Solid-state avermectin particle preparation and preparation method and application thereof

An abamectin and solid state technology, applied in the field of solid abamectin particulate preparation and preparation thereof, can solve the problems of occurrence of phytotoxicity, poor control effect, and high energy consumption of the preparation process of the grinding method, and achieves the solution of unstable problems. Effect

Active Publication Date: 2016-08-17
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of the grinding method requires high energy consumption, and the low grinding precision is not conducive to the adjustment and control of the particle size of the pesticide suspended particles
In addition, the storage stability of the suspension is poor, and the product is p...

Method used

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  • Solid-state avermectin particle preparation and preparation method and application thereof
  • Solid-state avermectin particle preparation and preparation method and application thereof
  • Solid-state avermectin particle preparation and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Embodiment 1, preparation solid-state Abamectin microsphere

[0081] (1) The drug avermectin was dissolved in dichloromethane, and configured into a 50 mg / mL solution as the oil phase.

[0082] (2) Dissolving polyvinyl alcohol with a number average molecular weight of 30,000 to 70,000 in water to prepare a 1.0% polyvinyl alcohol aqueous solution as the external water phase.

[0083] (3) After the oil phase obtained in step (1) is mixed with the external water phase obtained in step (2) according to the volume ratio of 1:20, mechanically stir at a stirring speed of 400 rpm for 1 min to obtain oil-in-water primary emulsion.

[0084] (4) Pour the primary emulsion system obtained in step (3) into the storage tank of the rapid membrane emulsification device, and pass through the membrane (9.0 microns in pore size) 3 times under 80 kPa nitrogen pressure to obtain a homogeneous oil-in-water emulsion.

[0085] (5) Stir the oil-in-water emulsion obtained in step (4) at room te...

Embodiment 2

[0087] Embodiment 2, preparation solid-state Abamectin microsphere

[0088] (1) The drug avermectin was dissolved in dichloromethane, and configured into a 30 mg / mL solution as the oil phase.

[0089] (2) Dissolving polyvinyl alcohol with a number average molecular weight of 30,000 to 70,000 in water to prepare a 2.0% polyvinyl alcohol aqueous solution as the external water phase.

[0090] (3) After the oil phase obtained in step (1) is mixed with the external water phase obtained in step (2) according to the volume ratio of 1:35, mechanically stir at a stirring speed of 50 rpm for 6 minutes to obtain oil-in-water primary emulsion.

[0091] (4) Pour the mixed emulsion system obtained in step (3) into the storage tank of the rapid membrane emulsification device, and pass through the membrane (7.0 microns in aperture) 5 times under 100 kPa nitrogen pressure to obtain an oil-in-water emulsion with uniform particle size.

[0092] (5) Stir the oil-in-water emulsion obtained in st...

Embodiment 3

[0094] Embodiment 3, preparation solid-state Abamectin microsphere

[0095] (1) The drug avermectin was dissolved in dichloromethane to form a 20 mg / mL solution as the oil phase.

[0096] (2) Dissolving polyvinyl alcohol with a number average molecular weight of 30,000 to 70,000 in water to prepare a 1.0% polyvinyl alcohol aqueous solution as the external water phase.

[0097] (3) After the oil phase obtained in step (1) is mixed with the external water phase obtained in step (2) according to the volume ratio of 1:10, mechanically stir for 2 minutes at a stirring speed of 200 rpm to obtain oil-in-water primary emulsion.

[0098] (4) Pour the mixed emulsion system obtained in step (3) into the storage tank of the rapid membrane emulsification device, and pass through the membrane (2.5 microns in aperture) 5 times under a nitrogen pressure of 150 kPa to obtain an oil-in-water emulsion with uniform particle size.

[0099] (5) The oil-in-water emulsion obtained in step (4) was s...

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Abstract

The invention discloses a solid-state avermectin particle preparation and a preparation method and application thereof. Particles comprise microspheres and microcapsules. A preparation method of the microspheres includes following steps: 1), dissolving avermectin in an organic solvent to obtain an organic solution of avermectin as an oil phase; 2), dissolving a stabilizer in water to obtain a stabilizer water solution as an outer water phase; 3), mixing the oil phase with the outer water phase for mechanical stirring to obtain an oil-in-water primary emulsion; 4), utilizing a membrane emulsification device to perform membrane filtering on the oil-in-water primary emulsion under action of nitrogen to obtain an oil-in-water emulsion; 5), sequentially stirring and centrifuging the oil-in-water emulsion to collect precipitate, washing with water, and drying to obtain the solid-state avermectin microspheres. A membrane emulsification method is combined with an emulsion solvent evaporation method to obtain the solid-state avermectin microspheres and microcapsule preparation which has the advantages of stability in storage, safety and convenience in transport and use and low cost.

Description

technical field [0001] The invention belongs to the field of pesticides, and relates to a solid abamectin microparticle preparation and a preparation method and application thereof. Background technique [0002] Pesticides are the material basis for preventing major biological disasters and promoting the sustainable and stable growth of agricultural production. At present, the pesticide preparations used in my country's agricultural production are mainly emulsifiable concentrates and wettable powders. EC is a homogeneous liquid prepared by dissolving the original drug in organic solvents such as toluene and xylene in proportion, and adding appropriate amount of additives. Although this type of preparation is diluted with water and it is easier to spray, a large amount of organic solvents in the product will all enter the environment, which will easily lead to environmental pollution, seriously endanger human health, and also greatly increase the cost of pesticide preparatio...

Claims

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Application Information

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IPC IPC(8): A01N43/90A01N25/28A01N25/08A01P7/04
CPCA01N25/08A01N25/28A01N43/90
Inventor 吴德成刘宝霞
Owner INST OF CHEM CHINESE ACAD OF SCI
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