Absorbable hemostatic ligating clip and preparation method thereof

Abstract

The invention discloses an absorbable hemostatic ligating clip and a preparation method thereof. The absorbable hemostatic ligating clip is prepared from the following material components in parts by weight: 5 to 70 parts of polyglycolic acid composite particles and 30 to 95 parts of polyethylene glycol modified poly(p-dioxanone), wherein the polyglycolic acid composite particles consist of polyglycolic acid and cell factors according to the weight ratio of (40-45):1; the cell factors are blood coagulation factors or growth factors. According to the absorbable hemostatic ligating clip disclosed by the invention, the polyglycolic acid composite particles can be quickly decomposed in the early stage by adjusting the molecular weight and the use amount of polyglycolic acid, to assist damaged tissues in hemostasis or recovery; furthermore, the structure of the ligating clip is complete within two weeks to achieve an effective closing effect; after two weeks, the polyglycolic acid is gradually completely degraded, and then the cell factors are completely released, so that the ligating clip can be decomposed quickly within 2 to 4 weeks and fall off and is completely absorbed within 4 months; therefore, the clinical requirement is met, and the postoperative potential risk is reduced. The preparation method of the absorbable hemostatic ligating clip has simple technological conditions, the operation is easy, the requirement on equipment is low, and the absorbable hemostatic ligating clip and the preparation method thereof are suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to the technical field, in particular to an absorbable hemostatic ligation clip and a preparation method thereof. Background technique [0002] Clinically used hemostatic ligation clips include metal titanium clips and absorbable ligation clips. Metal titanium clips are non-absorbable, and the metal material is too rigid, causing great damage to vascular tissue. Excessive clipping can cause blood vessel cutting; Disadvantages such as easy interference and potential danger caused by permanent foreign bodies in the body are gradually replaced by absorbable hemostatic ligation clips; currently on the market absorbable hemostatic ligation clips include Anshu Suppository of Johnson & Johnson TM Absorbable Bio-Clip and Tyco's Lapro-Clip TM Absorbable ligation clips, such as "Sufeng" brand absorbable hemostatic ligation clips registered by Hangzhou Shengshi Company in China, are mostly made of polydioxanone (PPDO) or amino acid modified...

AI Technical Summary

Problems solved by technology

However, there are also the following disadvantages: the degradation rate is slow, the ligation clip loses its strength, it takes 1-2 months to fall off, and it takes more than 6 months to completely absorb it. Since the clinical closure time of blood vessels and other tubular tissues is only 1-2 weeks, the ligation clip Long-term placement at the ligation site has potential risks. In addition, blood vessels or other tissues may still be damaged and bleeding, which is not conducive to the recovery of patients

[0003] Amino acid-modified polydioxanone materials contain a lot of amino and carboxyl groups, so the amino acid content is too small to play a hydrophilic role, and if the content is high, it is difficult to obtain polymers with higher molecular weight or viscosity after copolymerization. Material mechanics Poor performance, unable to meet the clinical needs of ligation clip products