A stable method for microencapsulating carotenoid

A carotenoid, stable technology, applied in the field of carotenoid granule or powder preparation, can solve the problems of carotenoid loss, affect the effective absorption of animals, waste of temperature and energy, etc., achieve good water dispersibility, significant coloring effect, extremely easily dispersed effect

Active Publication Date: 2013-09-25
肇庆巨元生化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The disadvantage of the above method is that the temperature in the process conditions is high, and because carotenoids are extremely unstable at high temperatures, they are prone to decomposition or isomerization, which causes the loss of carotenoids and affects the effective absorption of animals.
And the particle size of the emulsion carotenoid prepared by these methods is larger
In addition, the higher temperature also causes a waste of energy

Method used

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  • A stable method for microencapsulating carotenoid
  • A stable method for microencapsulating carotenoid
  • A stable method for microencapsulating carotenoid

Examples

Experimental program
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Effect test

specific Embodiment 1

[0036] A kind of microencapsulation method of stable carotenoid is carried out according to the following steps:

[0037] 1. Completely dissolve 33.5g gelatin, 43.3g sucrose, 1.5g Vc palmitate and 0.2g EDTA into 100.0g water to form a uniform water phase A, and adjust the pH to 10.0-10.5 with 20% NaOH solution.

[0038] 2. Dissolve 18.0 g of canthaxanthin crystals, 3.0 g of ethoxyquin, and 0.5 g of VE oil in 360.0 g of dichloromethane, stir until completely dissolved, and obtain oil phase B.

[0039] 3. Under high stirring and high shear conditions, add oil phase B to water phase A, then emulsify at a stirring speed of 2900-18000rpm for 15 minutes, then raise the temperature to 50°C to remove the solvent and form a microemulsion. Wherein, the obtained microemulsion is a sub-nanometer microemulsion, its average particle diameter is 130-200nm, and the pH of the microemulsion is 9-10; high stirring and high shearing refers to: the shearing power is 0.5-100Kw, stirring The speed ...

specific Embodiment 2

[0045] 1. Dissolve 33.5g of gelatin, 51.g of sucrose, 1.5g of Vc palmitate, and 0.2g of EDTA into 100.0g of water to form a uniform water phase. Adjust the pH to 10.0-10.5 with 20% NaOH solution.

[0046] 2. Dissolve 10.5g of β-carotene crystals, 1.0g of BHT, and 2.0g of VE oil in 210.0g of chloroform, and stir until completely dissolved.

[0047] 3. Under high stirring and high shear conditions, add oil phase B to water phase A, then emulsify at a stirring speed of 2900-18000rpm for 15 minutes, then raise the temperature to 50°C to remove the solvent and form a microemulsion. Wherein, the obtained microemulsion is a sub-nanometer microemulsion, its average particle diameter is 130-200nm, and the pH of the microemulsion is 9-10; high stirring and high shearing refers to: the shearing power is 0.5-100Kw, stirring The speed is 2900-18000 rpm.

[0048] 4. Spray-dry the microemulsion to make β-carotene particles.

[0049] Refer to Table 2 and figure 2 , in the β-carotene granu...

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Abstract

The invention discloses a stable method for microencapsulating carotenoid. The method comprises 1) a step of completely dissolving a protecting colloid, sucrose or glucose, ascorbyl palmitate and EDTA into water, and adjusting pH to 10-11 to obtain a water phase A; 2) a step of completely dissolving carotenoid and an antioxidant into a solvent to obtain an oil phase B; 3) a step of adding the oil phase B into the water phase A under a condition of high-speed shearing and high-speed stirring; emulsifying the mixture to form an initial emulsion by stirring at a high speed; and heating and removing the solvent to obtain a microemulsion; and 4) a step of adding the obtained microemulsion into a spray drying system; and obtaining carotenoid particles or powder after spray drying. The carotenoid particles or powder prepared by the method have advantages of good dispersibility, high stability, good light permeability and small particle sizes.

Description

technical field [0001] The invention relates to a preparation method of carotenoid granules or powder, in particular to a stable microencapsulation method of carotenoid. Background technique [0002] At present, the important role of carotenoids, such as β-carotene, canthaxanthin, astaxanthin, etc. as feed colorants, food colorants or food additives has been recognized by people. In recent years, there have been many reports on the functional role of carotenoids. However, carotenoids are insoluble in water, have a high melting point, and are sensitive to light, heat, and oxygen. These properties of carotenoids are particularly unfavorable for the coloring of aqueous media, since due to their water insolubility it is extremely difficult to achieve a uniform or sufficiently intense coloring effect. In the case of canthaxanthin (canthaxanthin), these properties, in particular water insolubility, lead to very limited bioavailability in pharmaceutical dosage forms containing sa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23P1/04A23L1/27A23L5/40A23P10/30
Inventor 刘庆辉杨伟涛朱萍
Owner 肇庆巨元生化有限公司
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