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Preparation method for hydroxyethyl starch

A technology of hydroxyethyl starch and starch, which is applied in the field of medicine, can solve the problems of low decolorization efficiency, limited adsorption capacity, and large adsorption capacity, and achieve the effects of improving comprehensive performance, reducing size, and enhancing permeability

Active Publication Date: 2012-08-01
李育强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The preparation method of the 130 / 0.4 hydroxyethyl starch uses insoluble chitosan as a decolorizing agent, which overcomes the low decolorization efficiency, limited adsorption capacity, long feed liquid filtration time, and feed liquid decolorization brought by the traditional process using activated carbon for decolorization. For defects such as endotoxin exceeding the limit, not only the adsorption speed is 5 times faster than that of activated carbon, but also the adsorption capacity is 5.5 times higher than that of activated carbon, and insoluble chitosan can be regenerated and used many times, which is not easy to cause secondary pollution, and has good mechanical strength It does not affect the filtration, and at the same time ensures that the raw material batches of hydroxyethyl starch produced are stable, reliable in quality, and in line with national standards

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) Pretreatment

[0055] 180kg of amylopectin starch was dried at 130°C for 2h.

[0056] (2) Gelatinization and hydrolysis

[0057] Add 510kg of water for injection into the reaction tank, then add 1.88L of 12mol / L hydrochloric acid solution, slowly add the dried amylopectin under stirring, heat up to 90°C rapidly, keep the temperature for 1 hour and keep stirring for hydrolysis. After 1 hour, take a small amount of samples every 10 minutes, and quickly use a flat viscometer (inner diameter 1.2mm, viscometer constant: 0.3842mm) 2 / S 2 ) to measure the outflow time in the sample, when the reserved time is about 1 minute 10 seconds to 1 minute 15 seconds, stop heating, rapidly cool down to 18-25°C, and at the same time, add 2L 10mol / l sodium hydroxide solution to neutralize Terminate the hydrolysis reaction.

[0058] (3) Hydroxyethyl etherification

[0059] When the hydrolyzed starch solution is cooled to about 25°C, transfer it to the hydroxyethylation reaction ket...

Embodiment 2

[0067] (1) Pretreatment

[0068] 180kg of amylose corn starch was dried under vacuum at 50°C for 8h.

[0069] (2) Gelatinization and hydrolysis

[0070] Add 3420kg of water for injection into the reaction tank, then add 6.7L of 4mol / L phosphoric acid solution, slowly add the dried amylopectin under stirring, heat up to 60°C rapidly, keep the temperature for 1 hour and keep stirring for hydrolysis. After 1 hour, take a small amount of samples every 10 minutes, and quickly use a flat viscometer (inner diameter 1.2mm, viscometer constant: 0.3842mm) 2 / S 2 ) to measure the outflow time in the sample, when the reserved time is about 1 minute 10 seconds to 1 minute 15 seconds, stop heating, rapidly cool to 18-25°C, and at the same time, add 2L 10mol / l potassium hydroxide solution to neutralize Terminate the hydrolysis reaction.

[0071] (3) Hydroxyethyl etherification

[0072]When the hydrolyzed starch solution is cooled to about 25°C, transfer it to the hydroxyethylation react...

Embodiment 3

[0080] (1) Pretreatment

[0081] 180kg of amylose corn starch was dried at 170°C for 0.5h.

[0082] (2) Gelatinization and hydrolysis

[0083] Add 220kg of water for injection into the reaction tank, then add 15L of 6mol / L sulfuric acid solution, slowly add the dried amylopectin under stirring, heat up to 120°C rapidly, keep the temperature for 1h and keep stirring at this temperature for 1h Then take a small amount of samples every 10 minutes, and quickly use a flat viscometer (inner diameter 1.2mm, viscometer constant: 0.3842mm 2 / S 2 ) to measure the outflow time in the sample, when the reserved time is about 1 minute 10 seconds to 1 minute 15 seconds, stop heating, rapidly cool to 18-25°C, and at the same time, add 2L 10mol / l potassium hydroxide solution to neutralize Terminate the hydrolysis reaction.

[0084] (3) Hydroxyethyl etherification

[0085] When the hydrolyzed starch solution is cooled to about 25°C, transfer it to the hydroxyethylation reaction kettle, con...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a preparation method for 130 / 0.4 hydroxyethyl starch. The method mainly comprises the following steps of gelatinizing and hydrolyzing, performing hydroxyethyl etherification, performing rough filtration, decolorizing and clarifying, performing refined filtration, performing ultrafiltration and drying. According to the method, insoluble chitosan is used for decolorization and clarification, and the conventional process in which activated carbon is used for decolorization is improved, so production efficiency and the quality of hydroxyethyl starch are improved. The method overcomes the defects that decolorization efficiency is low, the adsorption amount is limited, filtration time of feed liquid is long, and toxin in the feed liquid exceeds the limit and the like because the active carbon is used for decolorization in the conventional process, adsorption speed of insoluble chitosan is 6 times that of the active carbon, and the adsorption amount of insoluble chitosan is 5.5 times more than that of the active carbon; the insoluble chitosan can be repeatedly used, secondary pollution is avoided, high mechanical intensity is achieved, and filtration is not influenced; and the raw materials of the produced hydroxyethyl starch are stable in batch, and the quality of the produced hydroxyethyl starch is reliable and meets the national standard.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular, the invention relates to a preparation method of hydroxyethyl starch, more specifically, the invention relates to a preparation method of 130 / 0.4 hydroxyethyl starch. Background technique [0002] Starch has become a rich renewable industrial raw material because of its cheap and easy availability. However, native starch has limited its application range due to its structural and performance defects. In the past 20 years at home and abroad, the research on starch and its deep processing has been very active, and great progress has been made in the field of science and technology, and many application fields have been opened up. In foreign countries, modified starch is a high-tech fine chemical product, and its output has accounted for 20% to 30% of the total starch production, and there are more than 2,000 varieties of modified starch. [0003] Hydroxyethyl starch is a modified s...

Claims

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Application Information

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IPC IPC(8): C08B31/12C08B30/04
Inventor 李育强但丽霞顾春艳聂守臻
Owner 李育强
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