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Adsorbable hemostatic ligation clip

A ligation clip and lactide technology, applied in wound clips, medical science, surgery, etc., can solve the problems of insufficient softness, damage, poor hydrophilicity, etc., and achieve soft materials, increased hydrophilicity, and good compatibility Effect

Active Publication Date: 2007-12-05
HANGZHOU SUNSTONE TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the inner layer is made of glycolide-trimethyl propionate copolymer, it has poor hydrophilicity and is not soft enough, which may sometimes damage the tubular tissues or other intraluminal tissues in the human body.

Method used

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  • Adsorbable hemostatic ligation clip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of polydioxanone material:

[0025] Put 200 grams of polymer-grade p-dioxanone in the reactor, add 0.01% stannous octoate catalyst, react under vacuum conditions at 140°C for 6 hours, and add the reactant to the extruder at 140°C to obtain a diameter Particles of 1-2 mm and 5-10 mm in length of polydioxanone, the above pellets were vacuum dried at 50° C. for 24 hours and weighed 187 grams, with a yield of 93.5%. Using phenol / 1,1,2,2-tetrachloroethane (2:3 / W:W) mixed solution as solvent, using Ubbelohde viscometer in a constant temperature water bath at 25 ℃, measured polydioxanone The intrinsic viscosity of 2.78dl / g.

[0026] Preparation of Polyglycolide:

[0027] The polymer grade glycolide was placed in the reactor, stannous octoate catalyst was added, and the reaction was carried out under vacuum conditions at 240°C for an appropriate time. 10 mm pellets of polyglycolide, the above pellets were vacuum dried at 50°C for 24 hours. The melt index of poly...

Embodiment 2

[0030] Preparation of polydioxanone material:

[0031] Put 200 grams of polymer-grade p-dioxanone in the reactor, add 0.02% stannous octoate catalyst, and react under vacuum conditions at 140 ° C for 10 hours. Add the reactant to the extruder at 140 ° C to obtain a diameter Granules of 1-2 mm and 5-10 mm in length of polydioxanone, the above pellets were vacuum-dried at 50° C. for 24 hours and weighed 196 grams, with a yield of 98%. Using phenol / 1,1,2,2-tetrachloroethane (2:3 / W:W) mixed solution as solvent, using Ubbelohde viscometer in a constant temperature water bath at 25 ℃, measured polydioxanone The intrinsic viscosity of 4.78dl / g.

[0032] Processing of the absorbable hemostatic ligation clip: The above-synthesized polydioxanone is processed into an inner layer card by an injection molding method, the temperature is 175-180° C., and the tensile strength of the inner layer is 78Mpa after testing.

Embodiment 3

[0034] Preparation of polydioxanone material:

[0035] Put 200 grams of polymer grade p-dioxanone in the reactor, add 0.01% stannous octoate catalyst, react under vacuum conditions at 140 ° C for 10 hours, and add the reactant to the extruder at 140 ° C to obtain a diameter Granules of 1-2 mm and 5-10 mm long polydioxanone, the above pellets were vacuum-dried at 50° C. for 24 hours and weighed 190 g, the yield was 95%. Using phenol / 1,1,2,2-tetrachloroethane (2:3 / W:W) mixed solution as solvent, using Ubbelohde viscometer in a constant temperature water bath at 25 ℃, measured polydioxanone The intrinsic viscosity of 3.29dl / g.

[0036] Processing of the absorbable hemostatic ligation clip: The above-synthesized polydioxanone is processed into an inner layer card by an injection molding method, the temperature is 170-175° C., and the tensile strength of the inner layer is 70 MPa after testing.

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Abstract

The present invention discloses one kind of hemostatic ligating clip of absorbable material for surgical abdominoscope operation. The hemostatic ligating clip includes one outer layer of polyglycolide and one inner layer of poly-p-dioxanone or p-dioxanone-lactide copolymer. The hemostatic ligating clip made of materials with high hydrophilicity and flexibility has high compatibility to skin and tissue, no injury to the tissue of human body and the degradation speed determined by the outer layer.

Description

technical field [0001] The invention relates to a special consumable for performing laparoscopic surgery in surgery, and more particularly, the invention relates to a hemostatic ligation clip made of absorbable material. Background technique [0002] In laparoscopic surgery, metal clips are often used to clamp intracavity tissue, seal tubular tissue in the human body, prevent liquid leakage, and play the role of hemostasis or ligation. Metal clips such as stainless steel clips and titanium clips cannot be degraded and absorbed, and may produce foreign body reactions or irritation to tissues in the body for a long time, resulting in inflammation, pain and other diseases; at the same time, due to their opacity, X-ray inspection is often affected. In the 1980s, hemostatic ligation clips made of absorbable materials appeared (Surgical fasteners made from glycolide-rich polymer blends, Ethicon, Appl. No.: 146014, Filed: January 20, 1988), and the materials used were mainly polyet...

Claims

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Application Information

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IPC IPC(8): A61L17/10A61B17/122
Inventor 熊成东石磊张胜蓝李庆
Owner HANGZHOU SUNSTONE TECH CO LTD
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