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Thermosensitive bisphenol A (BPA) imprinted polymeric microsphere and application thereof

An imprinted polymer, temperature-sensitive bisphenol technology, applied in the fields of material science and engineering and environmental science, can solve the problems of difficult to fully display the recognition performance, no good carrier loading, small BPA adsorption capacity, etc., and achieves good solution temperature response. The principle is simple and novel, and the effect of improving the adsorption capacity

Active Publication Date: 2014-11-12
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are also some shortcomings that limit its further application. For example, the use of a single recognition monomer generally has a small adsorption capacity for BPA; without a good carrier, the recognition performance is difficult to fully exert, and the imprinted product is unstable and cannot be used for a long time. Preservation; the recognition and adsorption effect of imprinted polymers on BPA can only be effective in the ideal single-factor solution state, and the effect is poor or even ineffective for mixed solutions of different temperatures and different components

Method used

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  • Thermosensitive bisphenol A (BPA) imprinted polymeric microsphere and application thereof
  • Thermosensitive bisphenol A (BPA) imprinted polymeric microsphere and application thereof
  • Thermosensitive bisphenol A (BPA) imprinted polymeric microsphere and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]a. Synthesis of polystyrene seed microspheres: add 100 mL of absolute ethanol, 20 mL of deionized water and 0.7 g of polyvinylpyrrolidone to a 250 mL three-necked flask, then disperse them uniformly by ultrasonication and constant stirring, and then slowly add 5 mL The styrene was purged with nitrogen for 30 min, then 40 mg of azobisisobutyronitrile was added, the temperature of the mixed solution was raised to 60 °C and maintained, and the polymerization reaction was carried out under nitrogen protection for 24 h. The obtained polystyrene microsphere product was washed 6 times with deionized water and absolute ethanol in turn, and the obtained product was vacuum-dried at 40° C. to constant weight, and collected for later use.

[0032] b. Synthesis of hollow porous polystyrene microspheres: add 0.125 g of sodium dodecyl sulfonate and 50 mL of deionized water to a 100 mL two-necked flask, shake to dissolve completely, and then add 0.2 g of the above-synthesized polystyrene...

Embodiment 2

[0040] Weigh 20 mg of T-MIPs and T-NIPs samples respectively, put them in 6 10 mL ground-mouth stopper test tubes, and add 2 mL of BPA and its 5 structural analogs (β-estradiol) with a concentration of 50 mg / L, respectively. , estriol, estrone, cholesterol and phenol) in acetonitrile solution, shake at room temperature for 24h. The mixture was then centrifuged and filtered with a 0.45 μm microporous membrane. The concentration of BPA and its structural analogs in the filtrate was determined by HPLC-UV, and the imprinted products were calculated according to the concentration of various phenolic estrogens. The adsorption capacity was measured 3 times in parallel for each experiment. As a control, 20 mg of T-NIPs were weighed and the same experiment was performed. The result is as Figure 4 As shown, the adsorption capacity of T-MIPs for BPA was significantly higher than that of the other five phenols, indicating the existence of specific sites in T-MIPs with high selectivity ...

Embodiment 3

[0042] Weigh 10 mg of T-MIPs and T-NIPs samples respectively and add them to 2.0 mL of solutions containing different concentrations of BPA (1, 10, 30, 50, 100 mg / L), put them in a 5 mL stoppered glass test tube, and then transfer them immediately After being fully adsorbed for 24 hours in a constant temperature water bath at 20, 33 and 50 °C, the samples were quickly filtered and centrifuged, and filtered with a 0.45 μm microporous membrane. The BPA concentration in the filtrate was quantified by HPLC-UV, and the three temperatures were evaluated. Changes in the BPA adsorption capacity of the lower imprinted polymers. Each group of experiments was measured 3 times in parallel. The result is as Figure 5 As shown, the adsorption of T-MIPs and T-NIPs to different concentrations of BPA has a certain responsiveness with the change of temperature; at the lower critical temperature (LCST) of 33 °C, T-MIPs has the best adsorption effect on template molecules , indicating that the ...

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Abstract

The invention belongs to the field of material sciences and engineering and environmental sciences and particularly relates to a thermosensitive bisphenol A (BPA) imprinted polymeric microsphere and application of the thermosensitive BPA imprinted polymeric microsphere. According to the thermosensitive BPA imprinted polymeric microsphere, polystyrene is used as a carrier, BPA is used as template molecules in combination with thermosensitive material monomers, and the temperature-responsive BPA imprinted polymeric microsphere is obtained through polymerization. The thermosensitive BPA imprinted polymeric microsphere is used for detection of the BPA. The thermosensitive BPA imprinted polymeric microsphere is clear in principle, novel in design, low in cost and easy and convenient to operate; the imprinted polymeric microsphere obtained through dispersion polymerization, swelling polymerization, precipitation polymerization and other methods is regular in morphology, stable in nature, capable of adsorbing the BPA quickly, high in bonding capacity, good in specificity and reproductibility, capable of achieving the standard recovery rate of more than 90% when applied to detection of sea water or yoghourt samples containing the BPA, and good in reuse performance; besides, the obtained intelligent imprinted polymers are sensitive in response to external temperatures, and different temperatures of solutions have a great influence on the adsorption capacity of the thermosensitive BPA imprinted polymeric microsphere.

Description

technical field [0001] The invention belongs to the fields of material science, engineering and environmental science, in particular to a temperature-sensitive bisphenol A imprinted polymer microsphere and its application. Background technique [0002] Bisphenol A (BPA) chemical name is 2,2-bis(4-hydroxyphenyl)propane, is an important organic chemical raw material, widely used in plastic and resin products, antioxidants and reaction initiators. About 5% of BPA products are used in food packaging and flow into the water environment through industrial, agricultural and urban wastewater, etc., and become a major source of pollution. BPA has become a common endocrine disrupting estrogen in daily life. Studies have confirmed that long-term exposure to excessive levels of BPA can interfere with the balance of the human endocrine system and cause a series of health problems, and its low-dose harmfulness has also attracted attention. Therefore, there is an urgent need for efficient...

Claims

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Application Information

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IPC IPC(8): C08F257/02C08F220/56C08F226/06C08F222/38C08F222/14C08F2/44C08J9/28G01N33/00G01N1/40
Inventor 李金花董瑞晨陈令新
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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