Spinning solution, nuclear shell nanofiber as well as preparation method and application thereof

A nanofiber, spinning solution technology, applied in rayon manufacturing, fiber chemical characteristics, textiles and papermaking, etc., can solve problems such as high price

Inactive Publication Date: 2013-04-17
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The degradation of PPDO is mainly caused by the hydrolysis of the acetic acid bond on its molecular chain, and its degradation products are consistent with human metabolites, most of which are excreted from the respiratory tract, and a small amount is excreted from urine and feces, so it has excellent biocomp

Method used

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  • Spinning solution, nuclear shell nanofiber as well as preparation method and application thereof
  • Spinning solution, nuclear shell nanofiber as well as preparation method and application thereof
  • Spinning solution, nuclear shell nanofiber as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] Weigh a certain amount of polyvinyl alcohol (PVA, average polymerization degree 1700, alcoholysis degree 88%) according to the formula and dissolve it in a certain volume of distilled water, the concentration of PVA is 4%wt / v (0.04g / ml), Heated and stirred at 80°C for 12h, and simultaneously weighed a certain amount of three different molecular weight polyethylene glycol-b-polydioxanone (PEG-b-PPDO, namely PEDO, its molecular structure is two blocks, The weight-average molecular weights were 9764, 3837 and 2716, respectively, and the mass ratios of the hydrophilic block PEG to the lipophilic block PPDO were 1:4, 1:0.9, and 1:0.7) were dissolved in a certain volume of distilled water in order to obtain three A PEDO solution and the concentrations of the three PEDO solutions are 1%wt / v (ie 0.01g / ml), heated and stirred at 30°C for 2h, and then the above PVA solution and each PEDO solution (ie PVA solution and three Any PEDO solution in the PEDO solution) the two are mixed...

Embodiment 2

[0104] Weigh a certain amount of polyvinyl alcohol (PVA, average polymerization degree 1700, alcoholysis degree 88%) according to the formula and dissolve it in a certain volume of distilled water, the concentration of PVA is 4%wt / v (0.04g / ml), Heated and stirred at 80°C for 12 hours, and at the same time weighed a certain amount of three different molecular structures of polyethylene glycol-b-polydioxanone (PEG-b-PPDO, PEDO, the molecular structures were diblock, Tri-block and multi-block, the weight-average molecular weights are 3837, 5670 and 15000, respectively, and the mass ratio of the hydrophilic block PEG to the lipophilic block PPDO is 1:0.9, 1:1.8 and 1:6.5 respectively) dissolved in A certain volume of distilled water in order to obtain three PEDO solutions and the concentration of the three PEDO solutions is 5%wt / v (ie 0.05g / ml), heated and stirred at 30°C for 2h, and then the above PVA solution was mixed with each PEDO solution (that is, PVA solution and any PEDO ...

Embodiment 3

[0106] Weigh a certain amount of polyvinyl alcohol (PVA, average degree of polymerization 1700, degree of alcoholysis 66%) according to the formula and dissolve it in a certain volume of distilled water, the concentration of PVA is 4%wt / v (ie 0.04g / ml), Heated and stirred at 80°C for 12h, and simultaneously weighed a certain amount of three different molecular weight polyethylene glycol-b-polydioxanone (PEG-b-PPDO, namely PEDO, its molecular structure is two blocks, The weight-average molecular weights were 9764, 3837 and 2716, respectively, and the mass ratios of the hydrophilic block PEG to the lipophilic block PPDO were 1:3.8, 1:0.9, and 1:0.35 respectively) were dissolved in a certain volume of distilled water in order to obtain three A PEDO solution and the concentrations of the three PEDO solutions are all 10%wt / v (ie 0.1g / ml), heated and stirred at 30°C for 2h, and then the above PVA solution and each PEDO solution (ie PVA solution and three Any PEDO solution in the PED...

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Abstract

The invention discloses a spinning solution, nuclear shell nanofiber as well as a preparation method and application thereof. A hydrophobic drug and polyvinyl alcohol (PVA)/polyethylene glycol-b-poly(p-dioxanone) (PEG-b-PPDO) are blended to obtain a spinning solution system, and the nuclear shell nanofiber is directly formed by utilizing a single-axis spinneret under a high-voltage electrostatic effect. The preparation method disclosed by the invention has the advantages of simple equipment, mild conditions, simple flow and low energy consumption, can be used for achieving the aims of high-efficiency embedding of the hydrophobic drug, controllable drug release speed and long sustained release time, and is very suitable for industrial production.

Description

technical field [0001] The invention relates to the preparation of a core-shell nanofiber and a long-acting sustained-release preparation of hydrophobic drugs based on the material. More specifically, the present invention relates to spinning dopes containing polyvinyl alcohol (PVA) / polyethylene glycol-b-polydioxanone (PEG-b-PPDO), optionally with a hydrophobic drug-containing core Shell nanofibers and methods for their preparation and use. Background technique [0002] The development of new pharmaceutical excipients and the promotion of dosage form optimization are one of the strategic tasks for the development of traditional Chinese medicine in China to be in line with international standards. At present, sustained-release agents are classified according to the selected materials and methods, mainly including matrix sustained-release, film-coated sustained-release, bioadhesive sustained-release and microsphere sustained-release. At the same time, the use of a slow-relea...

Claims

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Application Information

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IPC IPC(8): D01F8/10D01F8/16D01F1/10A61K47/34A61K47/32A61K45/00
Inventor 刘娅翟飞玉陈思翀王玉忠秦青敬新柯黄维郭德明
Owner SICHUAN UNIV
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