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Gelatin-based micro-nanofiber membrane material and its preparation method and use

A micro-nano fiber, gelatin-based technology, applied in fiber treatment, fiber chemical characteristics, rayon manufacturing, etc., can solve the problems of difficult to remove organic solvents, easy water absorption, poor moisture resistance, etc.

Active Publication Date: 2017-07-14
杭州中科润德生物技术发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the first aspect, the gelatin fibers prepared by the prior art generally have thicker diameters (generally above the micron level), uneven distribution, poor moisture resistance, easy deformation, easy breaking, and easy water absorption; the second aspect, pure gelatin The aqueous solution is in a colloidal state at room temperature, and it is difficult to spin micro-nano fibers through a syringe-type electrospinning device, and gelatin is not easily soluble in organic solvents
At present, several limited literature reports focus on some fluorine-containing organic solvents, such as trifluoroethanol, hexafluoroisopropanol, etc. , solvent recovery difficulties and other shortcomings (Journal of Functional Polymers, 2008, 21 (3), 312-316; Journal of Biomedical Materials Research Part A, 2009, 90 (3), 671-679); the third aspect, the current electrospinning The silk machine mostly adopts the method of needle spinning, the needle is easy to block and the spinning efficiency is low
These all limit the wide application of gelatin-based micro-nanofibrous membranes.

Method used

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  • Gelatin-based micro-nanofiber membrane material and its preparation method and use
  • Gelatin-based micro-nanofiber membrane material and its preparation method and use
  • Gelatin-based micro-nanofiber membrane material and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Such as figure 1 As shown, the screw-type electrospinning machine used to prepare gelatin-based micro-nanofiber membrane materials, it is installed in the cabinet 17 made of acrylic glass with more than two screws made of polytetrafluoroethylene materials. The liquid tank 4 of the sheet type electrospinning machine, and each of the liquid tanks is equipped with a liquid supply pipe 15 made of pp plastic material; and the spiral sheet type electrospinning machine in the adjacent liquid tank The screw spinning head (composed of multiple screws) is placed in a liquid tank in a longitudinal direction of the screw spinning head, and a horizontal direction of the screw spinning head is placed in a liquid tank in an alternate manner (such as Figure 7 shown).

[0079] The screw spinning head of the screw type electrospinning machine is installed on the rotating shaft, and is connected with a transmission part made of polytetrafluoroethylene by the rotating shaft, and the tran...

Embodiment 2

[0093] Such as figure 2 As shown, the structure of the screw electrospinning machine used to prepare the gelatin-based micro-nanofiber membrane material is basically the same as that of the screw electrospinning machine in Example 1, except that the spinning head is replaced, and the screw is spun The head is replaced with a screw spinning head.

[0094] The gelatin-based microfibrous membrane material was prepared using the above-mentioned screw electrospinning machine.

[0095] (1) Adopt the gelatin that molecular weight is 250,000, gelatin is dissolved in 1wt% acetic acid solution, add chitosan after stirring to dissolving completely, continue to stir for 48 hours to obtain spinning solution after forming uniform fluid solution, the spinning solution The content of gelatin in the solute is 98wt%, and the content of chitosan is 2wt%; Then the spinning solution is loaded in 4 adjacent liquid tanks of the electrospinning machine respectively, and the loaded in the adjacent l...

Embodiment 3

[0103] Such as image 3 As shown, the structure of the drum-type electrospinning machine used to prepare the gelatin-based nanofiber membrane material is basically the same as that of the screw-type electrostatic spinning machine in Example 1, except that the spinning head is replaced, and the screw-type spinning head Change to drum spinning head.

[0104] The gelatin-based nanofibrous membrane material was prepared using the drum-type electrospinning machine described above.

[0105] (1) Adopting gelatin with a molecular weight of 10,000, dissolving the gelatin in 5wt% ethanol solution, stirring until completely dissolved, to obtain a gelatin solution; dissolving chitosan in 1wt% acetic acid solution, stirring until completely dissolving, obtaining a shell polysaccharide solution; then add calcium alginate to the gelatin solution, and continue to stir for 12 hours to obtain a spinning solution containing gelatin after forming a uniform fluid solution; wherein the content of ...

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Abstract

The invention relates to a gelatin-based micro-nano fiber membrane material prepared by needle-free electrospinning, a preparation method and application thereof, and an electrospinning machine for preparing the gelatin-based micro-nano fiber membrane material. The gelatin-based micro-nanofiber membrane material prepared by needle-free electrospinning in the present invention is composed of gelatin, other biomolecules, additives, emulsifiers and medicines; gelatin The content of the compound is 2-98wt%, the content of other biomolecules is 2-98wt%, the content of the additive is 0-40wt%, the content of the emulsifier is 0-40wt%, and the content of the drug is 0-40wt%. The present invention improves the existing electrospinning machine to obtain a screw-type electrospinning machine, a spring-type electrospinning machine, a drum-type electrospinning machine, a screw-type electrospinning machine, and a screw-type electrospinning machine for preparing gelatin-based micro-nano fiber membrane materials. Spinning machine, shaft electrospinning machine or gear electrospinning machine.

Description

technical field [0001] The invention belongs to the field of non-woven fabrics in biological materials, and particularly relates to a gelatin-based micro-nano fiber membrane material prepared by needle-free electrospinning and its application, a preparation method of the gelatin-based micro-nano fiber membrane material, and a method for preparing gelatin-based micro-nano fiber membrane material. Electrospinning machine for nanofibrous membrane materials. Background technique [0002] Under the action of a high-voltage electric field, the charged polymer solution or melt will form a cone, which is the so-called "Taylor cone"; continue to increase the electric field strength, and the polymer solution or melt will form a cone from the "Taylor cone". squirt. The jet stream oscillates under the action of a high-voltage electric field, which produces irregular spiral motion with a high frequency, resulting in the rapid thinning of the jet stream, rapid volatilization of the solve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/4382D04H1/728D01F1/10D01D5/00A61L15/32A61L15/44A61L27/22A61L27/60A61L27/54A61K47/42
Inventor 郭燕川卢伟鹏徐海涛
Owner 杭州中科润德生物技术发展有限公司
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