Pickering emulsion with uniform particle size, and preparation method and application thereof

An emulsion and uniform technology, applied in the field of materials, can solve the problems of wide particle size distribution, unstable emulsion, uncontrollable emulsion particle size, etc., to achieve uniform particle size, avoid aging phenomenon, and facilitate long-term storage.

Active Publication Date: 2014-08-27
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The emulsion particle size distribution range prepared by the stirring method used in this document is wide

Method used

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  • Pickering emulsion with uniform particle size, and preparation method and application thereof
  • Pickering emulsion with uniform particle size, and preparation method and application thereof
  • Pickering emulsion with uniform particle size, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Accurately weigh 0.5g of polylactic acid-glycolic acid copolymer (LA / GA75 / 25) particles, the molecular weight is 5kDa, the particle size is 10nm, 100nm, 500nm, 1μm, 10μm, 20μm, add 50mL of water phase to make it evenly dispersed , to obtain an aqueous suspension with a particle concentration of 1% (w / v). The pH of the aqueous phase is 8. Add 12.5 mL of hexadecane to the membrane emulsification device, and the oil-water ratio is 1:4. The device is equipped with an SPG membrane (distribution coefficient 15%) with a membrane pore size of 200 μm, which is submerged in the water phase. The nitrogen pressure is 0.1 kPa, the oil phase is pressed out through the SPG membrane, and directly enters the water phase, and a uniform emulsion is formed at a stirring rate of 50 rpm. Due to the biodegradability of polylactic acid-glycolic acid, the stability of the emulsion was studied by the emulsion centrifugation method, that is, the emulsion was centrifuged for 10 minutes under the...

Embodiment 2

[0110] Accurately weigh 0.5g polylactic acid-glycolic acid copolymer (LA / GA75 / 25) particles, its molecular weight is 5kDa, particle diameter is 100nm, add 50mL water phase, make it disperse evenly, obtain particle concentration to be 1% (w / v) an aqueous suspension. The pH of the aqueous phase is 8. Add 12.5 mL of hexadecane to the membrane emulsification device, and the oil-water ratio is 1:4. The device was equipped with a polytetrafluoroethylene membrane (distribution coefficient 20%) with a pore size of 200 μm, which was submerged in the water phase. The nitrogen pressure is 0.1kPa, the oil phase is pressed out through the polytetrafluoroethylene membrane, and directly enters the water phase, and a uniform emulsion is formed at a stirring rate of 50rpm. The emulsion type is O / W type, and the average particle size is 500μm. The CV is 13.1%. The emulsion particle size distribution is as figure 2 shown.

[0111] Due to the biodegradability of poly(lactic-co-glycolic aci...

Embodiment 3

[0113] Accurately weigh 0.5g polylactic acid-glycolic acid copolymer (LA / GA50 / 50) particles, its molecular weight is 200kDa, particle diameter is 100nm, add 50mL aqueous phase, make it disperse evenly, obtain particle concentration to be 1% (w / v) an aqueous suspension. The pH of the aqueous phase is 8. Add 12.5 mL of hexadecane to the membrane emulsification device, and the oil-water ratio is 1:4. The device is equipped with an SPG membrane (distribution coefficient 15%) with a membrane pore size of 200 μm, which is submerged in the water phase. The nitrogen pressure is 0.1kPa, the oil phase is pressed out through the SPG membrane, and directly enters the water phase, and a uniform emulsion is formed at a stirring rate of 50rpm. The emulsion type is O / W type, the average particle size is 500μm, and the CV is 13.4 %.

[0114] Due to the biodegradability of polylactic acid-glycolic acid, the emulsion stability was studied by emulsion centrifugation. After centrifugation und...

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Abstract

The invention discloses a Pickering emulsion with uniform particle size and a preparation method and application thereof. The uniform and stable Pickering emulsion is formed by using a solid particle as a stabilizing agent, dispersing the solid particle in a water (or oil) phase, then subjecting the dispersed solid particle and an oil (or water) phase to emulsification and then allowing a formed pre-emulsion to pass through a membrane emulsification apparatus. Or the uniform and stable Pickering emulsion is formed by allowing a dispersed phase (water phase or oil phase) to pass through membrane holes under pressing and then to enter a continuous phase (oil phase or water phase) with the dispersed solid particle and then enabling an emulsion to fall off from the membrane holes under the action of external force. The preparation method is simple; through adjusting of the proportion of water and oil phases, particle concentration, the size of the particle and a microporous membrane, the properties of the emulsion are regulated and controlled, the prepared emulsion is stable and has a uniform and controllable particle size and enhanced stability, usage of a traditional emulsifier is avoided, and toxicity to human bodies and environmental pollution can be reduced; and the emulsion can be extensively used in fields like biological medicine, cosmetics, food, petroleum and waste water treatment.

Description

technical field [0001] The invention relates to a Pickering emulsion and a preparation method and application thereof, in particular to a Pickering emulsion with uniform particle size and a preparation method thereof, belonging to the field of materials. Background technique [0002] Pickering emulsion is a new type of emulsion system in which solid particles replace traditional surfactants. Such as figure 1 As shown, the stabilization mechanism of the emulsion is mainly through the adsorption of solid particles on the oil-water interface to form a single-layer or multi-layer structure of solid particles, thereby stabilizing the emulsion. [0003] Compared with emulsions stabilized by traditional surfactants, it has outstanding advantages: (1) less toxic and side effects on the human body; (2) reducing environmental pollution; (3) strong emulsion stability. Therefore, Pickering emulsion has very important research and application value in the fields of food, cosmetics and ...

Claims

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Application Information

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IPC IPC(8): B01F3/08B01F17/00C09K23/00
Inventor 马光辉齐峰吴颉周炜清
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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