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Spinning solution, nuclear shell nanofiber as well as preparation method and application thereof

A technology of nanofibers and spinning solutions, which can be used in rayon manufacturing, fiber chemical characteristics, textiles and papermaking, etc., and can solve problems such as high prices

Inactive Publication Date: 2015-02-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The degradation of PPDO is mainly caused by the hydrolysis of the acetic acid bond on its molecular chain, and its degradation products are consistent with human metabolites, most of which are excreted from the respiratory tract, and a small amount is excreted from urine and feces, so it has excellent biocompatibility in the organism In addition to biodegradability and biodegradability, it has been successfully applied to the manufacture of surgical sutures, bone plates and tissue repair materials, such as the surgical sutures (trade name PDS) sold by Ethiocn in the United States, but the price is very expensive

Method used

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  • Spinning solution, nuclear shell nanofiber as well as preparation method and application thereof
  • Spinning solution, nuclear shell nanofiber as well as preparation method and application thereof
  • Spinning solution, nuclear shell nanofiber as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] Weigh a certain amount of polyvinyl alcohol (PVA, average polymerization degree 1700, alcoholysis degree 88%) according to the formula and dissolve it in a certain volume of distilled water. The concentration of PVA is 4%wt / v (ie 0.04g / ml), Heat and stir at 80°C for 12 hours, while weighing a certain amount of polyethylene glycol-b-poly(p-dioxanone) (PEG-b-PPDO, or PEDO) of three different molecular weights. Its molecular structure is diblock. The weight average molecular weights are 9764, 3837 and 2716, respectively. The mass ratios of hydrophilic block PEG and lipophilic block PPDO are respectively 1:4, 1:0.9 and 1:0.7) respectively dissolved in a certain volume of distilled water to obtain three A PEDO solution and the concentration of the three PEDO solutions are 1%wt / v (ie 0.01g / ml), heated and stirred at 30 ℃ for 2h, and then the above PVA solution and each PEDO solution (ie PVA solution and three Any one of the PEDO solutions in the PEDO solution) are mixed to obt...

Embodiment 2

[0104] Weigh a certain amount of polyvinyl alcohol (PVA, average polymerization degree 1700, alcoholysis degree 88%) according to the formula and dissolve it in a certain volume of distilled water. The concentration of PVA is 4%wt / v (ie 0.04g / ml), Heat and stir at 80℃ for 12h, and weigh a certain amount of polyethylene glycol-b-poly(p-dioxanone) (PEG-b-PPDO, PEDO) with three different molecular structures. The weight-average molecular weights of tri-block and multi-block are 3837, 5670 and 15000, respectively. The mass ratios of hydrophilic block PEG and lipophilic block PPDO are 1:0.9, 1:1.8 and 1:6.5) respectively. A certain volume of distilled water in order to obtain three PEDO solutions and the concentration of the three PEDO solutions is 5%wt / v (ie 0.05g / ml), heated and stirred at 30℃ for 2h, and then the above PVA solution and each PEDO solution (That is, the PVA solution and any one of the three PEDO solutions) are mixed to obtain three spinning solutions respectively. ...

Embodiment 3

[0106] Weigh a certain amount of polyvinyl alcohol (PVA, average polymerization degree 1700, alcoholysis degree 66%) according to the formula and dissolve it in a certain volume of distilled water. The concentration of PVA is 4%wt / v (ie 0.04g / ml), Heat and stir at 80°C for 12 hours, while weighing a certain amount of polyethylene glycol-b-poly(p-dioxanone) (PEG-b-PPDO, or PEDO) of three different molecular weights. Its molecular structure is diblock. The weight-average molecular weights are 9764, 3837 and 2716, respectively. The mass ratios of hydrophilic block PEG and lipophilic block PPDO are 1:3.8, 1:0.9 and 1:0.35), respectively, dissolved in a certain volume of distilled water to obtain three A PEDO solution and the concentration of the three PEDO solutions are all 10%wt / v (ie 0.1g / ml), heated and stirred at 30 ℃ for 2h, and then the above PVA solution and each PEDO solution (ie PVA solution and three Any one of the PEDO solutions in the PEDO solution) are mixed to obtain ...

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Abstract

The invention discloses a spinning solution, nuclear shell nanofiber as well as a preparation method and application thereof. A hydrophobic drug and polyvinyl alcohol (PVA) / polyethylene glycol-b-poly(p-dioxanone) (PEG-b-PPDO) are blended to obtain a spinning solution system, and the nuclear shell nanofiber is directly formed by utilizing a single-axis spinneret under a high-voltage electrostatic effect. The preparation method disclosed by the invention has the advantages of simple equipment, mild conditions, simple flow and low energy consumption, can be used for achieving the aims of high-efficiency embedding of the hydrophobic drug, controllable drug release speed and long sustained release time, and is very suitable for industrial production.

Description

Technical field [0001] The invention relates to a core-shell nanofiber and the preparation of a hydrophobic drug long-acting sustained-release preparation based on the material. More specifically, the present invention relates to a spinning solution containing polyvinyl alcohol (PVA) / polyethylene glycol-b-poly-p-dioxanone (PEG-b-PPDO), a core optionally containing a hydrophobic drug Shell nanofiber and its preparation method and use. Background technique [0002] The development of new pharmaceutical excipients and the promotion of formulation optimization is one of the current strategic tasks for the development of Chinese traditional medicine in line with international standards. At present, sustained-release agents are classified according to the selected materials and methods, mainly including matrix sustained-release, film-coated sustained-release, biological adhesive sustained-release and microsphere sustained-release. At the same time, the use of a slow-release agent car...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F8/10D01F8/16D01F1/10A61K47/34A61K47/32A61K45/00
Inventor 刘娅翟飞玉陈思翀王玉忠秦青敬新柯黄维郭德明
Owner SICHUAN UNIV
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