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Medicine coating carrier used for medicine coating blood vessel support and method for preparing the medicine coating blood vessel support

A drug coating and vascular stent technology, which is applied in stents, medical science, surgery, etc., can solve the problems of easy inflammatory reaction, degradation and shedding, and achieve the effect of less inflammation and fibrosis in vivo, not easy to fall off, and good tissue response.

Active Publication Date: 2009-12-09
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In order to solve the problem that the drug-coated carrier on the existing drug-coated vascular stent is prone to inflammatory reaction and easy to degrade and fall off during the degradation process, the present invention provides a drug-coated carrier for drug-coated vascular stent and Preparation method of drug-coated stent

Method used

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  • Medicine coating carrier used for medicine coating blood vessel support and method for preparing the medicine coating blood vessel support

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specific Embodiment approach 1

[0014] Embodiment 1: The drug-coated carrier for drug-coated vascular stent of this embodiment is prepared according to the following method: take 0.2-1 part of degradation regulator, 1-2.5 parts of sebacic acid and glycerol in molar ratio 0.8-1.2 parts are pre-polymerized under the condition of 130-160°C for 6-10 hours, then add 20%-50% of the total weight of sebacic acid and glycerin, and mix evenly to obtain the drug-coated blood vessel The drug coating carrier of the stent; the degradation regulator is glycolic acid, lactic acid, glycolide, lactide, chitin, polyglycolic acid, polylactic acid or chitosan.

specific Embodiment approach 2

[0015] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is: 0.4-0.8 parts of degradation regulator, 1.4-2 parts of sebacic acid and 0.9-1.1 parts of glycerin are taken at 140-150° C. Pre-polymerization under certain conditions for 7 to 9 hours. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0016] Embodiment 3: The difference between this embodiment and Embodiment 1 is: 0.6 parts of degradation modifier, 1.7 parts of sebacic acid and 1 part of glycerin are prepolymerized at 145°C for 8 hours in molar ratio. Other steps and parameters are the same as those in Embodiment 1.

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Abstract

The present invention relates to a preparation method of medicine coating carrier and medicine coating blood vessel scaffold. The preparation method of said medicine coating carrier includes the following steps: prepolymerization and mixing so as to obtain the medicine coating carrier, and the preparation method of said medicine coating blood vessel scaffold includes the following steps: (a), prepolymerization and mixing; and (b), polycondensation.

Description

technical field [0001] The invention relates to a preparation method of a drug coating and a drug support. Background technique [0002] The drug-coated carriers on the drug-coated stents currently developed include polylactic acid, polyglycolic acid, polypropylene oxide, and polyorthoesters. The main disadvantage of the drug-coated carrier is that additional catalysts and solvents need to be added during the synthesis process. , have a negative impact on biocompatibility, and are prone to inflammatory reactions, and the drug coating carrier is coated on the stent after synthesis, and the binding force with the stent is not strong. During the degradation and release of the drug, the drug coating is prone to large Area detachment, especially as a coronary stent, brings danger to the life of the patient. Contents of the invention [0003] In order to solve the problem that the drug-coated carrier on the existing drug-coated vascular stent is prone to inflammatory reaction a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/16A61L31/06A61F2/82
Inventor 董德利孙志洁鲁玺丽杨宝峰
Owner HARBIN MEDICAL UNIVERSITY
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