34results about How to "Release speed controllable" patented technology

The invention provides a polymer microsphere for oil field profile control and water plugging and a preparation method thereof. The polymer microsphere is of a three-layer spherical structure, and comprises a positive ion inner core, a middle oleophilic casing layer and an outer layer negative ion hydrophilic casing layer, wherein the positive ion inner core comprises acrylamide, cationic monomers and crosslinking agent copolymers; the middle oleophilic casing layer comprises acrylamide, oleophilic monomers and cross linking copolymers; the outer layer negative ion hydrophilic casing layer comprises acrylamide, anionic monomers and crosslinking agent copolymers. The polymer microsphere prepared according to the invention has the advantages that the particle diameter range is controllable in the dimension range of 1 to 500 mu. m; in the use process, the outer hydrophilic casing layer and the middle oleophilic casing layer are gradually degraded along with the prolonging of the water dissolution time; the inner core has good water absorption expansion performance; the dimension after the sufficient expansion reaches 30 to 1500 mu. m; good expansion performance and good plugging performance are realized. The polymer microsphere is solid powder; the storage is convenient; the stability is high; the validity period is 3 to 5 years; in the use process, the addition of other auxiliary agents is not needed; the polymer microsphere can be fast dispersed in the solvent.

The invention discloses a spinning solution, nuclear shell nanofiber as well as a preparation method and application thereof. A hydrophobic drug and polyvinyl alcohol (PVA) / polyethylene glycol-b-poly(p-dioxanone) (PEG-b-PPDO) are blended to obtain a spinning solution system, and the nuclear shell nanofiber is directly formed by utilizing a single-axis spinneret under a high-voltage electrostatic effect. The preparation method disclosed by the invention has the advantages of simple equipment, mild conditions, simple flow and low energy consumption, can be used for achieving the aims of high-efficiency embedding of the hydrophobic drug, controllable drug release speed and long sustained release time, and is very suitable for industrial production.

The invention discloses a thermo-sensitive coding microsphere carrier for drug controlled release and a preparation method of the microsphere carrier. The carrier is a hydrogel microsphere with an inverse opal structure. The main component of the microsphere is poly(N-isopropylacrylamide), which has a three-dimensional ordered nanometer porous structure for carrying multiple protein or polypeptide medicines. Contraction and expansion of nanometer holes can be controlled through temperature regulation, so that drug controlled release is achieved. The inverse opal hydrogel microsphere is prepared by taking a colloidal crystal microsphere as a template. The carrier is simple in preparation method, low in cost and convenient for large-scale production. The prepared coding carrier is non-toxic and is good in biocompatibility and controllability.

The invention discloses application of oleanolic acid in preparing a marine environment-friendly antifouling agent, and relates to an antifouling agent, in particular to application of a natural active material oleanolic acid as the marine environment-friendly antifouling agent. The oleanolic acid applied to a marine antifouling coating can prevent marine plants from adhering and growing on the surfaces of submarine artificial facilities such as the bottom of a ship, an offshore oil-gas platform, a buoyage, a wharf, a bridge pier, a seawater pipeline, an aquaculture net cage, and the like. The invention provides application of the oleanolic acid in preparing the marine environment-friendly antifouling agent and the marine antifouling coating.

In order to solve the problems of lacked denitrification carbon sources, short carbon source release time, poor controlled release performance of additionally added carbon source materials, easy secondary pollution generation and the like in the underground water nitrate pollution biological restoration process, the invention provides a preparation method of controlled release carbon source carriers, which belongs to the technical field of water treatment. Novel carbon source carrier materials using cyclodextrin as active controlled release ingredients comprise the preparation steps of cyclodextrin monomer polymerization, carbon source inclusion and pelleting forming. The preparation process of the invention is relatively simple, the prepared carbon source materials have good mechanical and hydraulic performance, and the long-time effectively controlled release of the carbon sources in the biological denitrification process can be realized.

A rocker landing ladder of a planet exploration vehicle used for releasing relates to a landing ladder which solves the problems that the existing landing ladder has a large size after being expanded and forms a connection inclined plane between a lander and the surface of the planet, and the inclined plane is not beneficial to the stable releasing of the exploration vehicle after being expanded. A transmission mechanism (31) is arranged below a car loading platform (15); a second chain / belt wheel (12) is fixedly arranged at one end of the lower end surface of the car loading platform (15); a first chain / belt wheel (6) and the second chain / belt wheel (12) are connected by a transmission chain / belt (18); the upper end of a main rocker (4) is articulated with the two ends of a driven shaft (32); the lower end of the main rocker (4) is arranged on a drive shaft (19) by a bearing; the output shaft of a drive motor (1) is fixedly connected with the central wheel of a harmonic reducer (2); the flexible wheel of the harmonic reducer (2) is fixedly connected with one end of the drive shaft (19). The landing ladder of the invention after being expanded forms a connection horizontal level between the lander and the surface of the planet to realize the stable releasing of the exploration vehicle.

The invention provides an antifouling agent, which is a natural active compound extracted from rotenone, and has the advantages of high performance, environmental friendliness and good lipophilicity. Its molecular formula is C23H22O6, the molecular weight is 394.42, the structural formula is disclosed in the specification.

The invention discloses a copper ion antibacterial hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, grafting small molecules containing two hydrazide groups onto water-soluble macromolecules containing carboxyl by utilizing a carbodiimide method, and then uniformly mixing the obtained product with a copper salt solution, so as to obtain the copper ion antibacterial hydrogel. The preparation method has the advantages that the preparation method is simple and efficient, the process conditions are mild, the copper ions are both a cross-linking agent and an antibacterial agent, and the prepared hydrogel has the advantages of good mechanical property, injectability, self-repairability, excellent antibacterial property, biocompatibility and the like, and can be widely applied to skin wound protection, infection treatment, gynecologic inflammation treatment and the like.

The invention relates to a calcium alginate porous membrane containing metal ion-carrying zirconium phosphate and a preparation method of the calcium alginate porous membrane, and belongs to the fieldof biomedical materials. The calcium alginate porous membrane containing metal ion-carrying zirconium phosphate is characterized in that the matrix material of the porous membrane is composed of calcium alginate, and metal ion-carrying zirconium phosphate is uniformly dispersed in the calcium alginate matrix. Functional metal ion-carrying zirconium phosphate is added on the basis of calcium alginate, so that the calcium alginate porous membrane has better biomedical performance than that of pure calcium alginate as wound dressing, and can replace the pure calcium alginate dressing to be applied to management of skin wounds caused by various diseases accordingly. The preparation technology is simple, the manufacturing cost is relatively low, and large-scale production can be realized.

The invention belongs to the technical field of disinfectants, and particularly relates to a slow-release chlorine dioxide disinfectant and a preparation method thereof. The invention discloses a slow-release chlorine dioxide disinfectant. The disinfectant comprises a slow-release agent and a chlorine dioxide generator, wherein the chlorine dioxide generator comprises the following components in parts by weight: 10-20 parts of chlorite, 10-15 parts of an activating agent and 3-6 parts of a filling agent. According to the slow-release chlorine dioxide disinfectant prepared by the invention, theaction of the external environment on chlorine dioxide is isolated, the thermal stability, the light stability and the transportation impact stability of chlorine dioxide are improved, and the slow-release chlorine dioxide disinfectant has high safety, controllable release speed and double effects of slow release and safety explosion prevention; the initial chlorine dioxide content and the long-time chlorine dioxide content of the slow-release chlorine dioxide disinfectant prepared by the method are optimal for air purification effect, escherichia coli sterilization effect and formaldehyde removal effect, and the slow-release chlorine dioxide disinfectant is low in unit disinfection efficiency cost, convenient to use and wide in applicability.

The invention discloses a sandwich layer slow-release birth control material, which is formed by superposing hybrid material layers and complexing polymer-matrix composite material layers in a staggered mode, and the bottom layer and the top layer are the hybrid material layers consisting of polyving akohol and 10 to 40 weight percent of SiO2; the complexing polymer-matrix composite material layers consist of the polyving akohol, 10 and 40 weight percent of SiO2 and 10 and 40 weight percent of copper salt. The sandwich layer slow-release birth control material can release copper ions slowly, reduces the phenomenon of the burst release of the copper ions caused by the conventional metal copper birth-control device and the nanometer copper / low-density polyethylene birth-control device, andeliminate side effects such as massive hemorrhage, underbelly pain, pelvic inflammatory disease and the like caused by the burst release of the copper ions during initial implantation. The release process comprises that the copper ions dissociated in an intermediate layer of a composite material are diffused towards a surface layer under the action of concentration gradient; the copper ions diffused to the surface layer are diffused to an interface where the material is contacted with body fluid of a human body; and finally, the copper ions are diffused to the body fluid of the human body through the interface. The sandwich layer slow-release birth control material prolongs a path for diffusing medicaments, increases the resistance of medicament release, and slows down the release speed of the copper ions.

A preparation method of Chinese mugwort oil ointment is characterized by including the steps of Chinese mugwort oil preparation, Chinese mugwort oil inclusion compound preparation and ointment base preparation to finally obtain the Chinese mugwort oil ointment. The ointment has antibacterial, anti-inflammatory and pain alleviating functions.

The invention relates to a compound with antifouling activity and the distilling method as well as the application, in particular to an isoquinoline compound, and provides a compound with antifouling activity and the distilling method as well as the application. The compound is 3-methoxy-5 hydroxy-7-aldehyde group isoquinoline, and the molecular formula is C11H9NO3. Dry root of excoecaria agallocha is crushed to obtain root shivers; the shivers are dipped into solvents to obtain extracting solutions; the extracting solution goes through filtration and decompression, and the dry solvent is made into extracts; the extracts are scattered in water and distilled with ethyl acetate, which is removed to obtain crude products; the crude products are processed with petroleum aether; the acetone is used as eluent to purify the silica gel column, which is re-crystallized in the acetone. And then, methanol is used as solvents to refine the silica gel column to obtain the pure compound with the antifouling activity (3-methoxy-5 hydroxy-7-aldehyde group isoquinoline). The compound can be used for producing high-efficiency antifouling agents.

Chinese mugwort oil ointment is characterized in that the ointment is prepared from a Chinese mugwort oil clathrate compound and an ointment substrate; the Chinese mugwort oil ointment is obtained byadding the Chinese mugwort oil clathrate compound into the ointment substrate, homogenizing by using a homogenizer for 10 to 50min under the condition of keeping vacuum pressure of 0.09Mpa, and subpackaging. The ointment has an antibacterial effect, an anti-inflammatory effect and an analgesic effect.

The invention relates to a compound with antifouling activity and the distilling method as well as the application, in particular to an isoquinoline compound, and provides a compound with antifouling activity and the distilling method as well as the application. The compound is 3-methoxy-5 hydroxy-7-aldehyde group isoquinoline, and the molecular formula is C11H9NO3. Dry root of excoecaria agallocha is crushed to obtain root shivers; the shivers are dipped into solvents to obtain extracting solutions; the extracting solution goes through filtration and decompression, and the dry solvent is made into extracts; the extracts are scattered in water and distilled with ethyl acetate, which is removed to obtain crude products; the crude products are processed with petroleum aether; the acetone isused as eluent to purify the silica gel column, which is re-crystallized in the acetone. And then, methanol is used as solvents to refine the silica gel column to obtain the pure compound with the antifouling activity (3-methoxy-5 hydroxy-7-aldehyde group isoquinoline). The compound can be used for producing high-efficiency antifouling agents.

The invention provides a damping coating for preventing termites. The damping coating is prepared from 20 to 28 weight percent of matrix resin, 15 to 20 weight percent of inorganic filler, 5 to 10 weight percent of wood fiber, 15 to 25 weight percent of waste rubber powder, 5 to 10 weight percent of microcapsule suspension containing insecticide and 5 to 15 weight percent of water. The damping coating for preventing termites, which is provided by the invention, has the characteristics of termite prevention, good chemical stability, controllable release speed, good damping effect, low cost and the like.

The invention discloses a method for preparing a degradable antibacterial medical dressing material. The method comprises the following steps: S1, establishing a drug-loading system: mixing laponite LAP and an anti-inflammatory drug according to a ratio of (0.1-1):1, and performing stirring to wrap the anti-inflammatory drug in the laponite LAP to prepare an LAP-anti-inflammatory drug system; andS2, dissolving polylactic acid PLA or polycaprolactone PCL or poly(DL-lactic acid) PDLLA in chloroform or dichloromethane or N,N-dimethylformamide DMF or hexafluoroisopropanol HFIP to prepare a solution of 10-50% w / v, then performing mixing with the LAP-anti-inflammatory drug system prepared in the S1, and performing magnetic stirring to make the mixture be dissolved to obtain an electro-spinningsolution. The whole method has the advantages such as simple operation, low cost, mild conditions, and environmental friendliness. The cytotoxicity detected by an MTT reagent shows that the dressing film material is non-cytotoxic, namely the cell compatibility is good. The in vitro drug release experiment shows that the dressing film material has a controllable drug release rate, and the drug loading efficiency is high.

The invention relates to a multiphase emulsion method for preparing metoprolol succinate sustained-release pellets. The preparation steps are as follows: preparation of capsule material solution, preparation of capsule core solution, preparation of protective colloid solution, adding Sorbitan laurate, and then slowly and evenly add the capsule core solution to make a uniform water-in-oil emulsion, slowly add the above water-in-oil emulsion to the protective colloid solution to make a uniform multi-phase emulsion , slowly heating, filtering, vacuum drying, and sieving to make pellets. The present invention adopts the mixture of cellulose acetate and ethyl cellulose as the capsule material, so that the slow-release effect of the medicine is more obvious, and the release speed of the medicine is easier to control; sorbitan laurate is used as the emulsifier , using hydroxypropyl cellulose as a dispersant, polyvinyl alcohol as an emulsion protective colloid, and sorbitan laurate as an emulsifier, the emulsion is relatively stable, the product particles are uniform, and the surface of the capsule wall is smooth.

The invention discloses a sandwich layer slow-release birth control material, which is formed by superposing hybrid material layers and complexing polymer-matrix composite material layers in a staggered mode, and the bottom layer and the top layer are the hybrid material layers consisting of polyving akohol and 10 to 40 weight percent of SiO2; the complexing polymer-matrix composite material layers consist of the polyving akohol, 10 and 40 weight percent of SiO2 and 10 and 40 weight percent of copper salt. The sandwich layer slow-release birth control material can release copper ions slowly, reduces the phenomenon of the burst release of the copper ions caused by the conventional metal copper birth-control device and the nanometer copper / low-density polyethylene birth-control device, and eliminate side effects such as massive hemorrhage, underbelly pain, pelvic inflammatory disease and the like caused by the burst release of the copper ions during initial implantation. The release process comprises that the copper ions dissociated in an intermediate layer of a composite material are diffused towards a surface layer under the action of concentration gradient; the copper ions diffused to the surface layer are diffused to an interface where the material is contacted with body fluid of a human body; and finally, the copper ions are diffused to the body fluid of the human body through the interface. The sandwich layer slow-release birth control material prolongs a path for diffusing medicaments, increases the resistance of medicament release, and slows down the release speed of the copper ions.

A gossypol-type anti-fouling agent with excellent hipophilicity is perpared from toluene and cotton seed cake through mixing, high-speed stirring while adding cuprous oxide, vacuum distilling to remove toluene, drying and grinding. It can be used to prepare marine antifouling paint by proportionally mixing it with resin solution, plasticizer and filler.

The invention discloses the use of shikonin or a derivative thereof as an antifouling agent for preventing the attachment of large fouling organisms. The natural product shikonin or its derivatives in comfrey can prevent large-scale fouling organisms, especially marine large-scale fouling organisms, from attaching to the surface of artificial facilities in the sea such as ships, buoys, docks, marine monitoring equipment or aquaculture equipment. A natural and environmentally friendly antifouling agent that can be used in antifouling coatings.

A rocker landing ladder of a planet exploration vehicle used for releasing relates to a landing ladder which solves the problems that the existing landing ladder has a large size after being expanded and forms a connection inclined plane between a lander and the surface of the planet, and the inclined plane is not beneficial to the stable releasing of the exploration vehicle after being expanded. A transmission mechanism (31) is arranged below a car loading platform (15); a second chain / belt wheel (12) is fixedly arranged at one end of the lower end surface of the car loading platform (15); a first chain / belt wheel (6) and the second chain / belt wheel (12) are connected by a transmission chain / belt (18); the upper end of a main rocker (4) is articulated with the two ends of a driven shaft (32); the lower end of the main rocker (4) is arranged on a drive shaft (19) by a bearing; the output shaft of a drive motor (1) is fixedly connected with the central wheel of a harmonic reducer (2); the flexible wheel of the harmonic reducer (2) is fixedly connected with one end of the drive shaft (19). The landing ladder of the invention after being expanded forms a connection horizontal level between the lander and the surface of the planet to realize the stable releasing of the exploration vehicle.

The invention provides polymer microspheres for profile control and water plugging in oilfields and a preparation method thereof. The polymer microspheres have a three-layer spherical structure, including a cationic inner core, a middle lipophilic shell, and an outer anionic hydrophilic shell. The cationic inner core includes acrylamide, cationic monomer and crosslinker copolymer, the middle lipophilic shell layer includes acrylamide, lipophilic monomer and crosslinker copolymer, and the outer anionic hydrophilic shell layer includes acrylamide, anionic monomer and crosslinker copolymers. The polymer microspheres prepared by the present invention have a controllable particle size range of 1-500 μm. When in use, the outer hydrophilic shell and the middle lipophilic shell gradually degrade with the extension of the hydration time, and the inner core has excellent water absorption and swelling properties. Performance, the size after full expansion reaches 30~1500μm, with good expansion performance and strong plugging performance. The polymer microsphere of the present invention is a solid powder, which is convenient for storage and has good stability, and has a validity period of 3-5 years. It does not need to add other additives during use and can be quickly dispersed in a solvent.

The invention discloses application of oleanolic acid in preparing a marine environment-friendly antifouling agent, and relates to an antifouling agent, in particular to application of a natural active material oleanolic acid as the marine environment-friendly antifouling agent. The oleanolic acid applied to a marine antifouling coating can prevent marine plants from adhering and growing on the surfaces of submarine artificial facilities such as the bottom of a ship, an offshore oil-gas platform, a buoyage, a wharf, a bridge pier, a seawater pipeline, an aquaculture net cage, and the like. The invention provides application of the oleanolic acid in preparing the marine environment-friendly antifouling agent and the marine antifouling coating.

The invention discloses a demounting and mounting tool used for fixed type inner magnetic steel of a corrugated spring. The demounting and mounting tool comprises a sleeve, a locking sleeve, ring sleeves and a fixing ring. The sleeve is a hollow cylinder body, one end of the sleeve is provided with an outer thread, and the other end of the sleeve is provided with a protruding step. The locking sleeve is a ring with an L-shaped cross section, and the locking sleeve is provided with an inner thread. The outer thread of the end portion of the sleeve is matched with the inner thread of the lockingsleeve, and the locking sleeve is screwed to the end portion of the sleeve through the threads. The ring sleeves are two semicircular rings provided with grooves, and the shape of the grooves is matched with the protruding step on the sleeve. The grooves of the two ring sleeves are clamped to the step of the sleeve to form a complete ring. The fixing ring is a ring with an L-shaped cross sectionand is arranged on the sleeve in a sleeving manner, the diameter of an inner hole of the end face of the fixing ring is matched with the outer diameter of the sleeve, the inner diameter of the ring ismatched with the outer diameter of the ring sleeves, and the ring sleeves are fixed. By means of the demounting and mounting tool used for the fixed type inner magnetic steel of the corrugated spring, the corrugated spring is pressed by rotating the locking sleeve, and the problem that demounting and mounting cannot be conducted by labor is solved.

The invention discloses a biological activity bionic calcium phosphate nanometer material which is a nanometer calcium phosphate particle containing at least two elements of silicon, strontium, zinc and magnesium, the mass percent of components shown by an oxide mode is as follows: 40-55 percent of CaO, 38-44 percent of P2O5, 0-0.3 percent of SiO, 0-5.5 percent of SrO, 0-3.5 percent of ZnO, 0-4.5 percent of MgO and 3-8 percent of H2O, wherein the sum of the components is 100 percent, and the contents of at least two materials of SiO2, ZnO, MgO and SrO are not simultaneously 0. The preparation method comprises the steps of adding chain polymer solution containing side chain carboxyl in simulated body fluid, and adding inorganic salt solution containing at least two kinds of ions of silicon, strontium, zinc and magnesium, reacting and aging to analyze the nanometer calcium phosphate particle corporately doped with trace elements, filtering and washing, and drying to obtain the nanometer calcium phosphate particle. The nanometer material can continuously degrade and synchronously release calcium ions, phosphate radical ions and the trace elements in osseous tissues, and is suitable for the repair application of the bone teeth injure of a human body. The invention is simple in process, easy to control the nanometer appearance and size, the trace element composite proportion, and the like.