The application provides a preparation method of sanshool, and belongs to the field of
natural product separation and purification, which takes dried
Zanthoxylum bungeanum Maxim peel as
raw material, adopts supercritical CO2 extraction, molecular
distillation and
solvent crystallization combined process, utilizes
solubility difference of two isomers to realize preferential
crystallization of hydroxyl-beta-sanshool, and through secondary recrystallization, HPLC≥98%
monomer can be obtained; then through homogenization-
petroleum ether extraction
impurity removal and
alcohol crystallization, HPLC≥98% hydroxyl-alpha-sanshool can be obtained. The preparation method has low cost, simple operation, batch stability and large-scale production, solves the problems of difficult separation, low purity, small
processing capacity and high cost in the prior art, realizes synchronous and efficient preparation of two pungent monomers, greatly improves the
utilization rate and added value of
Zanthoxylum bungeanum Maxim resources, and supports high-value utilization of
Zanthoxylum bungeanum Maxim industry.