Fiber compact double-layered composite film, preparation method thereof and application of fiber compact double-layered composite film

A double-layer composite, fiber-dense technology, used in applications, medical science, surgery, etc., can solve the problems of insufficient histocompatibility, limited physical barrier, and poor fixation, and achieve stable and excellent properties. The effect of biocompatibility

Active Publication Date: 2012-07-04
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still many problems in the use of these materials, such as poor fixation, poor tissue compatibility, insufficient in vivo degradability, and limited physical barriers.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Solution preparation: mix PLGA (weight average molecular weight of 60,000, wherein the molar ratio of lactide to glycolide is 3:1) and PELA (weight average molecular weight of 10,000, wherein polylactide and polyethylene The molar ratio of diol is 50:50) is dissolved in the mixed solvent of N,N-dimethylformamide (DMF) and acetone (volume ratio is 5:5), obtains the PLGA that mass volume percent concentration is 50% and PELA mixed solution. In the solution, the mass ratio of PLGA to PELA is 85:15.

[0031] (2) Preparation of dense scraped film layer: set the distance between the scraper and the roller to 15 μm, and set the roller speed to 3 cm / min. Slowly drop the solution prepared in step (1) onto the surface of the roller to completely cover it. Rotate the roller to spread the solution and dry it in vacuum to obtain a dense film.

[0032] Or place the prepared solution in the feeding syringe of the electrospinning equipment. First, carry out electrospinning on t...

Embodiment 2

[0036] (1) Solution preparation: mix PLGA (weight average molecular weight of 80,000, wherein the molar ratio of lactide to glycolide is 95:5) and PELA (weight average molecular weight of 2000, wherein polylactide and polyethylene glycol The molar ratio of alcohol is 9: 1) is dissolved in the mixed solvent of N, N-dimethylformamide (DMF) and acetone (volume ratio is 1: 9), obtains the PLGA and the PLGA that the mass volume percentage concentration is 15%. A mixed solution of PELA. In the solution, the mass ratio of PLGA to PELA is 95:5.

[0037] (2) Preparation of dense scraped film layer: set the distance between the scraper and the roller to 15 μm, and set the roller speed to 3 cm / min. Slowly drop the solution prepared in (1) onto the roller surface to completely cover it. Rotate the roller to spread the solution and dry it in vacuum to obtain a dense film.

[0038] Or place the prepared solution in the feeding syringe of the electrospinning equipment. First perform elec...

Embodiment 3

[0042] (1) Solution preparation: mix PLGA (weight average molecular weight of 200,000, wherein the molar ratio of lactide to glycolide is 4:6) and PELA (weight average molecular weight of 50,000, wherein polylactide and polyethylene The molar ratio of diol is 2: 8) is dissolved in the mixed solvent of N, N-dimethylformamide (DMF) and acetone (volume ratio is 9: 1), obtains the PLGA that mass volume percent concentration is 40% and PELA mixed solution. In the solution, the mass ratio of PLGA to PELA is 90:10.

[0043] (2) Preparation of dense scraped film layer: set the distance between the scraper and the roller to 15 μm, and set the roller speed to 3 cm / min. Slowly drop the solution prepared in (1) onto the roller surface to completely cover it. Rotate the roller to spread the solution and dry it in vacuum to obtain a dense film.

[0044] Or place the prepared solution in the feeding syringe of the electrospinning equipment. First perform electrospinning on the roller for...

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Abstract

The invention relates to a fiber compact double-layered composite film, which consists of two layers including a smooth compact film and a nano fiber film. The two films are combined tightly and cannot be separated. A preparation method of the fiber compact double-layered composite film includes mixing and dissolving polylactic-co-glycolic acid and polylactide-b-polyethylene glycol into N, N-dimethylformamide or acetone or mixture of the N, N- dimethylformamide and the acetone so as to obtain uniform polymer solution; then knifing the polymer solution on a roller or realizing electrostatic spinning on the roller and then drying the roller after heating the roller so as to obtain the compact film layer; and finally realizing electrostatic spinning on the compact film to obtain a fiber film layer, and accordingly obtaining the fiber compact double-layered composite film. The fiber compact double-layered composite film has excellent biocompatibility, biodegradation and biological absorption, and simultaneously has the advantages of light weight and softness. Besides, mechanical property and degradation period of the fiber compact double-layered composite film can be flexibly adjusted according to service needs.

Description

technical field [0001] The invention relates to a biodegradable and bioabsorbable postoperative anti-adhesion fiber-dense double-layer composite film, its preparation method and its application, in particular to a polylactide (PLGA) and polylactide-b -A fiber-dense double-layer composite membrane prepared from polyethylene glycol (PELA), its preparation method and its use. Background technique [0002] Postoperative adhesions are a scientific problem with high incidence and recurrence rates in the field of surgery. After abdominal or thoracic surgery, adhesions are especially prevalent and seriously affect people's quality of life. Data show that the incidence of adhesions after abdominal surgery is higher than 90%. The sequelae accompanying adhesions, such as intestinal obstruction, chronic pelvic pain, and infertility, bring great suffering to patients and seriously affect people's quality of life. More importantly, the occurrence of adhesion will bring great risks to t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B19/00A61L31/12A61L31/14A61B90/00
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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