Method of regulating microsphere drug-load rate by treating calcium alginate microspheres with sodium chloride solution

A technology of sodium chloride solution and calcium alginate is applied in pharmaceutical formulations, medical preparations of non-active ingredients, and bulk delivery, etc., which can solve the problem that the drug loading of microspheres is not easy to control, and the drug loading and embedding rate are inconsistent. It can achieve the effect of good application prospect, high encapsulation rate and wide source of raw materials.
CN102631680AInactive Publication Date: 2012-08-15ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2012-08-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method of regulating microsphere drug-load rate by treating calcium alginate microspheres with sodium chloride solution. The method comprises the following steps: preparing calcium alginate microspheres with uniform grain diameter by adopting a membrane emulsification-gelatinization method; soaking the microspheres with sodium chloride solutions with different concentrations to substitute sodium ions for part of calcium ions in the calcium alginate microspheres, and then cleaning with ultrapure water; and soaking the treated microspheres into medicinal solution with positive charges, and loading drugs by virtue of static effect to obtain the calcium alginate microspheres with different drug-load rates finally. The preparation method is easy and controllable, the material sources are wide, the drug-load rate of microspheres can be conveniently adjusted, and the method has the advantage of excellent application prospect.
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Description

technical field

[0001] The invention relates to a method for preparing microspheres and regulating their drug loading. Especially the method of treating the microspheres with different concentrations of sodium chloride solutions to regulate the drug loading of the microspheres. Background technique

[0002] Polymer microspheres refer to a class of polymer materials with micron-scale diameters and spherical shapes. In recent years, polymer microspheres have been widely studied due to their potential huge application value in the fields of medicine, biochemistry, and electronic information. At present, the main preparation methods of microspheres are spray drying method, extrusion method, interfacial and in-situ polymerization method, phase separation method and multiple phase emulsion method. These methods have large yields, but the particle size distribution of the prepared microspheres is mostly very wide, which limits the application in some fields. Membrane emulsificat...

Claims

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