Cyclodextrin cross-linking polymeric microsphere capable of absorbing bilirubin and its preparation and application

A cross-linked polymer and cyclodextrin technology, applied in other chemical processes, chemical instruments and methods, etc., can solve the problems of cumbersome preparation process of adsorption materials, poor selectivity and blood compatibility, and unsatisfactory removal effect, etc., to achieve Good clinical application potential, simple preparation process, high removal efficiency and selectivity
CN1541761AInactive Publication Date: 2004-11-03DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Publication Date
2004-11-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to the removal of bilirubin from blood, and is especially cyclodextrin crossed polymer microsphere for adsorbing bilirubin and its preparation and application. The microsphere is prepared with diisocyanate as crosslinking agent and through condensation with cyclodextrin monomer. The polymer microsphere of the present invention has low cost and results in simplified experiment process, and the efficient removal of bilirubin with the polymer microsphere shows that the said material has excellent clinical application latent.
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Description

technical field

[0001] The invention relates to the removal of bilirubin in blood, in particular to cyclodextrin cross-linked polymer microspheres for absorbing bilirubin and its preparation and application. Background technique

[0002] The removal of bilirubin in the blood has always been one of the focuses of the medical community. At present, scientists have adopted many methods to remove excess bilirubin in the blood, such as phototherapy, hemodialysis, and hemoperfusion. (hemoperfusion) or a combination of multiple technologies. With the development of synthetic chemistry and polymer chemistry, hemoperfusion has gradually become a powerful means to remove bilirubin; now the materials used in this area mainly include activated carbon, resin, and polymers with dyes as affinity groups; Activated carbon is used as the adsorption material, the particles are easy to scatter and cause blood clogging, and the albumin-collodion activated carbon microcapsules are made into albu...

Claims

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