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Carbon nanofiber-chitosan-polyvinyl alcohol medical composite film and preparation method thereof

A technology of nano-carbon fiber and polyvinyl alcohol, which is applied in the field of biomaterials, can solve the problems of high manufacturing cost of composite materials, and achieve the effects of simple production process, good tensile performance and great application prospects

Inactive Publication Date: 2015-06-24
SUZHOU VIVOTIDE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been reports on the preparation of new membrane materials by blending polyvinyl alcohol with sodium alginate and chitosan. Although the mechanical strength of the composite material has been effectively improved, the preparation cost of the composite material is relatively high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A nano-carbon fiber-chitosan-polyvinyl alcohol medical composite film, in parts by weight, comprising the following components: 25 parts of nano-carbon fiber, 12 parts of chitosan, 15 parts of polyvinyl alcohol, and n-butyl α-cyanoacrylate 5 parts of esters, 3 parts of sodium dodecylsulfate, 2 parts of low-density polyethylene, 3 parts of tributyl citrate, 2 parts of carbodiimide and 1 part of ethyl vanillin.

[0021] The preparation method includes the following steps:

[0022] (1) Weigh each component by weight;

[0023] (2) Put each component into the reaction kettle, heat it to 60°C in a nitrogen atmosphere, stir continuously at a speed of 400r / min, react for 2h, and obtain the pre-finished product;

[0024] (3) Dissolve the pre-finished product obtained in step (2) with N,N-dimethylformamide, place it on the surface of a polytetrafluoroethylene board, dry at a constant temperature at 45±2°C, uncover the film, and place it in a desiccator It is preserved in medium to obtai...

Embodiment 2

[0026] A nano carbon fiber-chitosan-polyvinyl alcohol medical composite film, in parts by weight, comprising the following components: 28 parts of nano carbon fiber, 14 parts of chitosan, 17 parts of polyvinyl alcohol, and n-butyl α-cyanoacrylate 6 parts of esters, 4 parts of sodium dodecylsulfate, 3 parts of low-density polyethylene, 3 parts of acetyl tributyl citrate, 2 parts of carbodiimide and 2 parts of vanillin.

[0027] The preparation method includes the following steps:

[0028] (1) Weigh each component by weight;

[0029] (2) Put the components into the reaction kettle, heat to 65°C in a nitrogen atmosphere, stir continuously at a speed of 350r / min, react for 2h to obtain the pre-finished product;

[0030] (3) Dissolve the pre-finished product obtained in step (2) with N,N-dimethylformamide, place it on the surface of a polytetrafluoroethylene board, dry at a constant temperature at 45±2℃, uncover the film, and place it in a desiccator It is preserved in medium to obtain th...

Embodiment 3

[0032] A nano-carbon fiber-chitosan-polyvinyl alcohol medical composite film, in parts by weight, comprising the following components: 30 parts of nano-carbon fiber, 15 parts of chitosan, 18 parts of polyvinyl alcohol, and n-butyl α-cyanoacrylate 6 parts of esters, 5 parts of sodium dodecylsulfate, 4 parts of low-density polyethylene, 3 parts of tributyl citrate, 3 parts of glutaraldehyde and 2 parts of vanillin.

[0033] The preparation method includes the following steps:

[0034] (1) Weigh each component by weight;

[0035] (2) Put each component into the reaction kettle, heat it to 70°C in a nitrogen atmosphere, stir continuously at a speed of 300r / min, react for 2.5h, and obtain a pre-finished product;

[0036] (3) Dissolve the pre-finished product obtained in step (2) with N,N-dimethylformamide, place it on the surface of a polytetrafluoroethylene board, dry at a constant temperature at 45±2°C, uncover the film, and place it in a desiccator It is preserved in medium to obtain t...

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Abstract

The invention provides a carbon nanofiber-chitosan-polyvinyl alcohol medical composite film and a preparation method thereof. The film comprises the following ingredients: 25-35 parts of carbon nanofibers, 12-18 parts of chitosan, 15-20 parts of polyvinyl alcohol, 5-9 parts of butyl alpha-cyanoacrylate, 3-7 parts of sodium dodecyl sulfate, 2-5 parts of low-density polyethylene, 3-5 parts of plasticizers, 2-3 parts of cross-linking agents and 1-2 parts of antimicrobial agents. The preparation method comprises the steps that: (1) the ingredients are weighed in parts by weight; (2) the ingredients are put in a reaction kettle and subjected to heating reaction in a nitrogen atmosphere for 2-3h to form a preformed product; and (3) the preformed product is dissolved with dichloromethane, placed on the surface of a polyfluortetraethylene plate, dried, subjected to film uncovering, and placed in a dryer to be stored, and the medical composite film is obtained. The medical composite film prepared by the method is good in tensile property, simple in production process, safe and nontoxic, and has great application prospects in the field of medicines.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a nano-carbon fiber-chitosan-polyvinyl alcohol medical composite film and a preparation method thereof. Background technique [0002] Polyvinyl alcohol is a non-toxic, non-irritating, hydrophilic synthetic polymer with excellent biocompatibility and biodegradability, and can form a smooth and tear-resistant film. It is a good biomedical Material. It has been reported that polyvinyl alcohol, sodium alginate, and chitosan are blended to prepare new membrane materials. Although the mechanical strength of the composite material is effectively improved, the preparation cost of the composite material is relatively high. Therefore, the blending modification of polyvinyl alcohol still needs further research. [0003] Nanomaterials have the advantages of large specific surface area, high surface activity, and high bonding strength with polymers. Therefore, filling nanomaterials int...

Claims

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Application Information

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IPC IPC(8): C08L29/04C08L5/08C08L23/06C08K13/04C08K7/06C08K5/315C08K5/42C08K5/11C08K5/13C08J5/18
Inventor 王彦军刘大学邱东成
Owner SUZHOU VIVOTIDE BIOTECH
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