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Functional nano-particle compound cross-linking microsphere powder as well as preparation method and application thereof

A nanoparticle and functional technology, which is applied in the field of monodisperse functional nanoparticle composite microsphere powder and its preparation, can solve the problem that the performance of functional particles is easily affected by the polymerization reaction environment, and there is no composite crosslinking of functional nanoparticles. The problems of phase separation of microspheres and microsphere structures can achieve the effects of accurate and reliable detection results, small coefficient of variation and excellent performance.

Inactive Publication Date: 2013-02-06
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method still faces the following problems: the particle size distribution is wide when preparing micron-scale composite microspheres, the performance of functional particles is easily affected by the polymerization reaction environment, and there may be phase separation between the functional particles and the formed microsphere structure
[0014] However, there is no report on the successful preparation of functional nanoparticle composite cross-linked microspheres using membrane emulsification technology.

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  • Functional nano-particle compound cross-linking microsphere powder as well as preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0067] Example 1 Preparation of Composite Crosslinked Microsphere Powder (1)

[0068] Styrene, divinylbenzene, methacrylic acid, benzoyl peroxide and CdSe / CdS quantum dots with an emission wavelength of 528 nm were dissolved in toluene, the concentration of styrene was 1 g / mL, and the concentration of divinylbenzene was 0.75g / mL, methacrylic acid concentration 0.5 g / mL, benzoyl peroxide concentration 0.001 g / mL, quantum dot concentration 1 nM / L, as the dispersed phase. A ceramic porous membrane with a pore size of 0.5 μm is used, and the dispersed phase is squeezed through the membrane by nitrogen at a pressure of 18 KPa, and then enters a water continuous phase containing an emulsifier SDS concentration of 1 wt.%, and the flow rate of the continuous phase is 0.30 m / s , to obtain an oil-in-water emulsion with uniform droplet size. The emulsion was heated to 70 °C and reacted for 12 h under the protection of nitrogen. After that, the obtained composite microsphere suspensio...

Embodiment 2

[0069] Example 2 Preparation of Composite Crosslinked Microsphere Powder (2)

[0070] Methyl acrylate, divinylbenzene, azobisisobutyronitrile and Fe 3 o 4 The magnetic nanoparticles were dissolved in chloroform with methyl acrylate concentration of 1 g / mL, divinylbenzene concentration of 0.5 g / mL, azobisisobutyronitrile concentration of 0.01 g / mL, Fe 3 o 4 The concentration of magnetic nanoparticles is 0.5 nM / L, which is used as the dispersed phase. The SPG porous membrane with a pore size of 5 μm is used, and the dispersed phase is squeezed through the membrane by nitrogen at a pressure of 21 KPa, and enters the water continuous phase containing the emulsifier SDS concentration of 0.5 wt.%, and the flow rate of the continuous phase is 0.40 m / s , to obtain an oil-in-water emulsion with uniform droplet size. The emulsion was heated to 70 °C and reacted for 12 h under the protection of nitrogen. Afterwards, the obtained microsphere suspension was centrifugally washed 3 ti...

Embodiment 3

[0071] Example 3 Preparation of Composite Crosslinked Microsphere Powder (3)

[0072] Styrene, divinylbenzene, methacrylic acid and NaYF 4 Rare earth nanoparticles were dissolved in xylene at a concentration of 1 g / mL for styrene, 0.5 g / mL for divinylbenzene, and 0.5 g / mL for methacrylic acid. NaYF 4 The concentration of rare earth nanoparticles was 1 nM / L, which was used as the dispersed phase. A SPG porous membrane with a pore size of 3 μm was used, and the dispersed phase was squeezed through the membrane by nitrogen at a pressure of 25 KPa, and then entered into a solution containing 0.001 g / mL initiator potassium persulfate, 0.5 wt.% emulsifier SDS and 0.5 wt.% Water continuous phase of stabilizer PVA, the flow velocity of the continuous phase is 0.35 m / s, and an oil-in-water emulsion with uniform droplet size is obtained. The emulsion was heated to 65 °C and reacted for 12 h under the protection of nitrogen. Afterwards, the obtained microsphere suspension was centr...

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Abstract

The invention relates to functional nano-particle compound cross-linking microsphere powder as well as a preparation method and application of the functional nano-particle compound cross-linking microsphere powder. The functional nano-particle compound cross-linking microsphere powder contains functional nano-particle compound cross-linking microspheres, wherein each functional nano-particle compound cross-linking microsphere comprises a functional nano-particle, a monomer, a crosslinking agent and an initiator, the average particle size of the functional nano-particle compound cross-linking microspheres is 0.1-20 microns, and the particle size distribution variable coefficient is no larger than 9.6 percent. The preparation method is combination of a membrane emulsification technology and an emulsion polymerization method. The invention also relates to a biological detection probe based on the compound cross-linking microsphere powder and application of the probe. The functional nano-particle compound cross-linking microsphere powder as well as the preparation method and the application of the functional nano-particle compound cross-linking microsphere powder have the advantages that the functional nano-particle compound cross-linking microspheres with uniform particle size can be prepared, is in a micron order, has small particle size variable coefficient, is good in monodispersity and performances and has wide application prospect in the field of biological detection, biological medicine and the like.

Description

technical field [0001] The invention relates to the field of preparation and application of micro-nano materials, specifically, monodisperse functional nano-particle composite microsphere powder and its preparation method and application. Background technique [0002] Functional nanoparticle composite microsphere refers to a functional composite microsphere obtained by combining functional nanoparticles and microspheres by a certain method. At present, nanoparticles prepared by various methods have various special optical, electrical, magnetic and biological characteristics, so these characteristics are often endowed to the microsphere itself after being combined with the microsphere. Microspheres also provide support and effective protection for these nanoparticles. At the same time, the chemical and physical properties of the microspheres themselves, such as light sensitivity, pH responsiveness, temperature sensitivity, adsorption properties, and surface active functional...

Claims

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Application Information

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IPC IPC(8): B01J13/02B01J13/14G01N21/64
Inventor 孙康孙锟窦红静李万万王刚
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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