one end of segment B and segment A2 is bonded to the other end of segment B.

The invention relates to a preparation method of a cortex phellodendri composite biological glass tissue repair material, and belongs to the field of biomedical materials, wherein the preparation method comprises: preparing a cortex phellodendri extraction liquid, preparing a polylactic acid solution, preparing a biological glass solution, and carrying out electrospinning to obtain the repair material. According to the present invention, the cortex phellodendri has the antibacterial effect, the polylactic acid can improve the mechanical property of the material, and the biological glass can improve the pharmaceutical property of the material; and the prepared tissue repair material has advantages of good mechanical property, good tissue repair property, and good drug adhesion property.

An antiadhesive material that is excellent in biocompatibility and bioabsorbability, as well as excellent strength in suturing and bonding, is provided. A reinforcing material 12 made of a biodegradable polymer is placed in a gelatin solution so that the reinforcing material 12 is impregnated with the solution, and the gelatin is caused to gelate and dried. By so doing, an antiadhesive material in which a gelatin film 11 and the reinforcing material12 are integrated is obtained. The reinforcing material 12 preferably is arranged in a portion of the gelatin film 11 to be subjected to suturing, and preferably is arranged along a periphery of the gelatin film 11. The gelatin film 11 preferably is a cross-linked gelatin film, and the reinforcing material 12 preferably is a nonwoven fabric.

The invention relates to a gelatin-based micro-nano fiber membrane material prepared by needle-free electrospinning, a preparation method and application thereof, and an electrospinning machine for preparing the gelatin-based micro-nano fiber membrane material. The gelatin-based micro-nanofiber membrane material prepared by needle-free electrospinning in the present invention is composed of gelatin, other biomolecules, additives, emulsifiers and medicines; gelatin The content of the compound is 2-98wt%, the content of other biomolecules is 2-98wt%, the content of the additive is 0-40wt%, the content of the emulsifier is 0-40wt%, and the content of the drug is 0-40wt%. The present invention improves the existing electrospinning machine to obtain a screw-type electrospinning machine, a spring-type electrospinning machine, a drum-type electrospinning machine, a screw-type electrospinning machine, and a screw-type electrospinning machine for preparing gelatin-based micro-nano fiber membrane materials. Spinning machine, shaft electrospinning machine or gear electrospinning machine.

The present disclosure provides a micron fish oil composition and a method for preparing the micron fish oil composition. The method includes mixing a composite plant colloid with a fish oil and subjecting to an emulsification treatment to obtain an emulsion; and homogenizing the emulsion at a pressure of 300 bar to 350 bar to obtain the micron fish oil composition. The present disclosure also provides a method for enhancing bioabsorbability and bioavailability in a subject, including administering to the subject in need thereof a food product including an effective amount of the micron fish oil composition.

Provided is a tyrosine formulation excellent in bioabsorbability of tyrosine when ingested orally. An oral formulation with improved bioabsorbability of tyrosine, including glycyltyrosine or a salt thereof or a solvate thereof.

A coenzyme Q10-containing composition comprising a coenzyme Q10 and a hydrophilic fatty acid ester of a polyhydric alcohol; a coenzyme Q10-containing composition comprising a coenzyme Q10, a lipophilic fatty acid ester of a polyhydric alcohol and a hydrophilic fatty acid ester of a polyhydric alcohol; and a food or beverage comprising the coenzyme Q10-containing composition as defined above.

The invention discloses a photosensitive bioabsorbable polymer with an in-situ cell adhesion resistance function and a preparation method of the photosensitive bioabsorbable polymer, and belongs to the technical field of biomedical polymer materials and photocuring. The photosensitive bioabsorbable polymer is prepared from the following raw materials: a multi-arm lactic acid oligomer with double bonds, vinyl pyrrolidone and a photoinitiator. The preparation method comprises the following steps: adding NVP with an in-situ anti-cell-adhesion function into a multi-arm lactic acid oligomer liquid with a double-bond structure in situ, and carrying out cross-linking curing molding on the components by virtue of an ultraviolet curing technology, so as to prepare the photosensitive bioabsorbable polymer with the in-situ anti-cell-adhesion function. The problems that in a traditional alteration technology, a drug sustained-release anti-cell hyperplasia coating is prone to stripping and drug burst release is caused can be effectively solved, and the preparation method has the advantages of being safe in preparation process, low in cost, free of solvent, high in curing speed and the like.

The invention discloses a method for manufacturing a micro-pipeline stent with a nano structure on the inner wall. The micro-pipeline stent with a nano structure on the inner wall is manufactured by the steps of manufacturing a template, preparing a macromolecular solution, casting, stripping, ordering for bonding, and the like through combining a thermal fluid reflux and plasma induction coupling technology; and the micro-pipeline stent with a nano structure on the inner wall has the advantages of favorable biocompatibility, biodegradability and biological absorbability and novel and unique structure, is beneficial to the growth and spreading of cells, can improve the function of the stent in a living body and maintain the normal metabolism of the cells and has wide application prospect in the fields of transportation of nutrient substances, exchange of metabolic products, a culture base plate of active substances, a stent material of sealed space, tissue engineering stent materials, and the like.

The present invention relates to a mineral composition, characterized in that the mineral composition comprises 100 parts by weight of a metal salt having a solubility product in water at 25° C. of 1.0×10−7 or less and 0.5 to 50 parts by weight of an emulsifier having an HLB of 6 to 10, wherein the metal salt comprises fine particles having an average particle size of 0.05 to 1 μm.

The invention discloses a method for preparing a purslane composite bioglass traditional Chinese medicine repair material and belongs to the field of biological medicine materials. The method comprises the following steps: preparing a purslane extracting solution, preparing a polyphosphazene solution, preparing a bioglass solution, and performing electrostatic spinning, thereby obtaining the repair material. The purslane contains unique bioactive components and is capable of enhancing the activity of human epithelial cells; the polyphosphazene has excellent biodegradability, bioabsorbability and biocompatibility and is capable of improving mechanical property of the material, and the bioglass is capable of improving the medicinal properties of the material. The repair material prepared by the invention has excellent mechanical property, tissue repair performance and drug adhesiveness.

The invention belongs to the technical field of biomaterials, and particularly relates to a preparation method and an application of a high-biocompatibility biodegradable bone filling material. The bone filling material is composed of polyurethane urea having phosphorylcholine at the end of a flexible side chain, and polyurethane urea is prepared from a single-ended dihydroxy polyethylene glycol phosphorylcholine compound, double-ended hydroxypolydioxanone and L-lysine diisocyanate-1,4-dibutyl diamine-L-lysine diisocyanate. The phosphorylcholine group located at the end of the flexible polyethylene glycol side chain is easily enriched on the surface of the material in order to greatly improve the hydrophilicity of the material, hinder the deposition of platelets and proteins and avoid theformation of thrombus, so the material has high biocompatibility, solves the problems of low biocompatibility and poor mechanical performances of polyurethane with the side chain simply being polyethylene glycol or phosphorylcholine, especially used a long-term implant material, in the biomedical field, and has widened applications in fields of tissue engineering, drug controlled release, gene therapy and cosmetics.

The invention relates to core-shell double-layer microspheres employing poly(p-dioxanone) as cores and a preparation method and application of the core-shell double-layer microspheres, belongs to the technical field of biological medicines, and provides core-shell double-layer microspheres employing poly(p-dioxanone) as cores and a preparation method of the core-shell double-layer microspheres. The method mainly comprises preparation of poly(p-dioxanone) microspheres and preparation of the double-layer microspheres with a core-shell structure by using the poly(p-dioxanone) microspheres. The method is simple in operation, good in repeatability and low in cost, and the preparation process is friendly to environment. The prepared microspheres are uniform and controllable are in particle size, safe, biodegradable, good in histocompatibility and slow in degradation; the degradation time can be regulated and controlled according to the type of a shell material and the adding ratios of core-shell materials. The microspheres can be widely applied to the fields of sustained release or controlled release drugs, and bioactive substance, cosmetic and soft tissue filling and repairing.