Chitosan microspheres prepared from chitosan solution with pH value of 6-8 and preparation method of chitosan microspheres

Abstract

The invention discloses a microsphere material prepared from a chitosan solution with the pH value of 6-8 and a preparation method of the microsphere material. The preparation method comprises the following steps: (1) preparing a dispersion liquid; (2) adding chitosan into the dispersion liquid, controlling the temperature to range from a freezing point to 35 DEG C, introducing carbon dioxide intothe solution, stirring to dissolve the chitosan, stopping introduction of the carbon dioxide after the chitosan is completely dissolved, and defoaming to obtain a transparent chitosan solution with the pH value of 6-8; and (3) enabling the chitosan aqueous solution and an oil phase to form chitosan emulsion drops through a membrane emulsifier or microfluidic equipment or a conventional stirring device, and curing the emulsion drops through a coagulator or a chemical cross-linking agent to form the chitosan microspheres. The microsphere material and the method have the beneficial effects that:the method for preparing the chitosan microspheres is carried out in an environment with the pH value of 6-8, and degradation of a chitosan molecular chain can be effectively weakened; and the process of preparing the chitosan microspheres is environment-friendly, so that the production efficiency is improved, and the production cost is reduced.

Description

technical field [0001] The invention belongs to the field of natural polymers, and in particular relates to a chitosan microsphere prepared by using a chitosan solution with a pH value of 6-8 and a preparation method thereof. Background technique [0002] Chitosan is the product of deacetylation of chitin. When the degree of deacetylation of chitin is above 55%, chitin turns into chitosan which can be dissolved in acidic aqueous solution. Chitosan has good biocompatibility and biodegradability, can promote wound healing, and has hemostatic effect. Dissolving chitosan to obtain chitosan solution can prepare new materials such as chitosan fiber, chitosan film, chitosan hydrogel, chitosan airgel, chitosan microspheres, etc. It has good application prospects in medical materials, flexible electronic devices, heat insulation materials and other fields. [0003] There are a large number of hydrogen bonds in and between molecules of chitosan, so it is difficult to dissolve in wat...

AI Technical Summary

Problems solved by technology

[0005] Chitosan is dissolved under acidic or alkaline conditions, and the solution may have the problem of further degradation of chitosan in the engineering of treatment or processing

In addition, during the process of preparing and processing microspheres, there will still be acidic and alkaline substances remaining in them, which will lead to possible degradation of chitosan microspheres during use and affect their performance.