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Gelatin-based micro-nanofiber membrane material, preparation method and utilization thereof

A technology of micro-nano fibers and nano-fiber membranes, applied in fiber processing, fiber chemical characteristics, rayon manufacturing, etc., can solve problems such as easy water absorption, poor moisture resistance, and easy deformation.

Active Publication Date: 2015-04-29
杭州中科润德生物技术发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the first aspect, the gelatin fibers prepared by the prior art generally have a relatively thick diameter (generally above the micron level), uneven distribution, poor moisture resistance, easy deformation, easy breaking, and easy water absorption; in the second aspect, pure gelatin The aqueous solution is in a colloidal state at room temperature, and it is difficult to spin micro-nano fibers through a syringe-type electrospinning device, and gelatin is not easily soluble in organic solvents
At present, several limited literature reports focus on some fluorine-containing organic solvents, such as trifluoroethanol, hexafluoroisopropanol, etc. , solvent recovery difficulties and other shortcomings (Journal of Functional Polymers, 2008, 21 (3), 312-316; Journal of Biomedical Materials Research Part A, 2009, 90 (3), 671-679); the third aspect, the current Electrospinning machines mostly adopt the method of needle spinning, the needle is easy to block and the spinning efficiency is low
These all limit the wide application of gelatin-based micro-nanofibrous membranes.

Method used

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  • Gelatin-based micro-nanofiber membrane material, preparation method and utilization thereof
  • Gelatin-based micro-nanofiber membrane material, preparation method and utilization thereof
  • Gelatin-based micro-nanofiber membrane material, preparation method and utilization thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Such as figure 1 As shown, the screw-type electrospinning machine used to prepare gelatin-based micro-nanofiber membrane materials, it is installed in the cabinet 17 made of acrylic glass with more than two screws made of polytetrafluoroethylene materials. The liquid tank 4 of the sheet type electrospinning machine, and each of the liquid tanks is equipped with a liquid supply pipe 15 made of pp plastic material; and the spiral sheet type electrospinning machine in the adjacent liquid tank The screw spinning head (composed of multiple screws) is placed in a liquid tank in a longitudinal direction of the screw spinning head, and a horizontal direction of the screw spinning head is placed in a liquid tank (such as Figure 7 shown).

[0079] The screw spinning head of the screw type electrostatic spinning machine is installed on the rotating shaft, and the rotating shaft is connected with the transmission part made of polytetrafluoroethylene, and the transmission part is ...

Embodiment 2

[0093] Such as figure 2 As shown, the structure of the screw electrospinning machine used to prepare the gelatin-based micro-nanofiber membrane material is basically the same as that of the screw electrospinning machine in Example 1, except that the spinning head is replaced, and the screw is spun The head is replaced with a screw spinning head.

[0094] The gelatin-based microfibrous membrane material was prepared using the above-mentioned screw electrospinning machine.

[0095] (1) Use gelatin with a molecular weight of 250,000, dissolve the gelatin in 1wt% acetic acid solution, add chitosan after stirring until completely dissolved, and continue stirring for 48 hours to form a uniform fluid solution to obtain a spinning solution. The content of gelatin is 98wt%, and the content of chitosan is 2wt%; Then the spinning solution is respectively loaded in 4 adjacent liquid tanks of the electrospinning machine, and the spinning solution loaded in the adjacent liquid tanks The ...

Embodiment 3

[0103] Such as image 3 As shown, the structure of the drum-type electrospinning machine used to prepare the gelatin-based nanofiber membrane material is basically the same as that of the screw-type electrostatic spinning machine in Example 1, except that the spinning head is replaced, and the screw-type spinning head Change to drum spinning head.

[0104] The gelatin-based nanofibrous membrane material was prepared using the drum-type electrospinning machine described above.

[0105] (1) Use gelatin with a molecular weight of 10,000, dissolve the gelatin in 5wt% ethanol solution, stir until completely dissolved to obtain a gelatin solution; dissolve chitosan in 1wt% acetic acid solution, and stir until completely dissolved to obtain a shell polysaccharide solution; then add calcium alginate to the gelatin solution, and continue stirring for 12 hours to form a uniform fluid solution to obtain a spinning solution containing gelatin; wherein the gelatin content in the spinning ...

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Abstract

The invention relates to a gelatin-based micro-nanofiber membrane material, preparation method and utilization thereof and an electrostatic spinning machine used for processing the gelatin-based micro-nanofiber membrane material. The gelatin-based micro-nanofiber membrane material is composed of micro-nanofiber composed of 2-98 wt% of gelatin, 2-98 wt% of other biomolecule, 0-40 wt% of additive, 0-40 wt% of emulgator and 0-40 wt% of medicine. According to the arrangement, the conventional electrostatic spinning machine is modified, and a spiral-plate electrostatic spinning machine, a spring-type electrostatic spinning machine, a drum-type electrostatic spinning machine, a screw-type electrostatic spinning machine, a rotary-shaft electrostatic spinning machine or a gear-type electrostatic spinning machine used for processing the gelatin-based micro-nanofiber membrane material is achieved.

Description

technical field [0001] The invention belongs to the field of non-woven fabrics in biological materials, and particularly relates to a gelatin-based micro-nano fiber membrane material prepared by needle-free electrospinning and its application, a preparation method of the gelatin-based micro-nano fiber membrane material, and a method for preparing gelatin-based micro-nano fiber membrane material. Electrospinning machine for nanofibrous membrane materials. Background technique [0002] Under the action of a high-voltage electric field, the charged polymer solution or melt will form a cone, which is the so-called "Taylor cone"; continue to increase the electric field strength, and the polymer solution or melt will form a cone from the "Taylor cone". squirt. The jet stream oscillates under the action of a high-voltage electric field, which produces irregular spiral motion with a high frequency, resulting in the rapid thinning of the jet stream, rapid volatilization of the solve...

Claims

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Application Information

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IPC IPC(8): D04H1/4382D04H1/728D01F1/10D01D5/00A61L15/32A61L15/44A61L27/22A61L27/60A61L27/54A61K47/42
Inventor 郭燕川卢伟鹏徐海涛
Owner 杭州中科润德生物技术发展有限公司
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