Novel micro-needle patch containing degradable polymer and preparation method thereof

A technology of polymer and micro-needle patch, applied in the field of medicine, can solve the problems of a single variety of biodegradable polymers and the inability to meet the requirements of controlled release, etc.

Inactive Publication Date: 2011-04-06
河南羚锐制药股份有限公司北京药物研究院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the biodegradable polymers used for the preparation of microneedles reported in the literature and patents are single in variety and cannot meet the requirements for the controlled release of many different drugs. Dioxanone (PDO) can be combined with various pharmaceutical conventional drugs. Polymers polymerize with each other to meet the needs of different microneedle patches

Method used

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  • Novel micro-needle patch containing degradable polymer and preparation method thereof

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Embodiment 1

[0018] Embodiment 1: the P (PDO-LA) (95: 5) microneedle patch of preparation bovine serum albumin (BSA)

[0019] The mold for preparing the microneedles was cleaned, dried in an oven, and then placed on a petri dish. Disperse 50mg of bovine serum albumin (BSA) powder in acetonitrile at a concentration of 10% (w / v), sonicate, mix, and filter so that the particle size of bovine serum albumin (BSA) powder is 1-30 μm; Disperse in acetonitrile so that the concentration is 20% (w / v); then pour it into a polydimethylsiloxane (PDMS) elastomer mold, dry under reduced pressure for 2-5 minutes, and completely evaporate the solvent. Clean up the bovine serum albumin (BSA) powder remaining on the outside of the mold, then melt 1.0g of P(PDO-LA) (95:5) polymer, and pour it into the above PDMS mold under high temperature and vacuum conditions (110oC, -70kPa), Continue for 10-20 minutes, and then cool to room temperature, then the microneedle patch can be taken out from the mold to prepare a...

Embodiment 2

[0020] Example 2: Preparation of P(PDO-LA) (95:5) microneedle patch of risperidone microspheres

[0021]Dissolve 50mg risperidone and 0.2g P(PDO-LA) (5:95) in a mixed solution of dichloromethane and methanol, stir to dissolve, slowly drop this solution into 2mL PVA aqueous solution (10%), and Stir while adding dropwise, and stir at high speed for 5 minutes after the dropwise addition is completed; then slowly add this emulsion into 50 mL of PVA solution with a concentration of 2%, stir while adding dropwise, at a speed of 200 r / min, stir for 4 hours, and volatilize the organic solvent to make it solidified. Then centrifuge, wash, and freeze-dry to obtain microspheres with a particle size of 20-50 μm. The microspheres were placed in a clean PDMS mold, and then 1.0g of P(PDO-LA) (95:5) polymer was melted and poured into polydimethylsiloxane under high temperature vacuum conditions (110oC, -70kPa) (PDMS) elastomer mold for 10-20 minutes, and then cooled to room temperature, the...

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Abstract

The invention relates to a micro-needle patch containing a biodegradable polymer and a preparation method thereof. The biodegradable polymer is a poly(p-dioxanone) having the molecular weight of 1,000 to 1,000,000 Daltons or copolymer containing a p-dioxanone, such as copolymer of the p-dioxanone and a lactide, copolymer of the p-dioxanone and a glycolide, and the like. The micro-needle patch has no limitation on hydrophilic and hydrophobic property and molecular weight of the medicine, and does not cause any pain and stimulation, thereby improving the medicine bioavailability and the adaptability to the patient.

Description

technical field [0001] The invention relates to a microneedle patch containing a biodegradable polymer and a preparation method thereof, belonging to the field of medicine. technical background [0002] Biological macromolecular drugs such as peptides or proteins with biological activity play an increasingly important role in the treatment of tumors, diabetes, hepatitis and other diseases and tissue regeneration due to their unique therapeutic effects and good curative effects. However, due to its high molecular weight, difficulty in permeating biofilms, easy degradation by the gastrointestinal tract, and short half-life in vivo, the main clinical dosage forms are aqueous solutions or lyophilized powder injections. The transport efficiency of drugs to antigen-presenting cells (APCs) such as phagocytes and dendritic cells is very low, and most drugs have been degraded before being transported to cells, resulting in low levels of antigen expression and presentation, and poor i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/70A61K47/34A61M37/00
Inventor 赵慧珍武惠斌熊维政张军兵
Owner 河南羚锐制药股份有限公司北京药物研究院
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