Chitosan microspheres prepared from chitosan solution with pH value of 6-8 and preparation method of chitosan microspheres

A technology of chitosan solution and chitosan microspheres is applied in the field of natural polymers, which can solve the problems of chitosan degradation and affect performance, and achieve the effects of increasing functionality, improving production efficiency and reducing production costs.

Active Publication Date: 2020-10-09
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chitosan is dissolved under acidic or alkaline conditions, and the solution may have the problem of further degradation of chitosan in the engineering of treatment or processing
In addition, during the process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Shrimp shells are soaked in lye to remove protein, soaked in acid solution to remove inorganic salts, and decolorized with hydrogen peroxide solution to obtain purified chitin. Chitin is heated in an aqueous sodium hydroxide solution with a mass molar concentration of 50 wt% for 1 hour to carry out a deacetylation reaction to obtain chitosan with a deacetylation degree of about 70%.

[0035] An aqueous urea solution having a concentration of 6% by weight was used as a dispersion liquid. According to the mass ratio of chitosan and dispersion liquid is 1:7, at 35 ℃, carbon dioxide is passed into the mixture and stirred, when the chitosan is completely dissolved, the carbon dioxide is stopped, and a transparent Chitosan solution, there is some chitosan insoluble matter at the bottom of the centrifuge tube. The chitosan microsphere material was prepared by using the chitosan solution after removing the insoluble matter.

[0036] Chitosan stock solution and oil phase (contai...

Embodiment 2

[0038] Crab shells are soaked in lye to remove protein, soaked in acid solution to remove inorganic salts, and decolorized with hydrogen peroxide solution to obtain purified chitin. Chitin is heated in an aqueous potassium hydroxide solution with a mass molar concentration of 55 wt% for 2 hours to carry out a deacetylation reaction to obtain chitosan with a deacetylation degree of about 60%.

[0039] An aqueous urea solution having a concentration of 18 wt% was used as a dispersion liquid. Mix according to the mass ratio of chitosan and dispersion liquid as 1:1000, at 20 ℃, pass carbon dioxide into the mixture and stir, stop feeding carbon dioxide when chitosan is completely dissolved, and get transparent after centrifugal defoaming Chitosan solution, there is a very small part of chitosan insoluble matter at the bottom of the centrifuge tube. The chitosan microsphere material was prepared by using the chitosan solution after removing the insoluble matter.

[0040] The hydro...

Embodiment 3

[0042] The squid bones are soaked in lye to remove protein, and soaked in acid to remove inorganic salts to obtain purified chitin. Chitin is heated in an aqueous potassium hydroxide solution with a mass molar concentration of 56 wt% for 2 hours to carry out a deacetylation reaction to obtain chitosan with a deacetylation degree of about 60%.

[0043] An aqueous urea solution having a concentration of 60 wt% was used as a dispersion liquid. Mix according to the mass ratio of chitosan and dispersion liquid at 1:100, at 0 ℃, pass carbon dioxide into the mixture and stir, stop feeding carbon dioxide when chitosan is completely dissolved, and obtain a transparent shell after centrifugal defoaming Polycan solution, there is no chitosan insoluble matter at the bottom of the centrifuge tube. Chitosan solution was used to prepare chitosan microsphere material.

[0044] The hydrophobic membrane with a pore size of 13 microns is soaked in petroleum ether to fully wet the porous membra...

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Abstract

The invention discloses a microsphere material prepared from a chitosan solution with the pH value of 6-8 and a preparation method of the microsphere material. The preparation method comprises the following steps: (1) preparing a dispersion liquid; (2) adding chitosan into the dispersion liquid, controlling the temperature to range from a freezing point to 35 DEG C, introducing carbon dioxide intothe solution, stirring to dissolve the chitosan, stopping introduction of the carbon dioxide after the chitosan is completely dissolved, and defoaming to obtain a transparent chitosan solution with the pH value of 6-8; and (3) enabling the chitosan aqueous solution and an oil phase to form chitosan emulsion drops through a membrane emulsifier or microfluidic equipment or a conventional stirring device, and curing the emulsion drops through a coagulator or a chemical cross-linking agent to form the chitosan microspheres. The microsphere material and the method have the beneficial effects that:the method for preparing the chitosan microspheres is carried out in an environment with the pH value of 6-8, and degradation of a chitosan molecular chain can be effectively weakened; and the process of preparing the chitosan microspheres is environment-friendly, so that the production efficiency is improved, and the production cost is reduced.

Description

technical field [0001] The invention belongs to the field of natural polymers, and in particular relates to a chitosan microsphere prepared by using a chitosan solution with a pH value of 6-8 and a preparation method thereof. Background technique [0002] Chitosan is the product of deacetylation of chitin. When the degree of deacetylation of chitin is above 55%, chitin turns into chitosan which can be dissolved in acidic aqueous solution. Chitosan has good biocompatibility and biodegradability, can promote wound healing, and has hemostatic effect. Dissolving chitosan to obtain chitosan solution can prepare new materials such as chitosan fiber, chitosan film, chitosan hydrogel, chitosan airgel, chitosan microspheres, etc. It has good application prospects in medical materials, flexible electronic devices, heat insulation materials and other fields. [0003] There are a large number of hydrogen bonds in and between molecules of chitosan, so it is difficult to dissolve in wat...

Claims

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Application Information

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IPC IPC(8): C08J3/16C08J3/05C08J3/24B01J13/14C08B37/08C08L5/08C08K3/04C08K7/00C01B32/05
CPCB01J13/14C08B37/0003C08B37/003C08J3/05C08J3/16C08J3/24C08J2305/08C08J2405/08C08K7/00C08K2201/011C08K3/042C01B32/05
Inventor 蔡杰钟奕张俐娜
Owner WUHAN UNIV
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