75 results about "N-butyl-cyanoacrylate" patented technology

A medical adhesive for adhering skin and hemostasis of viscera is prepared from at least two organic compounds chosen from alpha-ethyl cyanoacrylate, alpha-ethoxyethyl cyanoacrylate, alpha-butyl cyanoacrylate and alpha-octyl cyanoacrylate through proportional mixing.

The role of nanoparticle composition as biodegradable carriers for variously therapeutical drugs is disclosed. Nanoparticles are synthesized by anion emulsion polymerization of two alkyl-cyanoacrylate monomers with adjusted content ratio. By modulating the compositions, particle size, hydrophobicity and degradation rate of the copolymers is controlled. Hence, to encapsulate wide range of therapeutical drugs, poly(alkyl cyanoacrylate) nanoparticles with feasible compositions are applied individually. The copolymer nanoparticles produced by n-butyl cyanoactylate (BCA) and 2-octyl cyanoacrylate (OCA), for example, were used therein. The nanoparticles composed of poly[(n-butyl cyanoacrylate)-co-(2-octyl cyanoacrylate)] and poly(2-octyl cyanoacrylate) might be adequate for therapeutical administration.

A spray-type staltic adhesive is prepared from the alpha-n-octyl cynoacrylate (1-50 wt.%) and the alpha-n-butyl cynoacrylate (1-80 wt.%) through proportioning, sequentially loading them in a container, stirring for 30-80 min, filtering by 0.45-micron medical film, and biological testing to be negative. Its advantages are high polymerizing speed, adhesion and diffusivity, less intradermal reaction, and high safety. It can be used in human body.

The invention discloses a medical adhesive, comprising the following substances in parts by weight: 65-80 parts of alpha-N-butylcyanoacrylate, 5-8 parts of hydroxypropyl methacrylate, 3-5 parts of sulfur dioxide, 1-2 parts of hydroquinone, 0.5-2 parts of polyurethane, 0.5-1.5 parts of agar, 0.8-1.2 parts of fibrin glue, 2-3 parts of water soluble phenol-formaldehyde resin, and 20-25 parts of deionized water. The medical adhesive has the beneficial effects that the medical adhesive provided by the invention is low in thrill, and excellent in bonding persistence; compared with the traditional common adhesive, the persistence of the medical adhesive can be up to 1.5-3 times; and animal experiments show that the toxic and side effects are small.

The invention discloses a preparation method of polybutylcyanoacrylate-encapsulated jasminum grandiflorum essence capsule, wherein the nano jasminum grandiflorum essence capsule is prepared by the following raw materials in parts by weight: 0.2-0.5 parts of jasminum grandiflorum essence, 1.0-2.3 parts of polyoxyethylene (20) sorbitan monolaurate, 0.4-1.0 part of butylcyanoacrylate monomer and 96-100 parts of deionized water. As tested by a dynamic laser particle sizer, the nano jasminum grandiflorum essence capsule prepared according to the method of the invention has the average particle diameter of 112nm, the particle size distribution coefficient of 0.104 and stable existence of system, and has the advantages of slow release of fragrance and long fragrance lasting time, etc.

Cyanoacrylate adhesive compositions comprise a mixture of two cyanoacrylate monomers, including 2-octyl cyanoacrylate and n-butyl cyanoacrylate. The monomers are stabilized and sterilized by irradiation, and do not substantially increase in viscosity after sterilization or after two years of shelf storage. These compositions have anti-microbial properties, and may be used to close wounds as well as secure catheters inserted into the body in place.

The invention belongs to the technical field of manufacturing of an animal specimen and discloses a manufacturing method for fish, bird, mammalia and skeleton specimen. The method mainly comprises the steps of manufacturing specimen precursor, filling prosthesis, solidifying and forming, and sealing externally; utilizing alpha-octyl 2-cyanoacrylate or / and alpha-n-butyl cyanoacrylate matching prosthesis to form the specimen precursor; and utilizing alpha-octyl 2-cyanoacrylate or / and alpha-n-butyl cyanoacrylate to solidify, form and externally seal the specimen precursor after being formed. According to the technical scheme provided by the invention, the difficulty in preparing the animal specimen is reduced, the manufacturing cost of the specimen is also reduced, and meanwhile, the quality and storage effect of the specimen are increased on the basis of ensuring the manufacturing health of the specimen. The technical scheme provided by the invention has commercial popularizing value and significance.

The invention discloses a deproteinated calf blood ingredient brain targeting nanosphere preparation method, specifically comprising: according to the parts by weight, dissolving 5-30 parts of stabilizing agent in distilled water, then dissolving 5-30 parts of pluronic F-68 in distilled water, mixing the two obtained solution, shaking well, adding 50-100 parts of deproteinated calf blood extractive injection, shaking well, after constant volume, adjusting the PH value to 1-4, slowly adding 5-30 parts of polybutylcyanoacrylate while stirring; stirring for 1-6h, adjusting PH value to 6-8, stirring for 1-6h to obtain the colloid solution of deproteinated calf blood ingredient nanosphere, filtering, freeze drying; dissolving the freezedrying powder of deproteinated calf blood ingredient nanosphere, adding 5-30 parts of tween 80 and stirring for 0.5-3h to obtain deproteinated calf blood ingredient brain targeting nanophere. The invention has the advantages of simple preparation method, low cost, easy storage, short time to reach the brain, rapid blood clearance rate and the like.

A preparation method of a polylactic acid modified medical operation incision adhesion agent is characterized in that the adhesion agent comprises the components by weight: 100-120 parts of n-butyl cyanoacrylate, 1-3 parts of hydroquinone, 1-2 parts of sulfur dioxide, 1-3 parts of polylactic acid, 1-3 parts of cis-butenedioic anhydride, and 0.5-1 part of acrylic ester. The materials are mixed uniformly to obtain the product. The adhesion agent has the advantages of easily obtained raw materials, low cost, green environmental protection, convenient use, and good effect.

The present invention relates to a nano preparation of antimycotic amphotericin B (AmB). Said invention is made up by using n-butyl poly cyanoacrylate as carrier material of AmB. The animal tests show that it can permeate through blood-brain barrier, the measured medicine concentration in brain tissue is higher than that of AmB liposome preparation in clinical application, said nano preparation of antimycotic amphotericin B (AmB) is superior to AmB liposome preparation in therapeutic effect.

The invention discloses a method for preparing nano rose essence capsules, which comprises the following steps of: a, mixing 0.3 to 0.8 weight percent of rose essence and 2.0 to 3.2 weight percent of polyoxyethylene (20) sorbitan monolaurate, stirring the mixture at the rotation speed of 1,100rpm, adding deionized water into the mixture and stirring to form a uniform emulsion; and b, dripping 0.6 to 1.6 weight percent of N-butyl cyanoacrylate into the emulsion, reacting for 2 to 4 hours, adjusting the pH value of the system with 1mol / L solution of sodium hydroxide to 7.0, and continuously reacting for 0.5 hour until the reaction is completed. The nano rose essence capsules prepared by the emulsion polymerization method of the invention have an average particle size of 91nm and a peak width of 16.8nm, have uniform particle size distribution and can be applied to goods for everyday consumption, such as textiles, cosmetics and detergents and the like.

The invention discloses a preparation method of a jasmine sambac essence capsule. The nanometer essence consists of the following components by weight part: 0.66 to 1.06 jasmine sambac essences, 0.54 to 2.4 NBCA, 2 to 3.2 surfactants (selected from polyoxyethylene (20) sorbitan mono-laurate, polyoxyethylene sorbitan palmitate and polyoxyethylene sorbitan monooleate), and 93.62 to 96.26 deionized water. The nanometer jasmine sambac essence emulsion prepared by the invention is milk white, blue light phenomenon is obvious, and the system is uniform and stable. Jasmine flowers have obvious perfume and graceful and delicate fragrance. Tested by dynamic laser light scattering, the nanometer jasmine sambac essence has uniform particle size distribution, the average particle size is 70.8nm and the particle size distribution coefficient is 0.210.

The invention discloses high-molecular plastic particles for a cable and a preparation method for the high-molecular plastic particles. The plastic particles comprise the following components in parts by weight: 25-35 parts of low density polyethylene, 6-13 parts of silane crosslinked polyethylene, 12-20 parts of chloroprene rubber, 4-7 parts of polyphthalamide, 3-9 parts of polyhydroxybenzoate, 1.5-4.5 parts of alpha-n-butyl cyanoacrylate, 2.5-5.5 parts of dibutyltin dilaurate, 2-5 parts of tributyl borate and 2-5 parts of dioctyl phthalate. The preparation method comprises the following steps of: (1) uniformly mixing the materials in a high speed mixer for later use; (2) then extruding the mixed materials which are uniformly mixed by a twin-screw extruder; and (3) granulating the materials which are extruded by the twin-screw extruder to prepare the high-molecular plastic particles for the cable. The prepared high-molecular plastic particles for the cable are suitable for a cable sheath material.

The invention provides a carbon nanofiber-chitosan-polyvinyl alcohol medical composite film and a preparation method thereof. The film comprises the following ingredients: 25-35 parts of carbon nanofibers, 12-18 parts of chitosan, 15-20 parts of polyvinyl alcohol, 5-9 parts of butyl alpha-cyanoacrylate, 3-7 parts of sodium dodecyl sulfate, 2-5 parts of low-density polyethylene, 3-5 parts of plasticizers, 2-3 parts of cross-linking agents and 1-2 parts of antimicrobial agents. The preparation method comprises the steps that: (1) the ingredients are weighed in parts by weight; (2) the ingredients are put in a reaction kettle and subjected to heating reaction in a nitrogen atmosphere for 2-3h to form a preformed product; and (3) the preformed product is dissolved with dichloromethane, placed on the surface of a polyfluortetraethylene plate, dried, subjected to film uncovering, and placed in a dryer to be stored, and the medical composite film is obtained. The medical composite film prepared by the method is good in tensile property, simple in production process, safe and nontoxic, and has great application prospects in the field of medicines.

The invention discloses a medical adhesive, comprising the following substances in parts by weight: 65-80 parts of alpha-N-butylcyanoacrylate, 5-8 parts of hydroxypropyl methacrylate, 3-5 parts of sulfur dioxide, 1-2 parts of hydroquinone, 0.5-2 parts of polyurethane, 0.5-1.5 parts of agar, 0.8-1.2 parts of fibrin glue, 2-3 parts of water soluble phenol-formaldehyde resin, and 20-25 parts of deionized water. The medical adhesive has the beneficial effects that the medical adhesive provided by the invention is low in thrill, and excellent in bonding persistence; compared with the traditional common adhesive, the persistence of the medical adhesive can be up to 1.5-3 times; and animal experiments show that the toxic and side effects are small.

The invention belongs to the technical field of biomedical materials, particularly relates to a medical adhesive material capable of rapidly stopping bleeding, and further discloses a preparation method of the medical adhesive material. According to the medical adhesive material disclosed by the invention, alpha-n-butyl cyanoacrylate and alpha-n-octyl cyanoacrylate are used as a mixed medical adhesive matrix, and a hemostatic material namely carboxymethyl chitosan is swelled and modified in a manner that CO2 supercritical fluid carries selected ionic liquid, so that the bleeding stopping performance of the carboxymethyl chitosan is effectively improved, the bleeding stopping performance of the whole medical adhesive material is greatly improved, and rapid bleeding stopping is achieved.

The invention discloses an anti-bacterial and acid-alkali-resistant medical material and a preparation method thereof. The medical material is prepared from main ingredients including pharmaceutical grade polyvinyl alcohol, polypropylene resin, poly-3-hydroxybutyrate and polyethylene glycol fatty acid ester mixed with pentaerythritol oleate, octenyl succinic acid modified starch, citrate, N-butylcyanoacrylate, sulfanilamide, sodium citrate, polyactic acid fibers, aluminium silicate ceramic fibers, magnesium carbonate, gaseous-phase white carbon black, malic acid, a dispersing agent and a stabilizer by mixing, stirring, high-temperature sintering, grinding, high-pressure calcination, acid leaching, ultrasonic dispersion, screw extrusion, injection molding treatment and the like. The anti-bacterial and acid-alkali-resistant medical material has an excellent anti-bacterial property and acid and alkali resistance, can meet requirements of the industry and has better application prospect.

The invention discloses a preparing method of taxanes substance preparation with nanostructure. Taxanes substance is dissolved in organic solvent and then dispersed in alpha-PBCA, and taxanes substance is highly-dispersed aqueous emulsion under the action of other auxiliary agents to form taxanes substance preparation with nanostructure. The taxanes substance preparation with nanostructure has stable performance and particle size distribution of 50-500nm, is round without adhesion, has the slow release function, can biologically degrade and has no toxic and side effect. The invention has simple technology, environment-friendly preparing process and easy industrialization.

The invention discloses a medical adhesive with healing promoting and repairing functions. The medical adhesive is characterized by comprising the components, by weight, 20-25 parts of a-butylcyanoacrylate, 25-35 parts of a-isoctyl cyanoacrylate, 2-6 parts of styrene class thermoplastic elastomer microspheres, 25-37 parts of effective healing promoting and repairing components, 2-4 parts of sodiumalginate, 3-6 parts of sodium hyaluronate, 8-10 parts of allantoin, 1 part of hydrolyzed wheat protein, 1 part of stabilizer, 150-220 pats of compound fruit oil components and 200 parts of aquae sterilisata. The medical adhesive specially selects a variety of biological extracts with regenerative functions and adds three components of healing promoting and repairing components to promote healingand improve the repairing effect, has high bonding strength and good biocompatibility, and meets the clinical application requirements for medical adhesive.

The invention discloses a biomedical material special for human soft tissue adhesion. Alpha-butylcyanoacrylate, vinylpyrrolidone, hydroxypropyl methacrylate and isopropyl acrylate serve as the main components, citrate, aloe nano powder, benzil dimethyl ketal, N,N-dimethyl aniline, trilaurylamine, calcium carbonate, aluminum oxide, wollastonite powder, alumina-silicate ceramic fiber, degreased pupa powder, squalane, folium ginkgo extracts, L-cysteine and retarder are added, ball-milling, ultrasonic dispersing, mixing and stirring, drying, irradiation sterilizing and other processes are adopted, and therefore the adhesion strength, adhesion speed, adhesion durability and other aspects of the prepared biomedical material special for human soft tissue adhesion are remarkably improved, the industry requirements can be met, and the material has good application prospects.

The present invention discloses an antibiotic medicine which contains amoxicillin nano-particles and clavulanate potassium and is made from 0.2 percent to 0.4 percent of amoxicillin, 0.02 percent to 0.25 percent of the clavulanate potassium, 0.5 percent to 2 percent of carrier, 0.5 percent to 2 percent of stabilizing agent, 0.5 percent to 2 percent of surfactant and 93 percent to 98.5 percent of distilled water according to the following method that: carrier monomers and the surfactant are dissolved in the distilled water completely; the amoxicillin is added; pH value is adjusted to be 2 to 3; butyl cyanoacrylate is added while being stirred by magnetic force and is stirred continuously for 5 to 12 hours, the pH value is adjusted to be 6 to 7, flaxen amoxicillin poly butyl cyanoacrylate nano-particle colloid solution is obtained; the clavulanate potassium is added by the proportion of the amoxicillin and the clavulanate potassium of 2 ®U 1 to 10 ®U 1 to obtain the antibiotic medicine which not only has simple preparation method but also has the advantages of wide spectrum, high efficiency, being targeted, slow-released, safe, etc.

An adhesive for the wound of the pearl-culturing clam is proportionally prepared from alpha-butyl cyanoacrylate, alpha-isobutyl cyanoacrylate, hydroxymethyl cellulose, phenyldiphenol, and toluenesulfonic acid. Its advantages are short setting time, high water-proofing nature, and low dead rate of clam.

The invention discloses a biological material for a medical catheter. The biological material is prepared from the following raw materials in parts by weight: 15-20 parts of n-butyl cyanoacrylate, 5-10 parts of divinyl benzene, 1-5 parts of polyvinyl alcohol, 11-15 parts of polyurethane, 7-11 parts of polyethylene glycol terephthalate, 6-14 parts of collagen, 3-8 parts of calcium lignosulphonate, 2-6 parts of hydroquinone, 5-9 parts of citrate, 2-6 parts of ethylenediamine, 1-4 parts of gelatin, 2-4 parts of magnesium carbonate, 1-3 parts of silicon dioxide, 4-9 parts of sorbitol, 3-8 parts of an antioxidant, 2-5 parts of a disinfectant and 3-9 parts of a dispersing agent. The biological material for a medical catheter has stable performance and good durability, and is applicable to various biological environments and various medical catheters. Furthermore, the invention further discloses a method for preparing the biological material for a medical catheter.

The invention provides a hydrophilic polyurethane wound dressing for skin and a preparation method thereof. The dressing comprises the following components: polyurethane, n-butyl α-cyanoacrylate, hyaluronic acid, carboxymethyl cellulose, silk fibroin, Sodium alginate, succinochitosan, mannose, diclofenac diethylammonium salt. Preparation method: Weigh each component by weight; melt polyurethane, n-butyl α-cyanoacrylate, hyaluronic acid and carboxymethyl cellulose in a reaction kettle, add sodium alginate after complete melting, and keep warm ; Under the condition of constant stirring, slowly add the rest of the raw materials into the reaction kettle, and after being completely mixed, cool down and defoam; spread the mixture evenly on the base cloth, cool down, and cover the peeling layer on the coated colloid layer , that is. Compared with the prior art, it has good moisturizing performance, long-lasting moisturizing time, no irritation to skin, simple preparation method, low equipment requirements, and is suitable for large-scale popularization and application.

The invention discloses an epigallocatechin-gallate nano slow-release preparation and a preparation method thereof. The epigallocatechin-gallate nano slow-release preparation is prepared from an encapsulated medicine (epigallocatechin gallate) and an encapsulating material (polybutylcyanoacrylate). The preparation method of the epigallocatechin-gallate nano slow-release preparation provided by theinvention has the beneficial effects that no water and acetone system are used, the problem of residue of acetone solvents can not be caused, regulation of pH and intervention of other processes arenot needed, the process is simple, the cost is low, and the requirements of reaction conditions are low; the preparation method not only can bring economic benefit and is environmentally friendly, butalso has large social benefit and high application prospect.

The invention discloses a preparation method of magnetic doxorubicin polybutylcyanoacrylate nanoparticles, which relates to the preparation of osteosarcoma targeted therapeutic nanodrugs. The magnetic doxorubicin polybutylcyanoacrylate nanoparticles are mainly prepared by Fe3O4 water-based magnetic fluid, Dextran-70, Tween80, doxorubicin hydrochloride, Alpha-polybutylcyanoacrylate and so on. The ADM-PBCA-MNPS prepared by the invention is a novel targeted drug delivery system-magnetic targeted drug delivery system, which has the advantages of simple preparation method, lower production cost, good targeted effect, easy implementation of targeted therapy and so on, thus showing great application prospect in the field of the targeted therapy of tumors.

Cyanoacrylate adhesive compositions comprise a mixture of two cyanoacrylate monomers, including 2-octyl cyanoacrylate and n-butyl cyanoacrylate. The monomers are stabilized and sterilized by irradiation, and do not substantially increase in viscosity after sterilization or after two years of shelf storage. These compositions have anti-microbial properties, and may be used to close wounds as well as secure catheters inserted into the body in place.

Cyanoacrylate adhesive compositions comprise a mixture of two cyanoacrylate monomers, including 2-octyl cyanoacrylate and n-butyl cyanoacrylate. The monomers are stabilized and sterilized by irradiation, and do not substantially increase in viscosity after sterilization or after two years of shelf storage. These compositions have anti-microbial properties, and may be used to close wounds as well as secure catheters inserted into the body in place.

The invention provides an epigallocatechin gallate (EGCG) nanowire preparation as well as a preparation method and application thereof. The EGCG nanowire preparation is prepared from polybutyl cyanoacrylate nanowires and EGCG loaded on the polybutyl cyanoacrylate nanowires. The polybutyl cyanoacrylate nanowires are occasionally found to have an antibacterial effect, so that the application field of the polybutyl cyanoacrylate nanowires can be expanded, and a new bacteriostatic material is provided. The sterilizing rate of the EGCG nanowire preparation is proved to be higher than the sum of thesterilizing rates of the polybutyl cyanoacrylate nanowires and the EGCG.

The invention discloses an environment-friendly low-whitening instant adhesive. The instant adhesive is composed of the following materials: cage silsesquioxane / acrylate copolymer-modified ethyl alpha-cyanoacrylate, hydrophilic modified n-octyl alpha-cyanoacrylate, n-butyl alpha-cyanoacrylate and additives at a mass ratio of (1-10):(1-10):(80-95):(0.5-5). Through the instant adhesive, the technical problems of poor heat resistance, poor aging resistance, large irritating odor and easy whitening phenomena of a traditional instant adhesive are solved, and the use effect of the instant adhesive is improved through modification treatment and reasonable compounding of the different components.