Medical adhesive used for adhering skin and viscus hemostasis, and its prepn. method

A technology of skin bonding and adhesive, which is applied in the field of medical glue, can solve the problems of being low, can only be attached to the surface of internal organs for hemostasis, cannot perform anastomotic repair and coverage, and has low polymerization heat, so as to improve the hemostatic effect. , easy application, and the effect of reducing the heat of polymerization

Inactive Publication Date: 2005-11-09
石平安
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the fact that it is generally considered that high-carbon alkyl ester monomers are more suitable for bonding wounds to replace sutures in medical and health care, α-butyl cyanoacrylate and α-octyl cyanoacrylate are now being studied, although these adhesives Low toxicity and low heat of polymerization, but both have low adhesive strength, can only adhere to the surface of internal organs for hemostasis, and cannot play anastomotic repair and covering functions, while the low-carbon chain ethyl α-cyanoacrylate, although adhesive It has the advantages of high bonding strength, but has the disadvantages of hard polymer, brittleness, and high polymerization heat.

Method used

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  • Medical adhesive used for adhering skin and viscus hemostasis, and its prepn. method
  • Medical adhesive used for adhering skin and viscus hemostasis, and its prepn. method
  • Medical adhesive used for adhering skin and viscus hemostasis, and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Monomer

[0070] Glue dispensing: In the 100,000-class cleanliness purification workshop, the constant temperature and relative humidity should not exceed 80%, the illumination value of the lighting should not be lower than 300Lx, and the uniformity of illumination should not be less than 0.7. The room must be sterilized by ultraviolet light, and then the above table Proportionally weigh 10g of α-ethyl cyanoacrylate, 20g of ethoxyethyl α-cyanoacrylate, 20g of n-butyl α-cyanoacrylate, and 50g of n-octyl α-cyanoacrylate. After stirring for 60 minutes in the three-neck flask of the agitator, sterilize, and then fill in 0.5mm / ampoules in a class 100 clean room, and then pass the quality inspection, and the biological performance test is in line with the National Medical Products Administration standard. Labeled, boxed and packaged for delivery.

Embodiment 2

[0072] Monomer

[0073] Concrete compounding method is the same as embodiment 1

Embodiment 3

[0075] Monomer

[0076] Concrete compounding method is the same as embodiment 1

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Abstract

A medical adhesive for adhering skin and hemostasis of viscera is prepared from at least two organic compounds chosen from alpha-ethyl cyanoacrylate, alpha-ethoxyethyl cyanoacrylate, alpha-butyl cyanoacrylate and alpha-octyl cyanoacrylate through proportional mixing.

Description

Technical field: [0001] The invention relates to a medical adhesive for bonding human tissues, in particular to a medical adhesive made of any two, three permutations and combinations or four complete mixtures of four existing chemical raw materials and a preparation method thereof. Background technique: [0002] Since the advent of the "Eastman910" adhesive in the United States in 1959, the instant adhesive mainly based on α-cyanoacrylate has made great progress, and its proportion in the entire adhesive industry has continued to increase, and its application range has become wider and wider. This kind of adhesive has the characteristics of wide bonding range, high strength and instant curing, and is widely used in industry. And this kind of adhesive also has a bonding effect on organisms such as skin, and is non-toxic, and some varieties have begun clinical application on the basis of animal experiments. [0003] Most α-cyanoacrylate monomers are colorless, transparent, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06
Inventor 石平安
Owner 石平安
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