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Calcium alginate porous membrane containing metal ion-carrying zirconium phosphate and preparation method of calcium alginate porous membrane

A metal ion, calcium alginate technology, applied in medical science, bandages, absorbent pads, etc., to achieve low manufacturing cost, simple preparation technology, and avoid rapid release and discoloration

Inactive Publication Date: 2018-07-20
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the defects of current calcium alginate and silver-loaded calcium alginate wound dressings, the present invention proposes to combine metal-ion-loaded zirconium phosphate with calcium alginate to develop a calcium alginate porous membrane containing metal-ion-loaded zirconium phosphate for various wound dressings. Management of skin wounds due to disease

Method used

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  • Calcium alginate porous membrane containing metal ion-carrying zirconium phosphate and preparation method of calcium alginate porous membrane
  • Calcium alginate porous membrane containing metal ion-carrying zirconium phosphate and preparation method of calcium alginate porous membrane

Examples

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Effect test

Embodiment 1

[0024] Example 1 Preparation of calcium alginate porous membrane containing zirconium phosphate loaded with metal ions

[0025] A) 1.0 grams of silver-loaded zirconium phosphate with a silver / zirconium molar ratio of 0.05 were dispersed into 100 grams of pH 7 containing 2 wt% sodium alginate aqueous solution under mechanical stirring;

[0026] B) Spread the obtained sodium alginate aqueous solution containing silver-loaded zirconium phosphate into a film, then solidify it with an aqueous solution containing 1mol / L calcium chloride for 12 hours and rinse it repeatedly with deionized water to obtain calcium alginate containing silver-loaded zirconium phosphate Hydrogel film;

[0027] C) Freeze-drying the calcium alginate hydrogel membrane containing silver-loaded zirconium phosphate to finally obtain a calcium alginate porous membrane containing metal ion-loaded zirconium phosphate. Wherein, the weight ratio of silver-loaded silver zirconium phosphate to calcium alginate is 50%...

Embodiment 2

[0028] Example 2 Preparation of calcium alginate porous membrane containing zirconium phosphate loaded with metal ions

[0029] Using 1.0 g of silver-loaded zirconium phosphate with a silver / zirconium molar ratio of 0.1, other preparation conditions were the same as in Example 1 to obtain a calcium alginate porous membrane containing silver zirconium phosphate with a silver / zirconium molar ratio of 0.1. Wherein, the weight ratio of silver-loaded zirconium phosphate to calcium alginate is 50%, and the average pore diameter is 100 microns.

Embodiment 3

[0030] Example 3 Preparation of calcium alginate porous membrane containing zirconium phosphate loaded with metal ions

[0031] Using 0.1 g of silver-loaded zirconium phosphate with a silver / zirconium molar ratio of 0.1, other preparation conditions were the same as in Example 1 to obtain a calcium alginate porous membrane containing silver-loaded zirconium phosphate with a silver / zirconium molar ratio of 0.1. Wherein, the weight ratio of silver-loaded zirconium phosphate to calcium alginate is 5%, and the average pore size is 150 microns.

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Abstract

The invention relates to a calcium alginate porous membrane containing metal ion-carrying zirconium phosphate and a preparation method of the calcium alginate porous membrane, and belongs to the fieldof biomedical materials. The calcium alginate porous membrane containing metal ion-carrying zirconium phosphate is characterized in that the matrix material of the porous membrane is composed of calcium alginate, and metal ion-carrying zirconium phosphate is uniformly dispersed in the calcium alginate matrix. Functional metal ion-carrying zirconium phosphate is added on the basis of calcium alginate, so that the calcium alginate porous membrane has better biomedical performance than that of pure calcium alginate as wound dressing, and can replace the pure calcium alginate dressing to be applied to management of skin wounds caused by various diseases accordingly. The preparation technology is simple, the manufacturing cost is relatively low, and large-scale production can be realized.

Description

technical field [0001] The invention relates to a calcium alginate porous membrane, in particular to a calcium alginate porous membrane containing metal ion-loaded zirconium phosphate, a preparation method thereof, and an application in skin wound management, belonging to the field of biomedical materials. Background technique [0002] The use of wound dressings to manage wounds caused by various reasons has become an important means in clinical practice, and clinical practice has widely confirmed that the performance of wound dressings will affect wound healing. For this reason, the research and development has multifunctional, can promote wound healing dressing and become the target that people pursue all the time. At present, various functional wound dressings have been developed, including collagen, calcium alginate, various hydrogels, silver-loaded carbon porous membrane cloth, etc. Among these dressings, calcium alginate porous membrane is currently one of the most wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/42A61L15/46A61L15/44
CPCA61L15/18A61L15/28A61L15/425A61L15/44A61L15/46A61L2300/104A61L2300/404A61L2300/412A61L2300/418A61L2300/602C08L5/04
Inventor 洪友良周钲人武祯
Owner SICHUAN UNIV
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