Biological activity bionic calcium phosphate nanometer material as well as preparation method and purpose thereof

A bioactive, nanomaterial technology, applied in the field of biomimetic calcium phosphate nanomaterials and their preparation, can solve the problems that have not yet been involved, and achieve the effects of easy control of doping rate, promotion of bone regeneration biological activity, and simple process

Inactive Publication Date: 2012-07-11
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there is no patented technology or experimental report involving the biomimetic mineralization synthesis and application of silicon, strontium, zinc or / and magnesium synergistically doped bone-like calcium phosphate materials

Method used

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  • Biological activity bionic calcium phosphate nanometer material as well as preparation method and purpose thereof
  • Biological activity bionic calcium phosphate nanometer material as well as preparation method and purpose thereof
  • Biological activity bionic calcium phosphate nanometer material as well as preparation method and purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1) will contain Na + , 142mM; K + , 5mM; Ca 2+ , 2.5mM; Mg 2+ , 1.5mM; SO 4 2- , 1mM; HPO 4 2- , 1mM; Cl - , 36mM and HCO 3 - , 2.0L simulated body fluid (SBF) of 14mM was equally divided into three 2.5L volume clean strain bottles, and marked as A, B and C respectively, and polyaspartic acid was added to the above SBF solution under stirring conditions solution, Na 2 SiO 3 , MgCl 2 , ZnCl 2 and / or SrCl 2 Solution, wherein, A bottle Zn: Ca molar ratio is 0.4: 100; newly added Mg 2+ Ions and Ca in SBF 2+ The ion molar ratio Mg:Ca is 0.2:100; the molar ratios of Zn:Ca and Sr:Ca in bottle B are 0.4:100 and 6:100 respectively; the newly added Mg 2+ Ions and Ca in SBF 2+ The ion molar ratio Mg:Ca is 0.8:100; the C bottle Si:P, Zn:Ca and Sr:Ca molar ratios are 6:100, 0.8:100 and 3:100 respectively; the newly added Mg 2+ Ions and Ca in SBF 2+ The ion molar ratio Mg:Ca was 0.2:100; and the concentrations of polyaspartic acid (PAsp) in the three bottles of sol...

Embodiment 2

[0042] The preparation method is the same as in Example 1, the difference is that: add MgCl-containing 2 and ZnCl 2 solution, the newly added Mg 2+ Ions and Ca in SBF 2+ The ratio of ions Mg:Ca is 0.4:100, but the molar ratio of Zn:Ca is 0.8:100, 1.2:100 and 2:100 in sequence, the concentration of polyacrylic acid (PAA) in the three bottles of solution is controlled to be 5 μM, and the aging temperature is 90°C , the aging time is 5 minutes. The content of Mg and Zn in nanoparticles is as follows Figure 5 As shown, as the concentration of Zn ions in the SBF solution increases, the zinc content in the nanoparticles also gradually increases, indicating that the doping rate can be increased by increasing the concentration of trace elements in the biomimetic synthesis of binary trace elements synergistic doping.

Embodiment 3

[0044] The preparation method is the same as in Example 1, the difference is that: add MgCl-containing 2 , SrCl 2 and ZnCl 2 solution, the newly added Mg 2+ Ions and Ca in SBF 2+ The ratio of ions Mg: Ca is 0.4: 100, and the molar ratio of Zn: Ca is 0.4: 100, but the molar ratio of Sr: Ca is 3: 100, 6: 100 and 10: 100 in turn. Control the sodium polyacrylate in the three bottles of solution (PAAS) concentration was 1.0 μM; aging temperature was 150°C, and the contents of Sr, Mg and Zn in nanoparticles after aging for 90 minutes were as follows: Figure 6 As shown, as the concentration of Sr ions in the SBF solution increases, the content of strontium in the nanoparticles also gradually increases, indicating that the doping rate can be increased by increasing the concentration of trace elements in the biomimetic synthesis of synergistic doping of ternary trace elements.

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Abstract

The invention discloses a biological activity bionic calcium phosphate nanometer material which is a nanometer calcium phosphate particle containing at least two elements of silicon, strontium, zinc and magnesium, the mass percent of components shown by an oxide mode is as follows: 40-55 percent of CaO, 38-44 percent of P2O5, 0-0.3 percent of SiO, 0-5.5 percent of SrO, 0-3.5 percent of ZnO, 0-4.5 percent of MgO and 3-8 percent of H2O, wherein the sum of the components is 100 percent, and the contents of at least two materials of SiO2, ZnO, MgO and SrO are not simultaneously 0. The preparation method comprises the steps of adding chain polymer solution containing side chain carboxyl in simulated body fluid, and adding inorganic salt solution containing at least two kinds of ions of silicon, strontium, zinc and magnesium, reacting and aging to analyze the nanometer calcium phosphate particle corporately doped with trace elements, filtering and washing, and drying to obtain the nanometer calcium phosphate particle. The nanometer material can continuously degrade and synchronously release calcium ions, phosphate radical ions and the trace elements in osseous tissues, and is suitable for the repair application of the bone teeth injure of a human body. The invention is simple in process, easy to control the nanometer appearance and size, the trace element composite proportion, and the like.

Description

technical field [0001] The invention relates to a biomimetic calcium phosphate nanomaterial containing at least two trace elements and capable of significantly promoting the regeneration and repair of bone and tooth damage, its preparation method and application, and belongs to the technical field of biomedical materials. Background technique [0002] Osteoporosis in the middle-aged and elderly people causes significant bone mass decline and bone injury complications such as fractures; secondly, other diseases (such as bone tumors), surgery (such as craniotomy) and mechanical injuries (such as work-related injuries, traffic accidents) etc. The rapid and complete regenerative repair of bone and tooth defects is a difficult problem in current clinical medicine. At present, by CaO, SiO 2 ,P 2 o 5 and Na 2 Glass powder material composed of O (trade name: 45S5 Bioglass ) has excellent biological activity, can induce bone-like apatite deposition and form bone chemical bonds ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12C01B25/32A61K6/033A61K6/838
Inventor 苟中入高欣
Owner ZHEJIANG UNIV
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