Method for preparing starch micro-capsules and microballons on basis of fast membrane emulsification method

Abstract

The invention discloses a method for preparing starch micro-capsules and microballons on the basis of a fast membrane emulsification method. The fast membrane emulsification method is combined with an oil/water and water/oil/water solution volatilization technology, the size of the prepared starch micro-capsules and microballons can be adjusted and controlled between 0.3 micrometer and 7 micrometers by adjusting the membrane emulsification process parameters, and the particle size distribution is uniform. The prepared starch micro-capsules and microballons can be used as drug carriers to contain water-soluble or oil-soluble drugs, can be embedded with inorganic particles such as magnetic particles, hydroxyapatite and tricalcium phosphate, can be used for adsorbing heavy metal ions such as Cu2+, Pd2+, Cd2+ and Hg2+, and can also be loaded with the enzymic catalytic reaction, and the application prospect is wide.

Description

technical field [0001] The invention belongs to the field of preparation of microcapsules and microspheres, and in particular relates to a method for preparing starch microcapsules and microspheres based on a rapid membrane emulsification method. Background technique [0002] Starch is a renewable, easily degradable, environmentally friendly natural polymer material with good biocompatibility. Because of its widespread existence in nature and low price, besides food processing, starch has been more and more used in chemical engineering, biomedicine and other fields. However, native starch has poor stability, is difficult to dissolve, and is difficult to process and shape, which greatly limits its application value. The properties of starch derivatives through physical or chemical modification can be greatly improved, laying the foundation for their wide application. [0003] Usually, physical modification mainly includes adding polar small molecules as plasticizers, improv...

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Problems solved by technology

The physical method uses ethanol or water as the medium, and the starch granules are broken under the action of mechanical force. The particle size of the microspheres prepared by this method is not uniform, the loss is large, and the cost is high; the chemical method is mainly adsorbed or embedded in starch. Contains Fe 2+ and Fe 3+ The magnetic substance can be used to obtain magnetically responsive starch microspheres to achieve the purpose of targeted therapy; the reverse microemulsion method is to dissolve soluble starch in water, and then disperse it in an organic solution to form a uniform and stable microemulsion, and then add an appropriate amount of cross The linking agent cross-links the dissolved starch into fine microspheres and precipitates from the solution. Commonly used cross-linking agents include epichlorohydrin, bisacrylamide, metaphosphate, etc. This method can also prepare hollow starch microspheres, but The formula design is more complicated and the conditions are not easy to grasp

[0006] The microspheres prepared by the above methods generally have inhomogeneous sizes, and the conditions are complex and harsh, so it is difficult to simply control the particle size and distribution of the microspheres; at the same time, there is no simple and controllable method to prepare and adjust the hollow spacers with uniform sizes. Starch microspheres

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