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A preparation method of drug-loaded polylactic acid surgical suture

A technology of surgical suture and polylactic acid, which is applied in surgery, pharmaceutical formulation, drug delivery, etc., can solve the problems of low drug load and difficult drug release, and achieve good drug sustained release function, good dispersibility, and dispersibility stable effect

Active Publication Date: 2019-04-16
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, some people have prepared polylactic acid surgical sutures with certain antibacterial effects by adding antibacterial agents in the spinning process, but the drug loading is low and the problem of sudden drug release is serious, so it is difficult to achieve the expected effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] The present invention is further illustrated by the following examples, but not limited to the following examples.

[0012] Step 1. Preparation of drug-loaded microspheres

[0013] Take 20mL of dichloromethane and put 0.8g of polylactic acid particles into a flask, place the flask on a magnetic stirrer and adjust the rotation speed to 800r / min to form a polylactic acid solution.

[0014] Adjust the rotating speed of the magnetic stirrer to 1200r / min, slowly and evenly inject 3mL of gentamicin sulfate into the high-speed stirring polylactic acid solution with a syringe, and stir at high speed for 10min to form colostrum.

[0015] Take 1.5g of gelatin and 0.3g of polyoxyethylene sorbitan monooleate into a 500mL three-necked bottle, measure and add 400mL of deionized water, place the three-necked bottle on a magnetic stirrer and stir at a high speed of 1000r / min, Until all substances are completely dissolved, use as the outer aqueous phase.

[0016] Slowly inject the col...

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Abstract

The invention relates to a polylactic acid surgery suture line, in particular to a preparation method of a drug-loaded polylactic acid surgery suture line. The preparation method has the advantages that polylactic acid drug-loaded microspheres are loaded to the polylactic acid surgery suture line by turbid liquid made from starch acetate, polyethylene glycol and olive oil, and the turbid liquid has stable dispersity and is poisonless and harmless; the obtained drug-loaded surgery suture line does not have or seldom has burst drug release effect, and has a good slow drug release function; effective drug concentration can last for 50 days, and various mechanical properties of the processed surgery suture line are hardly damaged.

Description

technical field [0001] The invention relates to a polylactic acid surgical suture, in particular to a preparation method of a drug-loaded polylactic acid surgical suture. Background technique [0002] Polylactic acid fiber, also known as corn fiber, is made from corn and other grain raw materials through fermentation, polymerization, and spinning. Its crystallinity, transparency and heat resistance are similar to polyester fibers. Polylactic acid fibers and their copolymers have good biocompatibility and biodegradability, and can be gradually degraded into carbon dioxide and water in the human body, and are non-toxic and non-accumulative to the human body. At the same time, polylactic acid fiber also has considerable mechanical strength, durability and good processing performance. The fiber made of it has high tensile strength and good softness. It is a good absorbable suture material. [0003] Polylactic acid can easily carry bacteria in the fiber gaps of surgical sutures ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/14A61L17/12A61L17/00
CPCA61L17/005A61L17/12A61L17/145A61L2300/232A61L2300/404A61L2300/622A61L2400/12
Inventor 刘淑强吴改红张晓芳王妮许安郭红霞邵芬娟卢建军
Owner TAIYUAN UNIV OF TECH
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