Monodisperse copolymer microsphere and preparation method thereof

A monodisperse and copolymerization technology, applied in the field of polymer chemistry, can solve the problems of adsorption sample range and adsorption effect limitation, and achieve the effect of narrow particle size distribution of microspheres, good emulsion monodispersity, and high sample capacity.

Active Publication Date: 2015-11-11
天津博纳艾杰尔科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Both have the characteristics of simple steps, easy manipulation, and uniform and controllable particle size of the product, but neither of them has designed the reactant an...

Method used

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  • Monodisperse copolymer microsphere and preparation method thereof
  • Monodisperse copolymer microsphere and preparation method thereof
  • Monodisperse copolymer microsphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Mix 1.0 g of sodium lauryl sulfate, 0.5 g of polyvinylpyrrolidone, and 1000 mL of deionized water, and stir at 30° C. for 3 hours to form an aqueous phase. Mix 50g of N-vinylpyrrolidone, 70g of divinylbenzene, 1.0g of azobisisobutyronitrile, 60g of toluene, and 60g of liquid paraffin to form an oil phase. Select a 5μm SPG membrane to prepare a monodisperse emulsion. Under a nitrogen pressure of 0.06MPa, press the oil phase through the membrane into the water phase to form an emulsion. For the emulsion, see figure 1 .

[0057] The emulsion was transferred into a four-neck flask, nitrogen gas was passed for 30 minutes, the stirring speed was 150 rpm, and the reaction was carried out at 80° C. for 15 hours.

[0058] Finally, the steps of filtering, washing, re-filtering, drying, and porogen extraction are carried out according to conventional methods, and the copolymerized microspheres are recovered. The obtained copolymerized microspheres have good monodispersity, a par...

Embodiment 2

[0060] 1.0 g of dioctyl sodium succinate sulfonate, 0.5 g of polyvinylpyrrolidone and 1000 mL of deionized water were mixed, and stirred at 30° C. for 3 hours to form an aqueous phase. Mix 40g of N-vinylpyrrolidone, 10g of methyl methacrylate, 70g of divinylbenzene, 1.0g of azobisisobutyronitrile, and 60g of toluene to form an oil phase. A 1.8 μm SPG membrane was selected to prepare a monodisperse emulsion. Under a nitrogen pressure of 0.08 MPa, the oil phase was pressed through the membrane into the water phase to form an emulsion.

[0061] The emulsion was transferred into a four-necked flask, nitrogen gas was passed for 30 minutes, the stirring speed was 180 rpm, and the reaction was carried out at 80° C. for 15 hours.

[0062] Finally, the steps of filtering, washing, re-filtering, drying, and porogen extraction are carried out according to conventional methods, and the copolymerized microspheres are recovered. The obtained copolymerized microspheres have good monodispers...

Embodiment 3

[0064] Mix 1.0 g of sodium lauryl sulfate, 0.6 g of polyvinylpyrrolidone, and 1000 mL of deionized water, and stir at 30° C. for 3 hours to form an aqueous phase. Mix 60g of N-vinylpyrrolidone, 50g of divinylbenzene, 1.0g of azobisisobutyronitrile, and 100g of toluene to form an oil phase. A 10 μm SPG membrane was selected to prepare a monodisperse emulsion, and under a nitrogen pressure of 0.05 MPa, the oil phase was pressed through the membrane into the water phase to form an emulsion.

[0065] The emulsion was transferred into a four-necked flask, nitrogen gas was passed for 30 minutes, the stirring speed was 180 rpm, and the reaction was carried out at 80° C. for 15 hours.

[0066] Finally, the steps of filtering, washing, re-filtering, drying, and porogen extraction are carried out according to conventional methods, and the copolymerized microspheres are recovered. The obtained copolymerized microspheres have good monodispersity, a particle size of 78 μm, and a specific ...

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Abstract

The invention provides a preparation method of a monodisperse copolymer microsphere with uniform particle size and controllable dimension. The method comprises the steps that a membrane emulsification method is used, oil phase and water phase are prepared into stable emulsion, a liquid drop is taken as a nucleus to conduct a polymerization reaction, and the monodisperse copolymer microsphere is prepared; the particle size of the finally obtained microsphere can be controlled by adjusting the pore diameter of a membrane and applied pressure, so that the form and the performance of the product are easy to control, meanwhile, uniformity of particle size distribution and the yield of the product are increased, the operation is easy, and the energy consumption is low. The invention provides the monodisperse copolymer microsphere, the particle size is uniform, the dimension is controllable, the adsorption capacity and the sample capacity are high, pH range of suitable samples is wide, and the monodisperse copolymer microsphere which serves as solid phase extraction packing has the wide application prospect in the aspects of extraction, enrichment and purification of compounds.

Description

technical field [0001] The invention relates to the field of polymer chemistry, in particular to the preparation of monodisperse copolymerized microspheres by a membrane emulsification method. Background technique [0002] Solid phase extraction (SPE) is a technology developed in recent years, and has been widely used in the fields of medicine, food, environment, and fine chemical industry. In solid phase extraction, solid phase extraction column packing plays a very critical role. Monodisperse polymer microspheres have the characteristics of large specific surface area, strong adsorption, good mechanical properties, wide range of solvent resistance, and convenient recycling and reuse. As a solid adsorbent for solid phase extraction, it can effectively increase the number of theoretical plates, chromatographic Separation efficiency and detection accuracy, improved fluidity. Such filled particles with different functional groups introduced on the surface or inside can reali...

Claims

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Application Information

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IPC IPC(8): C08F212/36C08F226/10C08F220/14C08F2/26C08J9/28B01J20/285B01J20/30
Inventor 周丽李海涛
Owner 天津博纳艾杰尔科技有限公司
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