Method for manufacturing micro-pipeline stent with nano structure on inner wall

Abstract

The invention discloses a method for manufacturing a micro-pipeline stent with a nano structure on the inner wall. The micro-pipeline stent with a nano structure on the inner wall is manufactured by the steps of manufacturing a template, preparing a macromolecular solution, casting, stripping, ordering for bonding, and the like through combining a thermal fluid reflux and plasma induction coupling technology; and the micro-pipeline stent with a nano structure on the inner wall has the advantages of favorable biocompatibility, biodegradability and biological absorbability and novel and unique structure, is beneficial to the growth and spreading of cells, can improve the function of the stent in a living body and maintain the normal metabolism of the cells and has wide application prospect in the fields of transportation of nutrient substances, exchange of metabolic products, a culture base plate of active substances, a stent material of sealed space, tissue engineering stent materials, and the like.

Description

technical field

[0001] The invention relates to a preparation method of a micro-pipe support, more specifically, a preparation method of a micro-pipe support with a nanostructure on the inner wall. Background technique

[0002] Over the past few decades, the intersection of extracellular scaffold engineering, cytology, and bioactive substances has led to artificially cultured tissues in the laboratory, in which cells are often cultured in three-dimensional tissue-degradable These scaffolds have many uses, such as substrates for cell adhesion and transfer, nutrient exchange, immobilization or retention of cells and bioactive factors. However, tissue engineering scaffolds have always faced a challenge. It cannot exchange nutrients and metabolites like real microvessels, so that cultured cells cannot normally obtain enough nutrients and oxygen to perform normal functions. A possible solution to this problem is to provide an artificial micro-plumbing system to support normal me...

Examples

Embodiment 1

[0015] Prepare the micropipe scaffold with nanostructures on the inner wall as follows:

[0016] (1) Prepare the template: select an aluminum foil with a thickness of 175 μm and a purity greater than 99.999%, and wash it with ethanol, acetone, and deionized water in sequence; mix perchloric acid and ethanol at a volume ratio of 1:5 to obtain an electrolyte, wherein, high The mass purity of chloric acid is 60%, and the mass purity of ethanol is 99.8%; The aluminum foil that has cleaned is put into electrolytic solution, under the voltage of 20V electrolytic polishing 2 minutes, wherein, described polishing comprises first at 350r / min Polishing at a rotating speed for 10 seconds, then polishing at a rotating speed of 500r / min for 25 seconds to obtain an electrolytic polishing layer, then spraying a 60 μm cathode film photoresist material on the electrolytic polishing layer, and irradiating for 10 minutes under an ultraviolet lamp; The shape of the pipe support is transferred to ...

technical field

[0001] The invention relates to a preparation method of a micro-pipe support, more specifically, a preparation method of a micro-pipe support with a nanostructure on the inner wall. Background technique

[0002] Over the past few decades, the intersection of extracellular scaffold engineering, cytology, and bioactive substances has led to artificially cultured tissues in the laboratory, in which cells are often cultured in three-dimensional tissue-degradable These scaffolds have many uses, such as substrates for cell adhesion and transfer, nutrient exchange, immobilization or retention of cells and bioactive factors. However, tissue engineering scaffolds have always faced a challenge. It cannot exchange nutrients and metabolites like real microvessels, so that cultured cells cannot normally obtain enough nutrients and oxygen to perform normal functions. A possible solution to this problem is to provide an artificial micro-plumbing system to support normal me...

Examples

Embodiment 1

[0015] Prepare the micropipe scaffold with nanostructures on the inner wall as follows:

[0016] (1) Prepare the template: select an aluminum foil with a thickness of 175 μm and a purity greater than 99.999%, and wash it with ethanol, acetone, and deionized water in sequence; mix perchloric acid and ethanol at a volume ratio of 1:5 to obtain an electrolyte, wherein, high The mass purity of chloric acid is 60%, and the mass purity of ethanol is 99.8%; The aluminum foil that has cleaned is put into electrolytic solution, under the voltage of 20V electrolytic polishing 2 minutes, wherein, described polishing comprises first at 350r / min Polishing at a rotating speed for 10 seconds, then polishing at a rotating speed of 500r / min for 25 seconds to obtain an electrolytic polishing layer, then spraying a 60 μm cathode film photoresist material on the electrolytic polishing layer, and irradiating for 10 minutes under an ultraviolet lamp; The shape of the pipe support is transferred to ...