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Preparation method of cortex phellodendri composite biological glass tissue repair material

A bioglass, tissue repair technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of poor drug adhesion and poor mechanical properties, achieve good biodegradability, good biocompatibility, enhanced proliferation and The effect of differentiation

Inactive Publication Date: 2017-09-15
HEFEI CHUANGWO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in view of the existence of its amorphous silicon skeleton, bioglass still presents an amorphous form, poor mechanical properties, and poor drug adhesion, and its application in biomedical materials remains to be further developed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method of a Cortex Phellodendri composite biological glass tissue repair material, comprising the following steps:

[0023] Step 1: Wash the cork, and place it in a ventilated and dry place for air-drying, place the air-dried cork at 90 ° C for 8 minutes, put the dried cork into a pulverizer and pulverize the pulverized cork. 60 mesh sieve to get phellodendron powder;

[0024] Step 2: Weigh 2g of Cork Phellodendri powder, put it in a wide-mouth bottle containing 100ml of absolute ethanol, extract at a constant temperature of 40°C for 10h, filter the solution and take out the filter residue, add 50ml of absolute ethanol to the filter residue and Extract at a constant temperature of 40°C for 20min, filter the two filtrates together, perform rotary evaporation at 58°C, and concentrate to a total volume of 5ml to obtain Phellodendron chinensis extract;

[0025] Step 3: Dissolve the polylactic acid particles in chloroform, prepare a 6.5 wt% solution, ultrasoni...

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PUM

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Abstract

The invention relates to a preparation method of a cortex phellodendri composite biological glass tissue repair material, and belongs to the field of biomedical materials, wherein the preparation method comprises: preparing a cortex phellodendri extraction liquid, preparing a polylactic acid solution, preparing a biological glass solution, and carrying out electrospinning to obtain the repair material. According to the present invention, the cortex phellodendri has the antibacterial effect, the polylactic acid can improve the mechanical property of the material, and the biological glass can improve the pharmaceutical property of the material; and the prepared tissue repair material has advantages of good mechanical property, good tissue repair property, and good drug adhesion property.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of a Cortex Phellodendri composite biological glass tissue repair material. Background technique [0002] Since the discovery of bioglass, people have paid more attention to the influence of bioglass components on biological activity. The rise of nanotechnology has made people realize that structure also has an important influence on biological activity, and pay more attention to the effect of size effect and microscopic fine structure on the structure and properties of materials. Nanoscale bioglass and mesoporous bioglass developed and designed from the perspective of nanometer size have attracted the attention of scholars at home and abroad. Bioglass can activate cell genes, which is beneficial to enhance the proliferation and differentiation of cells, and has the effect of osteoinduction and osteoconduction. However, due to the existence o...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/36A61L27/56A61L27/58A61L27/54A61L27/50
CPCA61L27/46A61L27/3637A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/112A61L2300/30A61L2300/404A61L2300/412A61L2300/604A61L2430/02C08L67/04
Inventor 王吉鹏
Owner HEFEI CHUANGWO TECH CO LTD
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