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Absorbable endocranium healing patch and preparation method thereof

A dura mater and patch technology, applied in the field of absorbable dura mater repair patch and its preparation, can solve the problems of anti-leakage and limited mechanical properties, slow absorption, etc., to protect brain tissue, improve cell growth, and promote The effect of cell growth

Inactive Publication Date: 2013-12-04
TIANJIN KANGER MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dura mater material prepared by it has good biocompatibility, non-toxicity, no antigen reaction, antibacterial, no edge detachment during suturing, can provide a three-dimensional scaffold structure for cell growth, and can be slowly absorbed in the human body. It can be used for dura mater defects The repair and repair of pleura, heart color defect, peritoneum, abdominal myofascial defect repair, anti-adhesion and other purposes, but its leakage resistance and mechanical properties are limited

Method used

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  • Absorbable endocranium healing patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Preparation of anti-seepage layer

[0044] Put polydioxanone in a hot press, turn on the heater of the hot press for heating, and heat press at an absolute pressure of 60MPa and a temperature of 100°C for 20s to obtain a 20mm×20mm×0.05mm anti-seepage layer;

[0045] Under the absolute pressure of 100-155mmHg, the permeability of the anti-seepage layer to physiological saline was measured, and the results showed that the anti-seepage layer remained impermeable for 1 minute under 100-155mmHg;

[0046] 2. Preparation of mesh sheet

[0047] Use a braiding machine to weave the linear materials lactic acid-glycolic acid copolymer and polydioxanone with a diameter of 0.05mm in a horizontal and vertical direction to form a mesh sheet of 20mm×20mm×0.1mm;

[0048] Adopt GB / T 1040-2:2006 method to measure the tensile strength and the elongation at break of the mesh sheet, the results are shown in Table 1;

[0049] 3. Preparation of double-layer composite materials

[0050] ...

Embodiment 2

[0055] 1. Preparation of anti-seepage layer

[0056] Put trimethylene carbonate-glycolide copolymer in a hot press, turn on the heater of the hot press for heating, and heat press for 10s at an absolute pressure of 30MPa and a temperature of 130°C to obtain a 60mm×40mm× 0.1mm anti-seepage layer, the anti-seepage layer remains impermeable for 1 minute under 100-155mmHg;

[0057] 2. Preparation of mesh sheet

[0058] Use a braiding machine to weave the linear materials lactide trimethylene carbonate copolymer and polydioxanone with a diameter of 0.1mm in a crosswise and vertical way to form a mesh sheet of 60mm×40mm×0.2mm; The tensile strength and elongation at break results of the mesh sheet are shown in Table 1;

[0059] 3. Preparation of double-layer composite materials

[0060] Use a heat sealing machine to heat seal the above-prepared anti-seepage layer and mesh sheet at an absolute pressure of 30 MPa and a temperature of 120 ° C for 20 seconds to obtain a composite mate...

Embodiment 3

[0065] 1. Preparation of anti-seepage layer

[0066] The dried p-dioxanone-lactide copolymer particles are fed into the extruder, and through plasticizing extrusion, forming tube blanks, inflation molding, cooling, pulling and other processes, the 80mm×60mm× 0.05mm anti-seepage layer, in which the extrusion temperature is controlled at 140°C and the pulling speed is 3 m / min; the prepared anti-seepage layer remains impermeable for 1 minute at 100-155mmHg;

[0067] 2. Preparation of mesh sheet

[0068] Use a knitting machine to weave linear materials lactic acid-glycolic acid copolymer and polydioxanone with a diameter of 0.05mm in a horizontal and vertical direction to form a mesh sheet of 80mm×60mm×0.1mm; the mesh sheet The results of tensile strength and elongation at break are shown in Table 1;

[0069] 3. Preparation of double-layer composite materials

[0070] Use a heat sealing machine to heat seal the above-prepared anti-seepage layer and mesh sheet at an absolute pre...

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Abstract

The invention discloses an absorbable endocranium healing patch and a preparation method thereof. The preparation method comprises: firstly processing a degradable high molecular material into a film impervious layer; at the same time weaving the degradable high molecular material into a netted sheet layer; then performing heat sealing processing on the film impervious layer and the netted sheet layer to prepare a double-layer composite material containing the impervious layer and the netted layer; and finally coating a bioactive component on the surface of the netted layer of the double-layer composite material to prepare the absorbable endocranium healing patch. The absorbable endocranium healing patch has excellent biodegradability, biocompatibility, biological absorbability, excellent flexibility, no repulsion reaction, and no toxicity, no carcinogenic and teratogenic effects, and can be completely absorbed after cambium is generated, and thus the absorbable endocranium healing patch can be more safely and more effectively applied to endocranium healing correlated medical operations.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an absorbable dura mater repair patch and a preparation method thereof. Background technique [0002] The dura mater is a thick and tough double-layered membrane. The outer layer is called the periosteum, which is the periosteum on the inner surface of the skull and is only loosely attached to the calvaria. The inner layer is called the meningeal layer, which is thicker and tougher than the outer layer. The dura mater is continuous at the foramen magnum, and the main function of the dura mater is to protect the brain. During neurosurgical craniotomy, the dura mater must be incised. Dural hemorrhage, electrocoagulation to stop bleeding, resection of tumor invasion into the dura mater, and traumatic dura mater injury can all lead to dural defect. In neurosurgery, the integrity of the dura mater is very important. Dural repair materials play an important role in reb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/54A61L27/58A61L27/24A61L27/18
Inventor 赵文和李春来兰成营
Owner TIANJIN KANGER MEDICAL DEVICE
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