Method of granulation by spraying melted nicotinamide

A technology of spray granulation and nicotinamide, which is applied in liquid droplet granulation, organic chemistry, etc., can solve problems such as physical injury of workers, easy moisture absorption of nicotinamide, and dust pollution in workshops, and achieves reduction of screening load, particle size reduction, etc. Good diameter distribution and the effect of reducing energy consumption

Inactive Publication Date: 2009-11-04
HANGZHOU SHENGDA PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the small particle size of the product, dust is flying in the packaging and use places, and the dust pollution in the workshop is serious. On the one hand, it causes product loss, and more seriously, it causes physical injury to workers.
In the process of storage, transportation and use, due to the

Method used

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  • Method of granulation by spraying melted nicotinamide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] refer to figure 1 , a method for melt spray granulation of nicotinamide, the method steps comprising:

[0016] The nicotinamide powder is melted in the melting tank (1), the temperature is 140-160°C, and the pressure is normal pressure; the molten nicotinamide is sent to the upper nozzle of the fluidized bed spray granulation tower (3) by the high pressure pump (2) And atomized into droplets, sprayed down into the fluidized bed, the high-temperature droplets in the fluidized bed contact with the low-temperature nicotinamide particles in the fluidized state and the low-temperature air used for fluidization upwards, the droplets adhere to the particles, As the temperature decreases and solidifies, the particle size becomes larger; at the same time, due to the collision and crushing of the fluidized particles, some fine particles will also be entrained and discharged by the upwardly flowing air through the gas outlet pipe at the top of the prilling tower; the discharged ni...

Embodiment 2

[0018] According to the production process steps of Example 1, the production capacity of nicotinamide melt granulation can reach 200 kg / hour, and the product mesh is between 30-80 mesh. The product does not need to be further dried, and can be directly packaged.

[0019] The present invention proposes a nicotinamide melting spray granulation method, which can produce granular nicotinamide with a particle size of 0.2-0.8 mm, which greatly reduces dust pollution and moisture absorption and agglomeration in packaging, storage and transportation, and use occasions. On the one hand, under the premise of not changing the subsequent feed and other production processes, a suitable product particle size distribution ensures good dispersibility of nicotinamide in subsequent downstream products such as feed.

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Abstract

The invention discloses a method of granulation by spraying melted nicotinamide. The method comprises the following steps: injecting the melted nicotinamide into the spray-granulation tower of a fluidized bed for granulation by a pressure-type spraying nozzle; automatically grading the nicotinamide granules with the granularity being 0.4 to 1.0 mm in the granulation tower by controlling the gas velocity of fluidizing air in the inlet pipe at the lower part of the granulation tower; entering silos through the inlet pipe of the granulation tower of the fluidized bed, and then screening the products within the range of the granularity by a screener; and finally obtaining the nicotinamide granules with the granule size being 0.4 to 1.0 mm. On the one hand, the granular nicotinamide produced by the method of the invention can greatly reduce the dust pollution, moisture absorption and agglomeration occurring to places for packaging, storing, transporting and applying, and on the other hand, the granule sizes of the products are properly distributed so as to ensure the good dispersion of nicotinamide in the following downstream products, such as feed and the like, upon the premise that the following processing technique, such as feed and the like, remains unchanged.

Description

technical field [0001] The invention provides a method for melt-spray granulation of nicotinamide, which belongs to the field of fine chemical industry. Background technique [0002] Nicotinamide (Nicotinamide) is vitamin B3, chemical name 3-pyridine carboxamide, molecular formula C 6 h 6 N 2 O, molecular weight 122.11, melting point 129-131°C, white crystalline powder, easily soluble in water or ethanol. Niacinamide is widely used in medicine, food, and feed industries, and is an indispensable nutrient for the growth and development of humans and animals. In addition, nicotinamide can also be used as plant growth regulator, hair growth promoter, hair dyeing promoter, polymer stabilizer, electroplating solution additive and biochemical reagent, etc. [0003] At present, the production methods of industrial nicotinamide at home and abroad mainly use 3-picoline, 2-methyl-5-ethylpyridine or quinoline as raw materials, and generate nicotinic acid or nicotinic acid through di...

Claims

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Application Information

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IPC IPC(8): B01J2/04C07D213/82
Inventor 姜木根陈银飞卢晗锋
Owner HANGZHOU SHENGDA PHARMA
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