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Epigallocatechin gallate (EGCG) nanowire preparation as well as preparation method and application thereof

A technology for epigallocatechin and gallate, which is applied to epigallocatechin gallate nanowire preparations and the fields of preparation and application thereof, can solve the problems such as failure to achieve bacteriostatic or bactericidal effects, and achieve obvious effects , the effect of low toxicity and low energy consumption

Active Publication Date: 2018-09-21
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the antibacterial effect does not increase but decreases, and the effective antibacterial or bactericidal effect cannot be achieved.

Method used

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  • Epigallocatechin gallate (EGCG) nanowire preparation as well as preparation method and application thereof
  • Epigallocatechin gallate (EGCG) nanowire preparation as well as preparation method and application thereof
  • Epigallocatechin gallate (EGCG) nanowire preparation as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Preparation of Epigallocatechin Gallate Nanowire Preparation

[0044] The preparation method comprises the following steps:

[0045] (1) Raw material configuration

[0046] The configuration of organic phase raw materials: add 0.04 g of EGCG to 100 ml of anhydrous acetone, ultrasonically for 5 minutes, fully dissolve to obtain solution 1, and set aside; mix 0.2 ml of n-butyl α-cyanoacrylate and 4.0 ml of ethyl acetate thoroughly Immediately after adding solution 1, mix well to obtain the organic phase raw material, set aside;

[0047]The configuration of the water phase raw material: mix 0.8 g of sodium lauryl sulfate, 1.0 g of dextran-70 and 100 ml of ultrapure water, then adjust the pH value to 3.0 with 1mol / L hydrochloric acid to obtain the water phase raw material, and set aside;

[0048] (2) Polymerization reaction

[0049] After the organic phase raw material was magnetically stirred at room temperature for 20 minutes, it was slowly added dropwise to the aqueou...

Embodiment 2

[0056] Preparation of Epigallocatechin Gallate Nanowire Preparation

[0057] The preparation method comprises the following steps:

[0058] (1) Raw material configuration

[0059] The configuration of organic phase raw materials: add 0.06 g of EGCG to 100 ml of anhydrous acetone, ultrasonically for 5 minutes, fully dissolve to obtain solution 1, set aside; fully mix 0.3 ml of n-butyl α-cyanoacrylate and 6.0 ml of ethyl acetate Immediately after adding solution 1, mix well to obtain the organic phase raw material, set aside;

[0060] The configuration of the water phase raw material: mix 0.6 g of sodium lauryl sulfate, 0.8 g of dextran-70 and 100 ml of ultrapure water, then adjust the pH value to 2.5 with 1 mol / L hydrochloric acid to obtain the water phase raw material, and set aside;

[0061] (2) Polymerization reaction

[0062] After the organic phase raw material was magnetically stirred at room temperature for 23 minutes, it was slowly added dropwise to the aqueous phase...

Embodiment 3

[0067] Preparation of Epigallocatechin Gallate Nanowire Preparation

[0068] The preparation method comprises the following steps:

[0069] (1) Raw material configuration

[0070] The configuration of organic phase raw materials: add 0.08 grams of EGCG to 100 milliliters of anhydrous acetone, sonicate for 5 minutes, fully dissolve to obtain solution 1, and set aside; fully mix 0.4 milliliters of n-butyl α-cyanoacrylate and 8.0 milliliters of ethyl acetate Immediately after adding solution 1, mix well to obtain the organic phase raw material, set aside;

[0071] The configuration of the water phase raw material: mix 1.0 g of sodium lauryl sulfate, 1.2 g of dextran-70 and 100 ml of ultrapure water, then adjust the pH value to 2.0 with 1 mol / L hydrochloric acid to obtain the water phase raw material, and set aside;

[0072] (2) Polymerization reaction

[0073] After the organic phase raw material was magnetically stirred at room temperature for 27 minutes, it was slowly added ...

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Abstract

The invention provides an epigallocatechin gallate (EGCG) nanowire preparation as well as a preparation method and application thereof. The EGCG nanowire preparation is prepared from polybutyl cyanoacrylate nanowires and EGCG loaded on the polybutyl cyanoacrylate nanowires. The polybutyl cyanoacrylate nanowires are occasionally found to have an antibacterial effect, so that the application field of the polybutyl cyanoacrylate nanowires can be expanded, and a new bacteriostatic material is provided. The sterilizing rate of the EGCG nanowire preparation is proved to be higher than the sum of thesterilizing rates of the polybutyl cyanoacrylate nanowires and the EGCG.

Description

technical field [0001] The invention relates to an epigallocatechin gallate nanowire preparation and a preparation method and application thereof. Background technique [0002] The Chinese invention patent application with the application number 201610276036.1 discloses a method for preparing poly(n-butyl cyanoacrylate) nanowires. The poly(n-butyl cyanoacrylate) nanowires prepared by this method are non-toxic and harmless, and have good biocompatibility. It has good biodegradability and can be used as a biological material, but this application does not study other applications of polycyanoacrylate n-butyl nanowires. [0003] Epigallocatechin-3-O-gallate ((-)-Epigallocatechin-3-O-gallate, EGCG) is a catechin monomer substance isolated from green tea, which has the highest content and the strongest biological activity among tea polyphenols. It mainly has various physiological effects such as anti-oxidation, scavenging free radicals, anti-tumor, lowering blood fat, improving ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/32A61K31/353A61P31/04
CPCA61K9/0092A61K31/353A61K47/32A61P31/04
Inventor 鲍官虎姚京京胡启明
Owner ANHUI AGRICULTURAL UNIVERSITY
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