Slow releasing carrier material for implanted medicine and its preparation process

A slow-release carrier and drug technology, applied in medical science, surgery, etc., can solve the problems that do not involve changing the composition ratio of reactants, and does not involve the application of implantable drug controlled-release materials, and achieve good in vivo and in vitro biocompatibility effect of sex, availability, and good tissue response

Inactive Publication Date: 2009-09-16
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But all bibliographical reports all are limited to by single reactant sebacic acid and glycerin and generate polyglyceryl sebacate, do not involve changing the composition ratio of reactant, adjust its by filling different monomers and polymers Surface properties and degradation properties, not to mention the application as an implantable drug controlled release material

Method used

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  • Slow releasing carrier material for implanted medicine and its preparation process
  • Slow releasing carrier material for implanted medicine and its preparation process
  • Slow releasing carrier material for implanted medicine and its preparation process

Examples

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example 1

[0039] Example 1: Controlling the degradation rate by controlling the different ratios of reactants.

[0040] The reactants are sebacic acid and glycerin, the sebacic acid and glycerin are mixed in a ratio of 1:3 to 3:1 by weight, nitrogen gas is passed through, and a polycondensation reaction occurs at a temperature of 130 to 160°C to form a prepolymer. Then put the prepolymer into a container with a certain shape, and further synthesize the material with a certain shape formed by the reaction at a temperature of 120-140°C. By controlling the ratio of the two, drugs with different degradation rates can be implanted into sustained-release carrier materials. It can be used for local chemotherapy after patients with solid tumors to achieve the purpose of effectively killing residual malignant tumor cells. Different degradation speeds are required dosages for different drugs. Different ratios of reactants can result in different degradation rates. When the ratios of sebacic aci...

example 2

[0041] Example 2: Control of degradation rate by incorporation of glycolic acid monomer at different concentrations.

[0042] In order to control the high molecular weight and better viscoelasticity in the polymer synthesis process, different concentrations of glycolic acid monomers were put into the prepolymer stage to synthesize the drug implanted slow-release carrier material. When the ratio of sebacic acid and glycerol is 2:1, and the incorporation concentrations are 0.2, 0.4, 0.6, 1, the complete degradation periods are 40-60 days respectively.

example 3

[0043] Example 3: Controlling the degradation rate by incorporating different concentrations of lactic acid monomer.

[0044] In order to control the high molecular weight and better viscoelasticity in the polymer synthesis process, different concentrations of lactic acid monomers were put into the prepolymer stage to synthesize the drug implanted slow-release carrier material. When the ratio of sebacic acid and glycerin is 2:1, when the incorporation concentration is 0.2, 0.4, 0.6, 1, the complete degradation period is 50-80 days respectively.

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Abstract

The present invention provides one kind of slow releasing carrier material for implanted medicine. The slow releasing carrier material is prepared through mixing sebacic acid and glycerin in the weight ratio of 1 / 3 to 3 and polycondensation at 130-160 deg.c to produce prepolymer; mixing with certain amount of lactic acid, hydrolactic acid, polylactic acid or polyhydrolactic acid; setting the mixture in some shaping container and further synthesis reaction at 120-140 deg.c. It has certain degradation speed and shape. The present invention has the features of no negative effect of catalyst and solvent, excellent tissue reaction with less caused inflammation and fibrosis, no obvious degradation caused swelling, no in vitro macrophage toxicity, and capacity of maintaining the shape, surface integrity and mechanical strength during degradation.

Description

(1) Technical field [0001] The invention relates to a biodegradable material, in particular to a medical biodegradable material, especially a slow-release material of medicine. (2) Background technology [0002] The most widely used biodegradable materials in the field of biomedicine are polyglycolide, polylactide and their copolymers poly(DL-lactide-coglycolide), etc., and there is an initial mass in the degradation process. Rapid loss, loss of mechanical strength, swelling, significant deformation and other shortcomings. Its related reports are also many, such as disclosed in the invention patent document of patent application number 86104141, named as the preparation method of polyacrylate drug sustained release material technical solutions, etc. [0003] Poly(glycerol-sebacate), PGS elastomer, as a new type of biodegradable material, was synthesized for the first time in 2002 by the research group of Langer R, Massachusetts Institute of Technology. It has many advantag...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34A61K47/14A61L31/04C08G63/12
Inventor 孙志洁鲁玺丽董德利郑玉峰李莉乌兰
Owner HARBIN ENG UNIV
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