Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicinal gullet scaffold fiber and preparation method thereof

A technology of fiber and esophagus, applied in the field of medical esophageal stent fiber and its manufacture, medical esophageal stent fiber and its preparation, can solve the problems of poor toughness and biodegradability, unseen problems, etc., and achieve good biodegradability, The effect of high mechanical support strength and ensuring stability

Inactive Publication Date: 2011-05-25
DONGHUA UNIV +1
View PDF3 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of polydioxanone in esophageal stent has not been seen yet.
In addition, it is known that more than 80% of the materials used in esophageal stents are metals, while the other 20% of the materials have poor toughness and biodegradability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal gullet scaffold fiber and preparation method thereof
  • Medicinal gullet scaffold fiber and preparation method thereof
  • Medicinal gullet scaffold fiber and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of preparation method of medical esophageal stent fiber of the present invention comprises the steps:

[0027] PPDO slices→drying→screw extrusion and ejection→cooling liquid cooling→stretching→winding→PPDO fiber

[0028] The specific process is as follows:

[0029] The polydioxanone chips are first dried at 70°C and have a moisture content of 29ppm, and are melted and extruded into the spinning box by twin-screws for spinning, and the spinning temperature is 135°C; then extruded through the spinneret The polydioxanone monofilament enters the cooling tank for cooling and solidification molding, the cooling liquid is 1,2-propylene glycol and absolute ethanol, the mass ratio of the two is 3:1, and the temperature is 35 °C; then use absolute ethanol The cooled and solidified polydioxanone fiber is cleaned, and the temperature is controlled at 30°C; then the obtained fiber is stretched on a hot plate, the stretching temperature is 60°C, and the one-time stretching ra...

Embodiment 2

[0033] This fiber preparation method comprises the steps:

[0034] PPDO slicing→drying→screw extrusion and spraying→cooling liquid cooling→stretching→winding→PPDO fiber The specific process is as follows:

[0035] The polydioxanone chips are first dried at 75°C, and the moisture content is 26ppm. They are melted and extruded into the spinning box for spinning by twin-screw, and the spinning temperature is 145°C; then extruded through the spinneret The polydioxanone monofilament enters the cooling tank for cooling and solidification molding, the cooling liquid is 1,2-propylene glycol and absolute ethanol, the mass ratio of the two is 3.5:1, and the temperature is 38 °C; then use absolute ethanol The cooled and solidified polydioxanone fiber is cleaned, and the temperature is controlled at 35°C; then the obtained fiber is stretched on a hot plate at a stretching temperature of 70°C, and the one-time stretching ratio is 5 times; Winding after shaping, the heat setting temperatur...

Embodiment 3

[0039] This fiber preparation method comprises the steps:

[0040] PPDO slicing→drying→screw extrusion and spraying→cooling liquid cooling→stretching→winding→PPDO fiber The specific process is as follows:

[0041] The polydioxanone chips are first dried at 80°C and have a moisture content of 27ppm. They are melted and extruded into the spinning box by twin-screws for spinning, and the spinning temperature is 155°C; then extruded through the spinneret The polydioxanone monofilament enters the cooling tank for cooling and solidification molding, the cooling liquid is 1,2-propylene glycol and absolute ethanol, the mass ratio of the two is 4:1, and the temperature is 40 °C; then use absolute ethanol The cooled and solidified polydioxanone fiber is cleaned, and the temperature is controlled at 38°C; then the obtained fiber is stretched on a hot plate, the stretching temperature is 75°C, and the one-time stretching ratio is 8 times; Winding after shaping, the heat setting temperatu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
glass transition temperatureaaaaaaaaaa
melting pointaaaaaaaaaa
Login to View More

Abstract

The invention relates to a medicinal gullet scaffold fiber capable of being absorbed by a human body and a manufacturing method thereof. A poly(p-dioxanone) (PPDO) fiber in accordance with the requirements is prepared by melt spinning. The method comprises the following preparation processes of: drying PPDO slices at the temperature of between 70 and 80 DEG C, and spinning the dried PPDO slices in a spinning beam by screw extrusion, wherein the spinning temperature is between 135 and 160 DEG C; extruding through a spinneret plate, and then cooling, curing and molding in a cooling tank, wherein the cooling solution contains 1,2-propylene glycol and absolute ethanol, the mass ratio of the 1,2-propylene glycol to the absolute ethanol is 3-5:1, and the temperature is between 35 and 40 DEG C; then cleaning the PPDO fiber by using the anhydrous ethanol, and controlling the temperature to be between 30 and 40 DEG C; performing hot plate drawing on the obtained fiber by 2 to 10 times, whereinthe drawing temperature is between 60 and 80 DEG C; and performing heat setting at the temperature of between 60 and 90 DEG C, and coiling. The fiber prepared by the method has good uniformity; the stability of the PPDO fiber during processing is ensured; and the fiber has no toxicity or stimulus, and has high mechanical support strength and good biodegradability, biocompatibility and machinability.

Description

technical field [0001] The present invention relates to a kind of biological material fiber and its manufacturing method, especially to a kind of medical esophagus stent fiber and its preparation method, specifically a kind of polydioxanone (PPDO) which can be absorbed by human body Medical esophageal stent fiber and its manufacturing method. Background technique [0002] The production of esophageal stents is the product of continuous exploration in the treatment of esophageal cancer. In 1983, Frimberger first reported the success of metal stents in the treatment of esophageal stenosis, creating a new era of stent treatment for esophageal cancer and providing a new idea for the treatment of esophageal stenosis. In 1991, Songetal of South Korea coated the metal esophageal stent with a silicone film, and the application of the stent became more and more widespread. Now the stent has been widely used in benign and malignant esophageal strictures, esophageal fistula repair and...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/62D01D5/088A61L31/06A61L31/14
Inventor 李文刚王大新张秀芳宋月华胡俊张军陈大钟张幼维赵炯心陈南梁
Owner DONGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com