Epigallocatechin-gallate nano slow-release preparation and preparation method thereof

A technology of epigallocatechin and gallate, which is applied in the field of epigallocatechin gallate nano-sustained-release preparations and its preparation, can solve the problems of expensive carrier materials, preparations that cannot be taken orally, and complicated preparation processes, and achieve Wide range of biomedical applications, low requirements for reaction conditions, and good biocompatibility

Active Publication Date: 2018-10-16
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, many researchers have also prepared nano-preparations of epigallocatechin gallate, such as chitosan-coated epigallocatechin gallate nanoparticles, β-globulin-coated epigallocatechin gallate Ester nanoparticles, cadmium sulfide-coated epigallocatechin gallate nanoparticles, the nanoparticle epigallocatechin gallate nanoparticles formed by these wrapping materials have a relatively large particle size, particle size adhesion, instability, And the prepared preparations cannot be taken orally, and the packaging materials are toxic (such as metal materials) or the carrier materials are expensive, and their preparation process is complicated, the preparation conditions are harsh, and the preparation process may produce toxic and harmful substances.
These severely limit their application

Method used

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  • Epigallocatechin-gallate nano slow-release preparation and preparation method thereof
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  • Epigallocatechin-gallate nano slow-release preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Preparation of Epigallocatechin Gallate Nanoscale Sustained Release Preparation

[0046] The preparation method comprises the following steps:

[0047] (1) Raw material preparation

[0048] Preparation of oil phase raw materials: uniformly disperse 17 microliters of n-butyl α-cyanoacrylate in 1 milliliter of ethyl acetate;

[0049] Preparation of emulsified phase raw materials: uniformly disperse 25 mg of poloxamer-68 and 50 mg of dextran-70 in 5 ml of ultrapure water, dissolve with ultrasound at room temperature, stir and mix evenly;

[0050] (2) Polymerization reaction

[0051] Accurately weigh 2 mg of epigallocatechin gallate and add it to the oil phase raw material, shake and mix evenly to obtain the mixture I, and then drop the mixture I into the emulsified phase raw material within 6 minutes for interfacial polymerization reaction , the reaction is carried out under magnetic stirring at a rotating speed of 850 rpm, and the total time of the reaction is 3 hours;...

Embodiment 2

[0058] Preparation of Epigallocatechin Gallate Nanoscale Sustained Release Preparation

[0059] The preparation method comprises the following steps:

[0060] (1) Raw material preparation

[0061] Preparation of oil phase raw materials: uniformly disperse 10 microliters of n-butyl α-cyanoacrylate in 1 milliliter of ethyl acetate;

[0062] Preparation of emulsified phase raw materials: uniformly disperse 25 mg of poloxamer-68 and 50 mg of dextran-70 in 5 ml of ultrapure water, dissolve with ultrasound at room temperature, stir and mix evenly;

[0063] (2) Polymerization reaction

[0064] Accurately weigh 1 mg of epigallocatechin gallate and add it to the oil phase raw material, shake and mix evenly to obtain the mixture I, and then drop the mixture I into the emulsified phase raw material within 4 minutes for interfacial polymerization reaction , the reaction is carried out under magnetic stirring at a rotating speed of 800 revolutions per minute, and the total time of the r...

Embodiment 3

[0070] Preparation of Epigallocatechin Gallate Nanoscale Sustained Release Preparation

[0071] The preparation method comprises the following steps:

[0072] (1) Raw material preparation

[0073] Preparation of oil phase raw materials: uniformly disperse 15 microliters of n-butyl α-cyanoacrylate in 1 milliliter of ethyl acetate;

[0074] Preparation of emulsified phase raw materials: uniformly disperse 20 mg of poloxamer-68 and 45 mg of dextran-70 in 5 ml of ultrapure water, dissolve with ultrasound at room temperature, stir and mix evenly;

[0075] (2) Polymerization reaction

[0076] Accurately weigh 2 mg of epigallocatechin gallate and add it to the oil phase raw material, shake and mix evenly to obtain the mixture I, and then drop the mixture I into the emulsified phase raw material within 8 minutes for interfacial polymerization reaction , the reaction is carried out under magnetic stirring at a rotating speed of 900 rpm, and the total time of the reaction is 2.5 hour...

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Abstract

The invention discloses an epigallocatechin-gallate nano slow-release preparation and a preparation method thereof. The epigallocatechin-gallate nano slow-release preparation is prepared from an encapsulated medicine (epigallocatechin gallate) and an encapsulating material (polybutylcyanoacrylate). The preparation method of the epigallocatechin-gallate nano slow-release preparation provided by theinvention has the beneficial effects that no water and acetone system are used, the problem of residue of acetone solvents can not be caused, regulation of pH and intervention of other processes arenot needed, the process is simple, the cost is low, and the requirements of reaction conditions are low; the preparation method not only can bring economic benefit and is environmentally friendly, butalso has large social benefit and high application prospect.

Description

technical field [0001] The invention relates to a nanometer slow-release preparation of epigallocatechin gallate and a preparation method thereof. Background technique [0002] Epigallocatechin-3-O-gallate ((-)-Epigallocatechin-3-O-gallate, EGCG) is a catechin monomer substance isolated from green tea, and its content accounts for about 50% of tea polyphenols. Studies have shown that epigallocatechin gallate has strong biological activity and pharmacological effects. In recent years, as the research on catechins has become more and more extensive, the research on epigallocatechin gallate is also deepening, because it has anti-aging, anti-cancer, anti-inflammatory, anti-oxidation and anti-free radical scavenging Pharmacological effects, such as biomedicine, health care, food industry, daily chemical industry and other fields have shown a very important role, the application prospects will be very impressive. [0003] However, the properties of epigallocatechin gallate are v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/32A61K31/353A61P35/00
CPCA61K9/5138A61K31/353A61P35/00
Inventor 鲍官虎姚京京胡启明
Owner ANHUI AGRICULTURAL UNIVERSITY
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