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Sandwich layer slow-release birth control material

A sandwich layer, slow-release technology, applied in the field of medical materials, can solve the problems of breakage and falling off of IUDs, serious copper ion release phenomenon, uncontrollable copper ion release speed, etc., and achieve the effect of controllable release speed.

Inactive Publication Date: 2010-04-21
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The release of copper ions from metal copper IUDs mainly has the following three problems: First, the initial violent release of copper ions is serious
Third, the release rate of copper ions in the metal copper IUD is uncontrollable, and the part that is in sufficient contact with oxygen and water will corrode quickly, which will easily cause the IUD to break and fall off

Method used

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  • Sandwich layer slow-release birth control material
  • Sandwich layer slow-release birth control material
  • Sandwich layer slow-release birth control material

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0031] Upper surface layer: Weigh 5g polyvinyl alcohol (referred to as PVA, the same below), add 2.14g SiO 2 , Add distilled water to 100g, stir at 90°C for 1 hour to obtain uniform PVA / SiO 2 The solution was cast into a film on a smooth and flat 20cm×30cm glass plate.

[0032] Intermediate layer: Weigh 5g PVA, add 2.14g SiO 2 , Add distilled water to 100g, stir at 90°C for 1 hour to obtain uniform PVA / SiO 2 The solution was cooled to 40° C., 4.76 g of copper chloride was added, and stirred for 0.5 hours to obtain a uniform membrane liquid. Cast film on the above-mentioned dried film.

[0033] Lower surface layer: prepare the same PVA / SiO according to the method of preparing the upper surface layer 2 Solution. Cast film on the above-mentioned dried film.

[0034] After drying, take it off and immerse it in a simulated human body fluid to measure the release of copper ions. Such as figure 1 Curve a in the middle, namely 30% SiO 2 / PVA, 30% SiO 2 / 40%CuCl 2 / PVA, 30% SiO 2 / PVA.

example 2

[0036] Upper surface layer: Weigh 5g PVA and add 2.14g SiO 2 , Add distilled water to 100g, stir at 90°C for 1 hour to obtain uniform PVA / SiO 2 The solution was cast into a film on a smooth and flat 20cm×30cm glass plate.

[0037] Intermediate layer: Weigh 5g PVA and add 3.33g SiO 2 , Add distilled water to 100g, stir at 90°C for 1 hour to obtain uniform PVA / SiO 2 The solution was cooled to 40° C., 5.55 g of copper chloride was added, and stirred for 0.5 hours to obtain a uniform membrane liquid. Cast film on the above-mentioned dried film.

[0038] Lower surface layer: prepare the same PVA / SiO according to the method of preparing the upper surface layer 2 Solution. Cast film on the above-mentioned dried film.

[0039] After drying, take it off and immerse it in a simulated human body fluid to measure the release of copper ions. Such as figure 1 Curve b in the middle, which is 30% SiO 2 / PVA, 40% SiO 2 / 40%CuCl 2 / PVA, 30% SiO 2 / PVA. figure 1 The surface layer composition of mid...

example 3

[0041] Upper surface layer: Weigh 5g PVA, add 3.33g SiO 2 , Add distilled water to 100g, stir at 90°C for 1 hour to obtain uniform PVA / SiO 2 The solution was cast into a film on a smooth and flat 20cm×30cm glass plate.

[0042] Intermediate layer: Weigh 5g PVA, add 2.14g SiO 2 , Add distilled water to 100g, stir at 90°C for 1 hour to obtain uniform PVA / SiO 2 The solution was cooled to 40° C., 4.76 g of copper chloride was added, and stirred for 0.5 hours to obtain a uniform membrane liquid. Cast film on the above-mentioned dried film.

[0043] Lower surface layer: prepare the same PVA / SiO according to the method of preparing the upper surface layer 2 Solution. Cast film on the above-mentioned dried film.

[0044] After drying, take it off and immerse it in a simulated human body fluid to measure the release of copper ions. Such as figure 1 Curve c in the middle, which is 40% SiO 2 / PVA, 30% SiO 2 / 40%CuCl 2 / PVA, 40% SiO 2 / PVA. figure 1 The composition of the middle layer of the...

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Abstract

The invention discloses a sandwich layer slow-release birth control material, which is formed by superposing hybrid material layers and complexing polymer-matrix composite material layers in a staggered mode, and the bottom layer and the top layer are the hybrid material layers consisting of polyving akohol and 10 to 40 weight percent of SiO2; the complexing polymer-matrix composite material layers consist of the polyving akohol, 10 and 40 weight percent of SiO2 and 10 and 40 weight percent of copper salt. The sandwich layer slow-release birth control material can release copper ions slowly, reduces the phenomenon of the burst release of the copper ions caused by the conventional metal copper birth-control device and the nanometer copper / low-density polyethylene birth-control device, andeliminate side effects such as massive hemorrhage, underbelly pain, pelvic inflammatory disease and the like caused by the burst release of the copper ions during initial implantation. The release process comprises that the copper ions dissociated in an intermediate layer of a composite material are diffused towards a surface layer under the action of concentration gradient; the copper ions diffused to the surface layer are diffused to an interface where the material is contacted with body fluid of a human body; and finally, the copper ions are diffused to the body fluid of the human body through the interface. The sandwich layer slow-release birth control material prolongs a path for diffusing medicaments, increases the resistance of medicament release, and slows down the release speed of the copper ions.

Description

Technical field [0001] The invention belongs to the technical field of medical materials, and specifically relates to a controlled and sustained-release birth control material. technical background [0002] The population problem is related to people's livelihood and is a major issue affecting economic and social development. In the past 30 years, my country’s economic and social development has made world-renowned achievements, the people’s living standards have improved significantly, and the population structure and quality have undergone profound changes. Family planning work has made important contributions to scientific development. Improving the people's reproductive health has become an important part of improving the quality and level of population and family planning work under the new historical conditions. Among them, the intrauterine device (IUD) is a safe, effective, economical, and convenient contraceptive tool, and it is also one of the most widely used birth co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/16
Inventor 李娟索进平
Owner HUAZHONG UNIV OF SCI & TECH
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